A5100327077- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Peroxisome Proliferator-Activated Receptors
- Drug Transport and Resistance Mechanisms
- Pancreatitis Pathology and Treatment
- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Esophageal and GI Pathology
- Natural product bioactivities and synthesis
- Colorectal Cancer Screening and Detection
- Inflammatory mediators and NSAID effects
- Pediatric Hepatobiliary Diseases and Treatments
- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Stroke Rehabilitation and Recovery
- Liver physiology and pathology
Hallym University Dongtan Sacred Heart Hospital
2014-2024
University of California, San Diego
2015-2024
Hallym University
2013-2024
Catholic University of Korea
2024
Konkuk University
2020-2024
Sun Yat-sen University
2024
Sir Run Run Shaw Hospital
2024
Zhejiang University
2024
Third Affiliated Hospital of Sun Yat-sen University
2024
Stony Brook University Hospital
2023
Statin has been known not only as their cholesterol-lowering action but also on pleiotropic effects including anti-inflammatory and anti-oxidant well anti-cancer effect. Nrf2 (NF-E2-related factor 2) is a transcription to activate cellular antioxidant response oxidative stress. There are little whether statins affect activation of signaling pathway in colon cancer cells. We investigated simvastatin stimulates the expression nuclear translocation which signal involved enzymes. effect two...
In June 2015, a local public health laboratory was notified that students had developed gastroenteritis symptoms after attending camp. An outbreak investigation conducted to determine the extent and cause of outbreak.A retrospective cohort study correlations between illness specific exposures at school All attendees were interviewed with standard questionnaire addressed clinical symptoms, food consumption, environmental exposures. Clinical specimens cultured using microbiological methods for...
The aim of this study was to investigate the effects exercise (EX) and Korean red ginseng (KRG) on inflammation mechanism in aging model rats with diet-induced atherosclerosis.Forty-eight male Sprague-Dawley were divided into 6 groups: Young control (Y-C), Aging (A-C), A-C HFD (AHF), AHF EX (AHF-EX), AHF-EX KRG (AHF-EX+RG), (AHF-RG). induced by D-gal (100mg/kg) atherosclerosis (60% fat) for 9 weeks. experimental performed swimming (60 min/day, 5 days/week) supplied orally (dose 200 mg/kg) 8...
Maternal psychological health during pregnancy has been associated with offspring psychopathology. However, it is uncertain whether these associations are mediated by the postpartum depression and related child-rearing factors. Therefore, we examined between prenatal postnatal factors internalizing externalizing behavioral problems in childhood, focusing on maternal school-aged children Korea. The current study included 1,003 (580 boys, 423 girls, mean age 9.05 ± 0.70 years, range 8–11...
This study investigated the mechanism of processed tomato vinegar beverage (TVB)-mediated anti-obesity and anti-insulin resistance effects in high-fat diet (HF)-induced obese mice. Oral administration TVB (14 mL kg−1 body weight) to HF-fed mice for 6 weeks effectively reduced visceral fat weight significantly lowered plasma free fatty acid, triglyceride hepatic levels. increased fecal excretion, both phosphorylated AMP-activated protein kinase (AMPK) acetyl-CoA carboxylase (ACC) peroxisome...
Gallstone pathogenesis is linked to mucin hypersecretion and bacterial infection. Several genes have been identified in gallbladder epithelial cells (GBECs). We investigated MUC expression cholesterol-associated disease evaluated the relationship between infection.The present study involved 20 patients with cholesterol stones cholecystitis, five cholesterolosis, six polyps, two cancer, controls. Canine GBECs treated lipopolysaccharide were also studied. MUC3, MUC5AC, MUC5B, MUC6 antibodies...
Background/Aims: Metformin has been found to have antineoplastic activity in some cancer cells.This study was performed determine whether metformin inhibits the proliferation of bile duct cells by inducing apoptosis and its effects on expression gene-related proteins involved growth.Methods: Human extrahepatic (SNU-245 SNU-1196) were cultured.3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays effect cell proliferation.Apoptosis measured a death detection enzyme-linked...
Objective . Barley sprout ( Hordeum vulgare L.) contains 4.97% fat, 52.6% polysaccharide, and 34.1% protein along with a variety of vitamins, minerals, polyphenolic compounds. Hexacosanol is one such compound from the barley leaf that might improve cholesterol metabolism by decreasing synthesis. Method Therefore, this study was conducted to investigate effects extract on serum lipid in healthy volunteers<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mo...
Insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1R) signaling plays an important role in tumor progression patients with certain gastrointestinal tract cancers. In addition to lowering cholesterol serum, statins have pleiotropic effects, including anti-oxidative, anti‑inflammatory or anti‑neoplastic effects. Therefore, the present study investigated whether could induce apoptosis of colon cancer cells regulate expression IGF‑1R its associated pathways study. It was demonstrated...
Scopoletin is a bioactive component in many edible plants and fruits. This study investigated the effects of scopoletin on hepatic steatosis inflammation high‐fat diet fed type 1 diabetic mice by comparison with metformin. (0.01%, w/w) or metformin (0.5%, was provided to streptozotocin‐induced for 11 weeks. Both lowered blood glucose HbA 1c , serum ALT, TNF‐α IL‐6 levels, intolerance, lipid accumulation compared control group. down‐regulated gene expression triglyceride ( Pparg Plpp2 Dgat2 )...
This study compared the muscle activities of erector spinae (ES), external oblique (EO), and rectus abdominis (RA) on three different surfaces. The purpose this was to determine which surface induces highest activity during plank exercises. information from can be used recommend exercises athletes patients with weak core muscles.
<i>Background/Aims:</i> No reliable nationwide clinical data about chronic pancreatitis (CP) was available in Korea. The etiology and features of CP were investigated using a multicenter study. <i>Methods:</i> 814 cases enrolled retrospectively over the past 4 years at 13 hospitals. following obtained from all patients: etiology, symptoms, complications, surgery. <i>Result:</i> Alcohol (64.3%) major cause idiopathic (20.8%) second most common form. Mean...
Specialized proresolving mediators (SPMs), such as resolvins and maresins, resolve inflammation protect against infection at trace amounts generated by neutrophils macrophages in humans. Thus, SPMs have been leading compounds treatment of infection. These synthesized using chemical methods, which disadvantages use toxic reagents, many (20–30) step reactions, expensive processes. Here, we first discovered a human SPM-producing microorganism found 15-lipoxygenase (15-LOX) from the that...
Gall-bladder epithelial cells (GBEC) are exposed to high concentrations of cholesterol in bile. Whereas absorption by GBEC is established, the fate this absorbed not known. The aim study was determine whether ABCA1 (ATP-binding cassette transporter A1) mediates efflux GBEC. Polarized canine were cultured on porous membrane filters allowing separate access apical (AP) and basolateral (BL) compartments. After AP loading with model bile [14C]cholesterol, measured. Cholesterol together...