A5101895331- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune cells in cancer
- Renal Transplantation Outcomes and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Reproductive System and Pregnancy
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Cancer Mechanisms and Therapy
- Macrophage Migration Inhibitory Factor
- RNA Interference and Gene Delivery
- Amino Acid Enzymes and Metabolism
- Colorectal Cancer Treatments and Studies
- Neural Networks and Reservoir Computing
- COVID-19 Clinical Research Studies
- Transplantation: Methods and Outcomes
- Hepatitis Viruses Studies and Epidemiology
- Immune Cell Function and Interaction
- Photonic and Optical Devices
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
Chang Gung Memorial Hospital
2014-2024
Chang Gung University
2014-2024
Linkou Chang Gung Memorial Hospital
2014-2024
National Institute of Information and Communications Technology
2024
Weatherford College
2021
Memorial Hospital of South Bend
2020
Johns Hopkins Hospital
2017
University of Baltimore
2016
Johns Hopkins University
2016
Sidney Kimmel Comprehensive Cancer Center
2016
PURPOSE Durable partial response (PR) and durable stable disease (SD) are often seen in patients with hepatocellular carcinoma (HCC) receiving atezolizumab plus bevacizumab (atezo-bev). This study investigates the outcome of these histopathology residual tumors. PATIENTS AND METHODS The IMbrave150 study's atezo-bev group was analyzed. PR or SD per RECIST v1.1 lasting more than 6 months defined as durable. For histologic analysis, a comparable real-world from Japan Taiwan who had undergone...
The objective of this study was to evaluate the results adult ABO-incompatible living donor liver transplantation (LDLT). LDLT is an aggressive treatment that crosses blood-typing barrier for saving lives from diseases. Although graft and patient survival have been improved recently by various treatments, require further evaluation. Two regimens were designed based on isoagglutinin IgG IgM titers time course immunological reactions at institute. When ≤64, directly performed rituximab (375...
Donor safety is crucial for living donor liver transplantation (LDLT), and sufficient regeneration significantly affects outcomes of donors. This study aimed to investigate clinical factors associated with in The retrospectively reviewed 380 donors who underwent donation at Chang Gung Memorial Hospital Linkou. characteristics medical parameters were analyzed compared according graft type. There 355 (93.4%) right hemi-liver donations 25 (6.6%) left donations. Left had a higher body mass index...
Abstract Liver resection remains the popular treatment for hepatocellular carcinoma (HCC). The aim of this study was to explore alteration immune cells in HCC patients with liver resections. Nineteen were included and their peripheral blood samples taken before after resections immune-cell analysis. clinical characteristics showed that median diameter resected tumors 7.5 cm a range from 1.4 16.5 cm. analysis percentage CD4 + T-cells not altered by resection, but CD8 T-cell decreased 31.7 ±...
Background: Organ demand for liver transplantation (LT) is constantly increasing. Split (SPLT) an ideal option increasing the number of available grafts and ameliorating organ shortage to a certain degree. However, SPLT two adult recipients still not broadly applied. Methods: We retrospectively analyzed outcomes at single center. All donor, recipient, factors were thoroughly investigated clarify affecting patient after LT. Results: One hundred consecutive SPLTs performed during study period....
Acute liver failure is life-threatening and has to be treated by transplantation urgently. When deceased donors or ABO-compatible living are not available, ABO-incompatible (ABO-I) donor (LDLT) becomes the only choice. How prepare ABO-I LDLT urgently an unsolved issue. A quick preparation regimen was designed, which consisted of bortezomib (3.5 mg) injection deplete plasma cells exchange achieve isoagglutinin titer ≤ 1: 64 just prior followed rituximab (375 mg/m2 ) on post-operative day 1...
Liver transplant recipients are immunocompromised and have low immunogenicity to produce antibodies in anti-COVID-19 vaccination. Whether immunosuppressant adjustment could facilitate antibody production mRNA vaccination is undetermined. Our patients were informed temporarily suspend mycophenolate mofetil (MMF) or everolimus (EVR) for 2 weeks during both the 1st 2nd doses of Moderna mRNA-1273 vaccine. A total 183 receiving two vaccine enrolled grouped into tacrolimus monotherapy (MT, n =...
BACKGROUND Liver transplantation (LT) is the preferred treatment for patients with cirrhosis who have hepatopulmonary syndrome (HPS). However, effect of HPS on LT remains controversial. We assessed correlation between severity and survival compared incidence postoperative complications without undergoing LT. MATERIAL AND METHODS retrospectively reviewed recipients received living-donor in our institute January 2016 July 2019. Patients (HPS group) (non-HPS were included study. defined as a...
