Liver transplantation (LT) is a promising treatment option for patients with hepatocellular carcinoma (HCC) comorbid cirrhosis. However, HCC portal vein tumor thrombosis (PVTT) remains an absolute contraindication LT. This study aimed to analyze the outcomes of LT in plus and further evaluate impact PVTT on long-term patients. Among 501 who underwent between January 2000 March 2023, 29 (5.8%) had were analyzed. Of these thrombosis, 12 (41.4%) preoperatively diagnosed after receiving...

Abstract Background Neutrophil‐lymphocyte ratio ( NLR ) represents a pro‐tumor inflammatory environment and host immunity. The aim of this study was to examine the effect subsequent for hepatocellular carcinoma (HCC) after liver resection. Methods A total 672 patients had resection HCC were included in study. at diagnosis recurrence collected. 2.5 used as cut‐off value calculate its prognostic effect. Results According value, with >2.5 larger tumor size, higher histology grade, rates...

Immune checkpoint inhibitors (ICI) have been applied to treat advanced stage hepatocellular carcinoma (HCC) and obtain promising effects. However, tumor response treatment was unpredictable. A predicting biomarker of objective or disease-control is an unmet need for patient selection. In this study, 45 HCC patients who failed sorafenib received nivolumab, 3 mg/kg bi-weekly, were included. Tumor responses nivolumab assessed by the modified evaluation criteria in solid tumors (mRECIST)...

The three-dimensional (3D) cell culture technique has been applied comprehensively as a variable platform for medical research, biochemical signal pathway analysis, and evaluation of anti-tumor treatment response due to an excellent recapitulation tumor microenvironment (TME) in the vitro cultured cancer cells.Pancreatic (PaC) is one toughest malignancies with complex TME refractory response.To study PaC, there eager need develop 3D model decompose cellular components their cross...

Donor safety is crucial for living donor liver transplantation (LDLT), and sufficient regeneration significantly affects outcomes of donors. This study aimed to investigate clinical factors associated with in The retrospectively reviewed 380 donors who underwent donation at Chang Gung Memorial Hospital Linkou. characteristics medical parameters were analyzed compared according graft type. There 355 (93.4%) right hemi-liver donations 25 (6.6%) left donations. Left had a higher body mass index...

Microvascular invasion (MVI) is a significant risk factor for the recurrence of hepatocellular carcinoma, but it histological feature that needs to be confirmed after hepatectomy or liver transplantation. The preoperative prediction MVI can optimize treatment plan HCC, an easy and widely applicable model still lacking. aim our study was predict using objective factors. We retrospectively collected 1153 patients who underwent resection found associated with significantly poor disease-free...

Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with 5-year survival rate of 6% following diagnosis, and novel therapeutic modalities are needed. Protease-activated receptor 1 (PAR1) abundantly overexpressed by both tumor cells multiple stroma cell subsets in the microenvironment (TME), thereby offering suitable immunotherapy target.A chimeric antigen (CAR) strategy was applied to target PAR1 using human anti-PAR1 scFv antibody fused transmembrane region two...

Background: Patients with hepatocellular carcinoma (HCC) tend to be referred for liver transplantation (LT) at an early stage of cirrhosis, lower pre-LT Model End-Stage Liver Disease (MELD) scores. We investigated the impact high MELD scores on post-LT outcomes in patients HCC and validated prognostic significance neutrophil-to-lymphocyte ratio (NLR). Method: This retrospective single-center cohort study enrolled 230 who underwent LDLT from 2004−2019 our institute. defined a score as ≥20....

Acute liver failure is life-threatening and has to be treated by transplantation urgently. When deceased donors or ABO-compatible living are not available, ABO-incompatible (ABO-I) donor (LDLT) becomes the only choice. How prepare ABO-I LDLT urgently an unsolved issue. A quick preparation regimen was designed, which consisted of bortezomib (3.5 mg) injection deplete plasma cells exchange achieve isoagglutinin titer ≤ 1: 64 just prior followed rituximab (375 mg/m2 ) on post-operative day 1...

Liver transplant recipients are immunocompromised and have low immunogenicity to produce antibodies in anti-COVID-19 vaccination. Whether immunosuppressant adjustment could facilitate antibody production mRNA vaccination is undetermined. Our patients were informed temporarily suspend mycophenolate mofetil (MMF) or everolimus (EVR) for 2 weeks during both the 1st 2nd doses of Moderna mRNA-1273 vaccine. A total 183 receiving two vaccine enrolled grouped into tacrolimus monotherapy (MT, n =...

BACKGROUND:Taiwan has a high prevalence of hepatitis B virus (HBV) infection. HBV-related end-stage liver disease is the leading cause transplantation (LT). Tenofovir alafenamide (TAF) recently approved agent for treatment chronic HBV infection that improves renal profiles compared with tenofovir disoproxil fumarate (TDF) in phase III trials. This study aimed to assess outcomes TAF LT recipients. MATERIAL AND METHODS:This retrospective analyzed 17 recipients who underwent TDF and TAF....

