A5101855570- Genetics and Neurodevelopmental Disorders
- Endoplasmic Reticulum Stress and Disease
- Light effects on plants
- Autophagy in Disease and Therapy
- Circadian rhythm and melatonin
- Mycorrhizal Fungi and Plant Interactions
- Phytochemistry and Bioactive Compounds
- Photoreceptor and optogenetics research
- Natural product bioactivities and synthesis
- Garlic and Onion Studies
- Ubiquitin and proteasome pathways
- Plant chemical constituents analysis
- Phytochemical Studies and Bioactivities
- Signaling Pathways in Disease
- Lipid metabolism and biosynthesis
- Plant Toxicity and Pharmacological Properties
- Plant Pathogenic Bacteria Studies
- Neurobiology and Insect Physiology Research
- Genomics and Phylogenetic Studies
- Insect-Plant Interactions and Control
- Sesquiterpenes and Asteraceae Studies
- Plant Virus Research Studies
Seoul National University
2023-2025
Korea Forest Service
2020-2023
Northwestern University
2020
Konkuk University
2016-2017
Although defects in intracellular calcium homeostasis are known to play a role the pathogenesis of Parkinson's disease (PD), underlying molecular mechanisms remain unclear. Here, we show that loss PTEN-induced kinase 1 (PINK1) and Parkin leads dysregulation inositol 1,4,5-trisphosphate receptor (IP
Diabetic sensory neuropathy (DSN) is one of the most common complications type 2 diabetes (T2D), however molecular mechanistic association between T2D and DSN remains elusive. Here we identify ubiquitin C-terminal hydrolase L1 (UCHL1), a deubiquitinase highly expressed in neurons, as key molecule underlying DSN. Genetic ablation UCHL1 leads to neuronal insulin resistance T2D-related symptoms Drosophila. Furthermore, loss induces DSN-like phenotypes, including numbness external noxious...
Abstract Wolfram syndrome (WS) is marked by juvenile-onset diabetes mellitus, optic atrophy, insipidus, and sensorineural hearing loss. The causative genes, WFS1 CISD2 , correspond to WS types 1 2, respectively. Here, we establish their mutual indispensability for inositol 1,4,5-triphosphate receptor (IP 3 R) activity, demonstrating ability restore reduced IP R activity in WFS1- or CISD2-deficient mammalian cells. Additionally, our Drosophila models lacking dWFS1 dCISD exhibit diabetes-like...
2,6,6-Trimethylbicyclo[3.1.1]hept-2-ene (α-Pinene) is an organic compound of the terpene class found in essential oil many plants. In this study, inhibitory effect α-pinene on tumor invasion highly metastatic MDA-MB-231 human breast cancer cells was evaluated. α-Pinene inhibited necrosis factor (TNF)-α-induced invasiveness as revealed by three-dimensional spheroid assay. Further analysis showed that reduced TNFα-induced matrix metalloproteinase-9 gene promoter activation and mRNA expression...
The juice of Ageratum houstonianum is used in folk medicine as an external wound healing aid for skin injuries. However, the active component A. and its mode action has not been investigated. This study was conducted to investigate effect ethanolnolic extract (AHE) on expression aquaporin-3 (AQP3), integral membrane protein water glycerol transport keratinocytes, identify structure bioactive compound. Here, we show that AHE increased AQP3 gene at transcriptional level through p38 MAPK...
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