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Michael A. Wheeler

ORCID: 0000-0002-0689-6384
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About
Contact & Profiles
A5035185964
Research Areas
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Immune cells in cancer
  • Single-cell and spatial transcriptomics
  • Tryptophan and brain disorders
  • interferon and immune responses
  • Immune Cell Function and Interaction
  • Neurogenesis and neuroplasticity mechanisms
  • Immune Response and Inflammation
  • Multiple Sclerosis Research Studies
  • CRISPR and Genetic Engineering
  • Sphingolipid Metabolism and Signaling
  • Viral Infections and Vectors
  • Stress Responses and Cortisol
  • IL-33, ST2, and ILC Pathways
  • Neuroscience and Neuropharmacology Research
  • Mosquito-borne diseases and control
  • Neural dynamics and brain function
  • Epigenetics and DNA Methylation
  • Immunotherapy and Immune Responses
  • Axon Guidance and Neuronal Signaling
  • T-cell and B-cell Immunology
  • HIV Research and Treatment
  • Immune responses and vaccinations
  • Lysosomal Storage Disorders Research
  • Psoriasis: Treatment and Pathogenesis

Broad Institute
 2020-2025

Brigham and Women's Hospital
 2017-2025

Harvard University
 2017-2025

Massachusetts General Hospital
 2025

University of Arkansas at Fayetteville
 2024

Colorado State University
 2024

Tufts University
 2024

University of Virginia
 2014-2019

Johns Hopkins Medicine
 2011

Johns Hopkins University
 2011

 Microglial control of astrocytes in response to microbial metabolites
OPENALEX - Publications 
Veit Rothhammer Davis Borucki Emily Tjon Maisa C. Takenaka Chun‐Cheih Chao and 16 more Alberto Ardura-Fabregat Kalil Alves de Lima Cristina Gutiérrez‐Vázquez Patrick Hewson Ori Staszewski Manon Blain Luke M. Healy Tradite Neziraj Matilde Borio Michael A. Wheeler Loic Lionel Dragin David Laplaud Jack P. Antel Jorge I. Alvarez Marco Prinz Francisco J. Quintana

10.1038/s41586-018-0119-x article EN Nature 2018-05-01
 In Vivo Clonal Analysis Reveals Self-Renewing and Multipotent Adult Neural Stem Cell Characteristics
OPENALEX - Publications 
Michael A. Bonaguidi Michael A. Wheeler Jason Shapiro Ryan P. Stadel Gerald J. Sun and 2 more Guo‐li Ming Hongjun Song

10.1016/j.cell.2011.05.024 article EN publisher-specific-oa Cell 2011-06-01
 Negative feedback control of neuronal activity by microglia
OPENALEX - Publications 
Ana Badimon Hayley J. Strasburger Pinar Ayata Xinhong Chen Aditya Nair and 25 more Ako Ikegami Philip Hwang Andrew Chan Steven M. Graves Joseph O. Uweru Carola Ledderose Munir Gunes Kutlu Michael A. Wheeler Anat Kahan Masago Ishikawa Ying‐Chih Wang Yong‐Hwee Eddie Loh Jean X. Jiang D. James Surmeier Simon C. Robson Wolfgang G. Junger Robert Sebra Erin S. Calipari Paul J. Kenny Ukpong B. Eyo Marco Colonna Francisco J. Quintana Hiroaki Wake Viviana Gradinaru Anne Schaefer

10.1038/s41586-020-2777-8 article EN Nature 2020-09-30
 Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39
OPENALEX - Publications 
Maisa C. Takenaka Galina Gabriely Veit Rothhammer Iván Mascanfroni Michael A. Wheeler and 22 more Chun‐Cheih Chao Cristina Gutiérrez‐Vázquez Jessica E. Kenison Emily Tjon Andréia Barroso Tyler Vandeventer Kalil Alves de Lima Sonja Rothweiler Lior Mayo Soufiene Ghannam Stéphanie Zandee Luke M. Healy David H. Sherr Mauricio Farez Alexandre Prat Jack P. Antel David A. Reardon Hailei Zhang Simon C. Robson Gad Getz Howard L. Weiner Francisco J. Quintana

10.1038/s41593-019-0370-y article EN Nature Neuroscience 2019-04-08
 MAFG-driven astrocytes promote CNS inflammation
OPENALEX - Publications 
Michael A. Wheeler Iain C. Clark Emily Tjon Zhaorong Li Stéphanie Zandee and 17 more Charles P. Couturier Brianna R. Watson Giulia Scalisi Sarah Alkwai Veit Rothhammer Assaf Rotem John A. Heyman Shravan Thaploo Liliana M. Sanmarco Jiannis Ragoussis David A. Weitz Kevin Petrecca Jeffrey R. Moffitt Burkhard Becher Jack P. Antel Alexandre Prat Francisco J. Quintana

10.1038/s41586-020-1999-0 article EN Nature 2020-02-12
 Genetically targeted magnetic control of the nervous system
OPENALEX - Publications 
Michael A. Wheeler Cody J. Smith Matteo Ottolini Bryan S. Barker Aarti M. Purohit and 8 more Ryan M. Grippo Ronald P. Gaykema Anthony Spano Mark P. Beenhakker Sarah Kucenas Manoj K. Patel Christopher D. Deppmann Ali D. Güler