In many Asian hepatocellular carcinoma (HCC) guidelines, resection is an option for multiple HCCs. It difficult to compare small but tumors vs. fewer large in terms of the traditional tumor burden definition. We aimed evaluate role liver HCCs and determine factors associated with survival benefits. reviewed 160 patients who underwent between July 2003 December 2018. The risk recurrence were assessed using Cox proportional hazards modeling, was analyzed Kaplan–Meier method. all patients, 133...

BACKGROUND Liver transplantation (LT) is the preferred treatment for patients with cirrhosis who have hepatopulmonary syndrome (HPS). However, effect of HPS on LT remains controversial. We assessed correlation between severity and survival compared incidence postoperative complications without undergoing LT. MATERIAL AND METHODS retrospectively reviewed recipients received living-donor in our institute January 2016 July 2019. Patients (HPS group) (non-HPS were included study. defined as a...

Portal vein thrombus (PVT) is a challenge in liver transplantation. How PVT develops cirrhotic patients who already have coagulopathy unclear. This study aimed to investigate possible contributing factors patients. A total of 349 waited transplantation were included this and 48 them had PVT. For all the patients, mean age was 53.5 ± 9.0 year old, 75.9% male. There 233 (66.8%) either hepatitis B or C. The Model End-Stage Liver Disease (MELD) score 16.4 7.5. Eighteen with 145 301 without...

Abstract Background and Objectives Precise prognostic prediction for an individual hepatocellular carcinoma (HCC) patient before after liver resection is important. We aimed to establish simple models predict disease‐free survival (DFS) these patients. Methods Six hundred ninety‐eight HCC patients with resections were reviewed. Preoperative (model 1) postoperative 2) nomogram‐based scoring systems constructed by multivariate analyses, DFS was estimated. Results Among 698 patients, 490...

Tyrosine kinase inhibitors (TKIs) remain the primary therapeutic option for patients with advanced-stage hepatocellular carcinoma (HCC). However, selection of a suitable TKI is an issue in real-world clinical practice. Thus, this study aimed to identify most likely benefit from lenvatinib treatment.A retrospective review 143 unresectable HCC treated between January 2020 and December 2021 was performed. Outcomes related treatment were measured, parameters affecting prognosis analyzed.Overall,...

Background: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS–HIPEC) is a therapeutic approach used to achieve curative treatment in intra-abdominal malignancy peritoneal carcinomatosis (PC). However, it complicated procedure high post-operative complication rates. Thus, we analyzed our preliminary data establish whether multidisciplinary teamwork (MDT) implementation beneficial for CRS–HIPEC outcomes. Method: A series of 132 consecutive patients synchronous or...

Liver transplantation can be performed with deceased or living donor allografts. Deceased liver grafts are donated from brain- circulation-death patients, and they have usually suffered a certain degree of damage. Post-transplant graft function patient survival closely related to allograft recovery. How define the damage is unclear. A total 47 donors, 23 24 living, were enrolled in this study. All donors had severe brain damage, six them experienced cardio-pulmonary-cerebral resuscitation...

Dexmedetomidine, an α2-adrenergic receptor agonist, is used as anti-anxiety medication. It exerts a cholinergic effect, thereby reducing the release of tumor necrosis factor alpha (TNF-α). We hypothesized that use dexmedetomidine sedative agent in transplantation would also protect allografts. examined our patients who underwent living donor liver transplantation. Subsequently, we generated series mouse models to investigate effect on sedation-based tolerance post A total 49 recipients were...

Background . A combination of antihepatitis B immunoglobulin and antiviral agents is the most common regimen for prophylaxis hepatitis recurrence after liver transplantation. However, still happens. The significance less mentioned. Materials Forty-eight 313 transplant recipients having were included in this study. patients divided into group A, transplanted B-related failure, B, cirrhosis HCC. clinical manifestations recorded. Results Among 48 with recurrence, 23 25 B. age was <mml:math...

Abstract Background Therapeutic effect and immunosuppressor cell alteration in adding transcatheter arterial chemoembolization (TACE) to sorafenib for advanced stage hepatocellular carcinoma (HCC) remain unclear. Aims To examine the therapeutic TACE sorafenib. Methods Forty‐four HCC patients were divided into group A (n = 17) treated by (400‐600 mg/day) alone B 27) TACE. The frequency of regulatory T‐cells myeloid‐derived suppressor cells (MDSC), patients' outcomes examined. Advanced...

Cytomegalovirus (CMV) infection has a significant negative impact on liver transplant (LT) recipients. We aimed to evaluate the efficacy of real-time DNA quantitative polymerase chain reaction (qPCR) in early detection CMV and predicting post-transplant outcomes.This was retrospective study that enrolled total 49 adult LT recipients between December 2016 October 2019. Serial qPCR were tested weekly. used operating characteristic curve analysis quantify replication numbers decide optimal...

Combined cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) to treat peritoneal surface malignancy (PSM) has gained a positive result compared with palliative alone in several cancer types. However, its postoperative care could be challenging. We aimed develop predicting model on early mortality.We retrospectively reviewed 132 PSM patients who had received CRS-HIPEC. The optimal cut-off value of the neutrophil-to-lymphocyte ratio (NLR) was determined as 4.4 by...