A5101665883- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- NF-κB Signaling Pathways
- Autophagy in Disease and Therapy
- Gene expression and cancer classification
- Single-cell and spatial transcriptomics
- Cytokine Signaling Pathways and Interactions
- Cancer, Hypoxia, and Metabolism
- Kruppel-like factors research
- Immune Response and Inflammation
- Calcium signaling and nucleotide metabolism
- Mesenchymal stem cell research
- Inflammasome and immune disorders
- Angiogenesis and VEGF in Cancer
- Histone Deacetylase Inhibitors Research
- Mechanisms of cancer metastasis
- Insect Utilization and Effects
- Nail Diseases and Treatments
- Bone Tumor Diagnosis and Treatments
- Click Chemistry and Applications
- Nanocluster Synthesis and Applications
- Circadian rhythm and melatonin
- Adipose Tissue and Metabolism
- Bone and Joint Diseases
- Body Composition Measurement Techniques
Catholic University of Korea
2020-2024
Korea University Medical Center
2023
Seoul National University
2010-2022
Konkuk University
2018-2019
Korea University
2018
Sogang University
2015
University of Pittsburgh
2015
Abstract Hypoxia-inducible factor-1α (HIF-1α) mediates hypoxic responses and regulates gene expression involved in angiogenesis, invasion metabolism. Among the various HIF-1α posttranslational modifications, methylation its physiological role have not yet been elucidated. Here we show that is methylated by SET7/9 methyltransferase, lysine-specific demethylase 1 reverses methylation. The functional consequence of modulation stability primarily nucleus, independent proline hydroxylation,...
Inspired by self-repair mechanism of PSII in plants, we report a self-healing system which spontaneously repairs molecular catalyst and photosensitizer during photocatalytic H2 evolution. A bipyridine-embedded UiO-type metal–organic framework (MOF), namely Ptn_Ir_BUiO, incorporated H2-evolving photosensitizer, was synthesized subject to evolution reaction (HER). Impressively, HER with Pt0.1_Ir_BUiO showed very stable photocatalysis without significant decrease its activity colloidal...
Retinoic acid-related orphan receptor α (RORα) functions as a transcription factor for various biological processes, including circadian rhythm, cancer, and metabolism. Here, we generate intestinal epithelial cell (IEC)-specific RORα-deficient (RORα ΔIEC ) mice find that RORα is crucial maintaining homeostasis by attenuating nuclear κB (NF-κB) transcriptional activity. exhibit excessive inflammation highly activated inflammatory responses in the dextran sulfate sodium (DSS) mouse colitis...
Abstract Autophagy is a catabolic process through which cytoplasmic components are degraded and recycled in response to various stresses including starvation. Recently, transcriptional epigenetic regulations of autophagy have emerged as essential mechanisms for maintaining homeostasis. Here, we identify that coactivator-associated arginine methyltransferase 1 (CARM1) methylates Pontin chromatin-remodeling factor under glucose starvation, methylated binds Forkhead Box O 3a (FOXO3a)....
Significance An aberrant covalent histone modification which drives dysregulation of transcriptional program is related to human diseases such as cancer. Thus, identifying signaling pathways modulating transcription factors and epigenetic enzymes are coming into view attractive therapeutic targets. In this study, we provide evidence that KDM3A tyrosine-phosphorylated by JAK2, acts a coactivator for STAT3, thereby exerting increased cancer cell growth motility. We propose JAK2-dependent...
During exercise, skeletal muscle is exposed to a low oxygen condition, hypoxia. Under hypoxia, the transcription factor hypoxia-inducible factor-1α (HIF-1α) stabilized and induces expressions of its target genes regulating glycolytic metabolism. Here, using muscle-specific gene ablation mouse model, we show that Brg1/Brm-associated 155 (Baf155), core subunit switch/sucrose non-fermentable (SWI/SNF) complex, essential for HIF-1α signaling in muscle. Muscle-specific Baf155 increases oxidative...
Despite recent progress in medical and endovascular therapy, the prognosis for patients with critical limb ischemia (CLI) remains poor. In response, various stem cells growth factors have been assessed use therapeutic neovascularization salvage CLI patients. However, clinical outcomes of cell-based angiogenesis not provided promised benefits, reinforcing need novel angiogenic strategies to cure untreatable CLI. present study, we investigated genetically engineered mesenchymal (MSCs) derived...
Autophagy, a catabolic process to remove unnecessary or dysfunctional organelles, is triggered by various signals including nutrient starvation. Depending on the types of deficiency, diverse sensing mechanisms and signaling pathways orchestrate for transcriptional epigenetic regulation autophagy. However, our knowledge about type-specific during autophagy limited. To understand type-dependent autophagy, we performed single cell RNA sequencing (scRNAseq) in mouse embryonic fibroblasts (MEFs)...
Abstract Despite the utility of multiparameter flow cytometry for a wide variety biological applications, comparing single parameter histograms fluorescence intensity remains mainstay cytometric analysis. Even comparisons requiring gating strategies often end with as final readout. When overlap, analysis relies on comparison mean or median intensities, determination percent positive based an arbitrary cutoff. Earlier attempts to address this problem utilized either simple channel‐by‐channel...
본 연구는 갈색거저리 및 동애등에 유충 오일의 간 손상 장내누수증의 억제 효능을 확인하고자 하였다. 갈색거저리와 오일을 처리한 후에 알코올을 먹인 그룹에서 조직의 중성지방 함량을 감소시킨다는 것을 확인할 수 있었으며, H&E Oil-red O 염색 결과 lipid droplet이 감소함을 확인하였다. 지방대사에 관련된 유전자인 PPARγ, C/EBPα, SREBP-1c, FAS 유전자 발현이 유의적으로 감소하는 또한, 급성 알코올에 의해 증가한 장내독소 염증 인자인 TNF-α의 오일 투여로 억제되는 효과를 가지고 있는 또한 상기 유충오일들은 알코올 섭취에 활성산소종에 의한 산화적 손상을 예방하는 보여주었다. 원인이 되는 장벽의 확인한 EtOH 그룹의 TJ/AJ 단백질 발현 정도는 정상군보다 감소한 알 오일은 장벽 억제하였다. CYP2E1과 iNOS 소장 역시, 유충오일 투여에 억제됨을 오일이 나타나는 장내 산화 스트레스 억제하는 가짐을 제시하고 있다. 곤충의 기능성 임상 연구...