10.1038/nn.4265 article EN Nature Neuroscience 2016-03-07
 Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
OPENALEX - Publications 
Liliana M. Sanmarco Michael A. Wheeler Cristina Gutiérrez‐Vázquez Carolina Manganeli Polonio Mathias Linnerbauer and 13 more Felipe A. Pinho‐Ribeiro Zhaorong Li Federico Giovannoni Katelyn V. Batterman Giulia Scalisi Stéphanie Zandee Evelyn S. Heck Moneera Alsuwailm Douglas L. Rosene Burkhard Becher Isaac M. Chiu Alexandre Prat Francisco J. Quintana

10.1038/s41586-020-03116-4 article EN Nature 2021-01-06
 Barcoded viral tracing of single-cell interactions in central nervous system inflammation
OPENALEX - Publications 
Iain C. Clark Cristina Gutiérrez‐Vázquez Michael A. Wheeler Zhaorong Li Veit Rothhammer and 26 more Mathias Linnerbauer Liliana M. Sanmarco Lydia Guo Manon Blain Stéphanie Zandee Chun‐Cheih Chao Katelyn V. Batterman Marius Schwabenland Peter Lotfy Amalia Tejeda Velarde Patrick Hewson Carolina Manganeli Polonio Michael W. Shultis Yasmin Salem Emily Tjon Pedro H. Fonseca-Castro Davis Borucki Kalil Alves de Lima Agustín Plasencia Adam R. Abate Douglas L. Rosene Kevin J. Hodgetts Marco Prinz Jack P. Antel Alexandre Prat Francisco J. Quintana

Single-cell analysis of CNS interactions Despite their importance in the physiology and pathology central nervous system (CNS), few methods are available for unbiased, systematic investigation cell-to-cell at single-cell resolution. Clark et al. developed RABID-seq, a method that combines barcoded viral tracing with RNA sequencing (see Perspective by Silvin Ginhoux). RABID-seq identified axon guidance molecules Sema4D-PlexinB2 EphrinB3-EphB3 as mediators microglia-astrocyte promote...

10.1126/science.abf1230 article EN Science 2021-04-22
 Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation
OPENALEX - Publications 
Michael A. Wheeler Merja Jaronen Ruxandra Covacu Stéphanie Zandee Giulia Scalisi and 13 more Veit Rothhammer Emily Tjon Chun‐Cheih Chao Jessica E. Kenison Manon Blain Vijayaraghava T.S. Rao Patrick Hewson Andréia Barroso Cristina Gutiérrez‐Vázquez Alexandre Prat Jack P. Antel Russ Hauser Francisco J. Quintana

10.1016/j.cell.2018.12.012 article EN publisher-specific-oa Cell 2019-01-01
 Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS
OPENALEX - Publications 
Chun‐Cheih Chao Cristina Gutiérrez‐Vázquez Veit Rothhammer Lior Mayo Michael A. Wheeler and 16 more Emily Tjon Stéphanie Zandee Manon Blain Kalil Alves de Lima Maisa C. Takenaka Julián Ávila-Pacheco Patrick Hewson Lei Liu Liliana M. Sanmarco Davis Borucki Gabriel Z. Lipof Sunia A. Trauger Clary B. Clish Jack P. Antel Alexandre Prat Francisco J. Quintana

10.1016/j.cell.2019.11.016 article EN publisher-specific-oa Cell 2019-12-01
 Identification of environmental factors that promote intestinal inflammation
OPENALEX - Publications 
Liliana M. Sanmarco Chun‐Cheih Chao Yu‐Chao Wang Jessica E. Kenison Zhaorong Li and 38 more Joseph M. Rone Claudia M. Rejano-Gordillo Carolina Manganeli Polonio Cristina Gutiérrez‐Vázquez Gavin Piester Agustín Plasencia Lucinda Li Federico Giovannoni Hong‐Gyun Lee Camilo Faust Akl Michael A. Wheeler Iván Mascanfroni Merja Jaronen Moneera Alsuwailm Patrick Hewson Ada Yeste Brian M. Andersen Diana G. Franks Chien-Jung Huang Millicent N. Ekwudo Emily Tjon Veit Rothhammer Maisa C. Takenaka Kalil Alves de Lima Mathias Linnerbauer Lydia Guo Ruxandra Covacu Hugo Queva Pedro H. Fonseca-Castro Maha Al Bladi Laura M. Cox Kevin J. Hodgetts Mark E. Hahn Alexander Mildner Joshua R. Korzenik Russ Hauser Scott B. Snapper Francisco J. Quintana

