A5085652795- Circadian rhythm and melatonin
- Light effects on plants
- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Plant Molecular Biology Research
- Photoreceptor and optogenetics research
- Dietary Effects on Health
- Sleep and Wakefulness Research
- Calcium signaling and nucleotide metabolism
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Coenzyme Q10 studies and effects
- Sleep and related disorders
- Apelin-related biomedical research
- Diet and metabolism studies
- Nuclear Receptors and Signaling
- Mitochondrial Function and Pathology
- Tryptophan and brain disorders
University of California, San Francisco
2024
Northwestern University
2013-2023
Circadian clocks are self-sustained cellular oscillators that synchronize oxidative and reductive cycles in anticipation of the solar cycle. We found clock transcription feedback loop produces nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, adenosine triphosphate production, mitochondrial respiration through modulation protein acetylation to metabolic pathways with 24-hour fasting feeding control activity NAD(+)-dependent deacetylase sirtuin 3 (SIRT3) generated rhythms enzymes...
Aging drives the occurrence of numerous diseases, including cardiovascular disease (CVD). Recent studies indicate that blood from young mice reduces age-associated pathologies. However, "anti-aging" factors in juvenile circulation remain poorly identified. Here, we characterize role apelinergic axis mammalian aging and identify apelin as an anti-aging factor. The expression (apln) its receptor (aplnr) exhibits age-dependent decline multiple organs. Reduced apln signaling perturbs organismal...
In mammals, circadian rhythms are entrained to the light cycle and drive daily oscillations in levels of NAD
Exogenous glucocorticoids interact with the circadian clock, but little attention is paid to timing of intake. We recently found that intermittent once-weekly prednisone improved nutrient oxidation in dystrophic muscle. Here, we investigated whether dosage time affected effects on muscle bioenergetics. In mice treated prednisone, drug dosing light-phase promoted nicotinamide adenine dinucleotide (NAD + ) levels and mitochondrial function wild-type muscle, while this response was lost...
SUMMARY The circadian clock synchronizes metabolic and behavioral cycles with the rotation of Earth by integrating environmental cues, such as light. Nutrient content also regulates clock, though how why this signal affects remains incompletely understood. Here, we elucidate a role for nutrient in regulating alignment to seasonal photoperiods. High fat diet (HFD) promoted entrainment summer light cycle inhibited winter phosphorylating PER2 on serine 662. PER2-S662 phospho-mimetic mutant mice...
Aging | doi:10.18632/aging.203766. Vera Gorbunova, Marcus Buschbeck, Xiaolu A. Cambronne, Karthikeyani Chellappa, Daniela Corda, Juan Du, Marc Freichel, Jonathan Gigas, Alexander E. Green, Feng Gu, Iva Guberovic, Aravinthkumar Jayabalan, Imrankhan Khansahib, Sarmistha Mukherjee, Andrei Seluanov, Matthew Simon, Lars J. Sverkeli, Nora Kory, Daniel C. Levine, Ivan Matic, Andrey Nikiforov, Johannes G.M. Rack, Shin-Ichiro Imai, David Sinclair, Debra Toiber, Yongjuan Zhao, Raul Mostoslavsky, Lee...
The molecular clock machinery regulates several homeostatic rhythms, including glucose metabolism. We previously demonstrated that Roux-en-Y gastric bypass (RYGB) has a weight-independent effect on homeostasis and transiently reduces food intake. In this study we investigate the effects of RYGB diurnal eating behavior as well clock's requirement for metabolic bariatric procedure in obese mice. find reversed high-fat diet-induced disruption pattern during early postsurgery phase reduction....
Abstract In plants, Cryptochromes are photoreceptors that negatively regulate CRL4 Cop1 (Cul4-RING ubiquitin ligase and its substrate receptor Cop1). mammals, core components of the circadian clock repressors glucocorticoid (GR). Moreover, mammalian lost their ability to interact with Cop1, suggesting they unable inhibit . Contrary this assumption, we found also negative regulators through mechanism repress GR transcriptional network both in cultured cells mouse liver. Mechanistically,...
In plants, Cryptochromes are photoreceptors that negatively regulate CRL4Cop1 (Cul4-RING ubiquitin ligase and its substrate receptor Cop1). mammals, core components of the circadian clock repressors glucocorticoid (GR). Moreover, mammalian lost their ability to interact with Cop1, suggesting they unable inhibit CRL4Cop1. Contrary this assumption, we found also negative regulators through mechanism repress GR transcriptional network both in cultured cells mouse liver. Mechanistically,...