A5057599101- Immune Cell Function and Interaction
- Natural product bioactivities and synthesis
- Immunotherapy and Immune Responses
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Fungal Biology and Applications
- Food Quality and Safety Studies
- Bone Metabolism and Diseases
- Lichen and fungal ecology
- Metabolomics and Mass Spectrometry Studies
- Transgenic Plants and Applications
- Medicinal plant effects and applications
- Effects of Radiation Exposure
- Phytochemicals and Antioxidant Activities
- T-cell and B-cell Immunology
- Bone health and osteoporosis research
- Phytochemistry and biological activity of medicinal plants
- Antimicrobial Peptides and Activities
- Cholinesterase and Neurodegenerative Diseases
- Pharmacological Effects of Natural Compounds
- Synthesis and biological activity
- Garlic and Onion Studies
- melanin and skin pigmentation
- Phytochemistry and Bioactive Compounds
- Toxin Mechanisms and Immunotoxins
Sunchon National University
2015-2024
In-Q-Tel
2019
Kyungpook National University
1996-1998
National Institute of Infectious Diseases
1997
National Institute of Health Sciences
1994-1997
The University of Tokyo
1997
Lichens are symbiotic organisms which produce distinct secondary metabolic products. In the present study, we tested cytotoxic activity of 17 lichen species against several human cancer cells and further investigated molecular mechanisms underlying their anti-cancer activity. We found that among lichens species, F. cucullata exhibited most potent cytotoxicity in cells. High performance liquid chromatography analysis revealed acetone extract contains usnic acid, salazinic Squamatic...
Although astaxanthin has a variety of biological activities such as anti-oxidant effects, inhibitory effects on skin deterioration and anti-inflammatory its effect asthma not been studied. In this paper, the airway inflammation in mouse model ovalbumin (OVA)-induced was investigated. We evaluated number total cells, Th1/2 mediated inflammatory cytokines bronchoalveolar lavage fluid (BALF) hyperresponsiveness well histological structure. The level IgE, IgG1, IgG2a, OVA-specific IgG2a were...
Osteoporosis is characterized by a reduction of the bone mineral density (BMD) and microarchitectural deterioration bone, which lead to fragility susceptibility fracture. Astaxanthin (AST) has variety biological activities, such as protective effect against asthma or neuroinflammation, antioxidant effect, decrease osteoclast number in right mandibles periodontitis model. Although treatment with AST known have an on inflammation, no studies exposure loss been performed. Thus, present study,...
Abstract Background Although cisplatin is one of the most effective chemotherapeutic agents, alone does not achieve a satisfactory therapeutic outcome. Also accumulation shows toxicity to normal tissues. In this study, we examined possibility HemoHIM both enhance anticancer effect with and reduce side effects in melanoma-bearing mice. Methods was prepared by adding ethanol-insoluble fraction total water extract mixture 3 edible herbs, Angelica Radix, Cnidium Rhizoma Paeonia Radix. Anticancer...
We evaluated the effect of bu-zhong-yi-qi-tang, a prescription traditional Oriental medicine, and its major ingredients on protection intestine hematopoietic organs against radiation damage in this study. The jejunal crypt survival, endogenous spleen colony formation, apoptosis cells were investigated mice irradiated with high low doses gamma-rays. bu-zhong-yi-qi-tang administration before irradiation protected crypts (p < 0.0001), increased formation 0.05) reduced frequency...
We studied the effects of high mobility group box chromosomal protein 1 (HMGB1) and toll-like receptor (TLR4) in diisonoyl phthalate (DINP)-induced asthma. Mice with DINP-induced asthma were treated a TLR4-signaling inhibitor or anti-HMGB1 antibody, various markers measured 24 h later. DINP increased airway hyperresponsiveness, numbers cells BALF, inflammatory (leukocytes, lymphocytes, monocytes, eosinophils, neutrophils, basophils) blood, mucus production, pulmonary fibrosis, Th2 type...
Abstract Among 276 herbal extracts, a methanol extract of Castanopsis cuspidata var. sieboldii stems was selected as an experimental source for novel acetylcholinesterase (AChE) inhibitors. Five compounds were isolated from the by activity-guided screening, and their inhibitory activities against butyrylcholinesterase (BChE), monoamine oxidases (MAOs), β-site amyloid precursor protein cleaving enzyme 1 (BACE-1) also evaluated. Of these compounds, 4′- O -(α- l -rhamnopyranosyl)-3,3′,4-tri-...
Mesenchymal stem cells (MSCs) are pluripotent adult cells. It has been shown that MSCs secrete neurotrophic factors involving nerve growth factor (NGF) and brain-derived (BDNF). Also, these can upregulate tyrosine hydroxylase (TH) gene expression in PC12 neural Here, we investigated the effect of co-culturing rat E13.5 ventral mesencephalic (VMCs) with from bone marrow on TH dopamine (DA) content. The study consisted 3 groups: MSC, VMC a combined MSC+VMC group. All groups were cultured...
Abstract BACKGROUND Salicornia herbacea L . is a halophyte that grows in salt marshes and contains significant amounts of salts minerals. Because it known as folk medication to treat diseases, various processed products such powder, globular type laver extract have been developed. However, difficult process drink because its high salinity. In the present study, glasswort vinegar ( GV ) containing organic acids minerals was developed via two‐step fermentation with unpolished rice substrates...
Angelica gigas Nakai, Cnidium officinale Makino, and Paeonia japonica Miyabe) was developed to protect immune, hematopoietic, self-renewal tissues against radiation. This study determined whether or not HemoHIM could alter hyperglycemia the immune response in diabetic mice. Both nondiabetic mice were orally administered (100 mg/kg) once a day for 4 weeks. Diabetes induced by single injection of streptozotocin (STZ, 200 mg/kg, i.p.). In mice, effectively improved glucose tolerance compared...
Lichens, composite organisms resulting from the symbiotic association between fungi and algae, produce a variety of secondary metabolites that exhibit pharmacological activities. This study aimed to investigate anti-inflammatory activities metabolite atraric acid produced by Heterodermia hypoleuca. The results confirmed could regulate induced pro-inflammatory cytokine, nitric oxide, prostaglandin E2, oxide synthase cyclooxygenase-2 enzyme expression in lipopolysaccharide (LPS)-stimulated...
Physconia hokkaidensis methanol extract (PHE) was studied to identify anticancer effects and reveal its mechanism of action by an analysis cytotoxicity, cell cycles, apoptosis biomarkers. PHE showed strong cytotoxicity in various cancer cells, including HL-60, HeLa, A549, Hep G2, AGS, MDA-MB-231, MCF-7. Of these lines, the growth MDA-MB-231 concentration-dependently suppressed PHE, but MCF-7 not affected. triple-negative breast (TNBC) do express estrogen receptor (ER), progesterone (PR),...
2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside (TSG), an active polyphenolic component of Polygonum multiflorum, exhibits many pharmacological activities including antioxidant, anti-inflammation, and anti-aging effects. A previous study demonstrated that TSG protected MC3T3-E1 cells from hydrogen peroxide (H2O2) induced cell damage the inhibition osteoblastic differentiation. However, no studies have investigated prevention ovariectomy-induced bone loss in mice. Therefore, we effects on...
In addition to their use as colorants, anthraquinone derivatives have numerous medical applications, for example, antibacterial and antiinflammatory agents. We confirmed that physcion (an derivative) induces TNF-alpha production by macrophages increased the expressions of surface molecules (CD40, CD80, CD86) major histocompatibility complex (MHC) II. Based on these results, we hypothesized might induce maturation dendritic cells (DCs) antigen-presenting (APCs), decided conduct in vitro...