10.1038/s41586-022-05308-6 article EN Nature 2022-10-20
 Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells
OPENALEX - Publications 
Liliana M. Sanmarco Joseph M. Rone Carolina Manganeli Polonio Gonzalo Fernandez Lahore Federico Giovannoni and 30 more Kylynne Ferrara Cristina Gutiérrez‐Vázquez Ning Li Anna Sokolovska Agustín Plasencia Camilo Faust Akl Payal Nanda Evelin S. Heck Zhaorong Li Hong‐Gyun Lee Chun‐Cheih Chao Claudia M. Rejano-Gordillo Pedro H. Fonseca-Castro Tomer Illouz Mathias Linnerbauer Jessica E. Kenison Rocky Barilla Daniel Farrenkopf Nikolas A. Stevens Gavin Piester Elizabeth N. Chung Lucas Dailey Vijay K. Kuchroo David L. Hava Michael A. Wheeler Clary B. Clish Roni Nowarski Eduardo Balsa José M. Lora Francisco J. Quintana

10.1038/s41586-023-06409-6 article EN Nature 2023-08-09
 Droplet-based forward genetic screening of astrocyte–microglia cross-talk
OPENALEX - Publications 
Michael A. Wheeler Iain C. Clark Hong‐Gyun Lee Zhaorong Li Mathias Linnerbauer and 26 more Joseph M. Rone Manon Blain Camilo Faust Akl Gavin Piester Federico Giovannoni Marc Charabati Joon-Hyuk Lee Yoon-Chul Kye Joshua Choi Liliana M. Sanmarco Lena Srun Elizabeth N. Chung Lucas E. Flausino Brian M. Andersen Veit Rothhammer Hiroshi Yano Tomer Illouz Stéphanie Zandee Carolin Daniel David Artis Marco Prinz Adam R. Abate Vijay K. Kuchroo Jack P. Antel Alexandre Prat Francisco J. Quintana

Cell-cell interactions in the central nervous system play important roles neurologic diseases. However, little is known about specific molecular pathways involved, and methods for their systematic identification are limited. Here, we developed a forward genetic screening platform that combines CRISPR-Cas9 perturbations, cell coculture picoliter droplets, microfluidic-based fluorescence-activated droplet sorting to identify mechanisms of cell-cell communication. We used SPEAC-seq (systematic...

10.1126/science.abq4822 article EN Science 2023-03-10
 HIV silencing and cell survival signatures in infected T cell reservoirs
OPENALEX - Publications 
Iain C. Clark Prakriti Mudvari Shravan Thaploo S. Abigail Smith Mohammad Abu‐Laban and 20 more Mehdi S. Hamouda Marc Theberge Sakshi Shah Sung Hee Ko Liliana Pérez Daniel Bunis James Lee Divya Kilam Saami Zakaria Sally H.J. Choi Samuel Darko Amy R. Henry Michael A. Wheeler Rebecca Hoh Salwan Butrus Steven G. Deeks Francisco J. Quintana Daniel C. Douek Adam R. Abate Eli Boritz

Rare CD4 T cells that contain HIV under antiretroviral therapy represent an important barrier to cure

10.1038/s41586-022-05556-6 article EN cc-by Nature 2023-01-04
 Identification of astrocyte regulators by nucleic acid cytometry
OPENALEX - Publications 
Iain C. Clark Michael A. Wheeler Hong‐Gyun Lee Zhaorong Li Liliana M. Sanmarco and 16 more Shravan Thaploo Carolina Manganeli Polonio Seung Won Shin Giulia Scalisi Amy R. Henry Joseph M. Rone Federico Giovannoni Marc Charabati Camilo Faust Akl Dulce M. Aleman Stéphanie Zandee Alexandre Prat Daniel C. Douek Eli Boritz Francisco J. Quintana Adam R. Abate

10.1038/s41586-022-05613-0 article EN Nature 2023-01-04
 Disease-associated astrocyte epigenetic memory promotes CNS pathology
OPENALEX - Publications 
Hong‐Gyun Lee Joseph M. Rone Zhaorong Li Camilo Faust Akl Seungwon Shin and 19 more Joon-Hyuk Lee Lucas E. Flausino Florian Pernin Chun‐Cheih Chao Kilian Kleemann Lena Srun Tomer Illouz Federico Giovannoni Marc Charabati Liliana M. Sanmarco Jessica E. Kenison Gavin Piester Stéphanie Zandee Jack P. Antel Veit Rothhammer Michael A. Wheeler Alexandre Prat Iain C. Clark Francisco J. Quintana

10.1038/s41586-024-07187-5 article EN Nature 2024-03-20
 AHR is a Zika virus host factor and a candidate target for antiviral therapy
OPENALEX - Publications 
Federico Giovannoni Irene Bosch Carolina Manganeli Polonio María F. Torti Michael A. Wheeler and 20 more Zhaorong Li Leonardo Romorini María S. Rodriguez Varela Veit Rothhammer Andréia Barroso Emily Tjon Liliana M. Sanmarco Maisa C. Takenaka Seyed Mohamad Sadegh Modaresi Cristina Gutiérrez‐Vázquez Nágela Ghabdan Zanluqui Nilton Barreto dos Santos Carolina Demarchi Munhoz Zhongyan Wang Elsa B. Damonte David H. Sherr Lee Gehrke Jean Pierre Schatzmann Peron Cybele C. Garcı́a Francisco J. Quintana

10.1038/s41593-020-0664-0 article EN Nature Neuroscience 2020-07-20
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