Tyrosine kinase inhibitors (TKIs) remain the primary therapeutic option for patients with advanced-stage hepatocellular carcinoma (HCC). However, selection of a suitable TKI is an issue in real-world clinical practice. Thus, this study aimed to identify most likely benefit from lenvatinib treatment.A retrospective review 143 unresectable HCC treated between January 2020 and December 2021 was performed. Outcomes related treatment were measured, parameters affecting prognosis analyzed.Overall,...
The outcomes and management of hepatocellular carcinoma (HCC) have undergone several evolutionary changes. This study aimed to analyze the patients who had liver resection for HCC with portal vein tumor thrombosis (PVTT) in terms evolving era treatment.A retrospective analysis 157 associated PVTT was performed. prognostic factors related different eras were further examined.Overall, 129 (82.1%) encountered recurrence after resection, median time 4.1 months. Maximum size ≥ 5 cm main trunk...
Loco-regional therapy for hepatocellular carcinoma (HCC) during the period awaiting liver transplantation (LT) appears to be a logical approach reduce risk of tumor progression and dropout in waitlist. Living donor LT (LDLT) offers flexible timing providing timeframe well preparation transplantation.To investigate outcomes relation intention pre-transplantation loco-regional LDLT HCC patients.A total 308 consecutive patients undergoing LDLTs between August 2004 December 2018 were...
Background: The scarcity of deceased donor organ donation has led to increasing utilization living liver transplantation (LDLT), which is an optimal treatment for cirrhosis associated with hepatocellular carcinoma (HCC). study thus aims analyze prognostic factors and beneficial effects LDLT patients HCC. Methods: All who underwent HCC were included in this study. A multivariate analysis patients' clinicopathologic parameters was performed determine factors. Subsequently, the type further...
More and more aged people are undergoing organ transplantation. Understanding aging effects on immunity will be helpful for post-transplantation care adjustment of immunosuppressants recipients. A mouse model, using C3H mice as donors aged/young C57BL/10J recipients, was employed to study immunity. The results showed that frequency myeloid-derived suppressor cells (MDSC) level TGF-β higher in than young (4.4 ± 1.4% versus 1.6 1.1%,
Abstract Background Therapeutic effect and immunosuppressor cell alteration in adding transcatheter arterial chemoembolization (TACE) to sorafenib for advanced stage hepatocellular carcinoma (HCC) remain unclear. Aims To examine the therapeutic TACE sorafenib. Methods Forty‐four HCC patients were divided into group A (n = 17) treated by (400‐600 mg/day) alone B 27) TACE. The frequency of regulatory T‐cells myeloid‐derived suppressor cells (MDSC), patients' outcomes examined. Advanced...
Background: The therapeutic efficacy of dendritic cell (DC)-immunotherapy for large hepatoma in mice is unsatisfactory. Materials & methods: DC-based immunotherapy was used to treat Hepa1-6 tumors measuring 6 ± 1 mm diameter, enhanced by boosting tumor antigens. Results: CD4+ and CD8+ T-cells were contracted transformed into memory phenotypic cells after vaccination. When re-stimulated, obtained from boosted antigen injection showed highest proliferation capacity. with treated, vaccination...
A novel single-photon differential phase-shift keying (DPSK) scheme with asymmetric high-bit-rate coding (at 192 Mbit/s) and low-bit-rate gating (1 data format is proposed to stabilize the long-term long-distant point-to-point secure communication over 40-km standard single-mode-fiber (SSMF). The carrier served by an attenuated distributed-feedback laser diode ultralow phase power fluctuations of Δθ/θ<0.005% ΔP/P<0.01%. successively encoded pulsed return-to-zero (RZ) clock DPSK bits at...
Conventional orthotopic implantation of left liver grafts is technically demanding and requires consideration limited space vascular complications. The study proposed a modified approach termed "left at right" transplantation (LAR-LT), wherein were rotated implanted in right subphrenic spaces. selection recipients for this based on the measurement width graft length, which could be comfortably placed space. A total 36 who had undergone LAR-LT between July 2006 December 2017 retrospectively...
Liver transplant recipients on chronic immunosuppression show an attenuated antibody response after SARS-CoV-2 vaccination. Adjusting immunosuppressants during vaccination remains debated. We enrolled 380 liver receiving 2 doses of a protein subunit, mRNA, or vector vaccine. The patients were informed to temporarily suspend for weeks both doses. measured anti-live-SARS-CoV-2 spike neutralizing levels at 1−2 months the second vaccination; 83.9% had humoral responses (SARS-CoV-2 NT50 ≥ 9.62...
BACKGROUND Duct-to-duct biliary reconstruction has been increasingly used in living-donor liver transplantation. Information regarding dual duct-to-duct anastomoses is limited. We present the largest case series to date on use of cystic and common hepatic ducts as dual-ductal anastomosis, along with long-term follow-up results. MATERIAL AND METHODS In this study, 740 patients underwent right-lobe transplantation; 56 them were documented anastomoses. analyzed recipient donor characteristics,...