A5088624872- Neuroinflammation and Neurodegeneration Mechanisms
- Adenosine and Purinergic Signaling
- Neuroscience and Neuropharmacology Research
- Immune cells in cancer
- Barrier Structure and Function Studies
- Immune Response and Inflammation
University of Virginia
2019-2023
Abstract Microglia are brain-resident immune cells with a repertoire of functions in the brain. However, extent their interactions vasculature and potential regulation vascular physiology has been insufficiently explored. Here, we document between ramified CX3CR1 + myeloid cell somata brain capillaries. We confirm that these bona fide microglia by molecular, morphological ultrastructural approaches. Then, give detailed spatio-temporal characterization capillary-associated (CAMs) comparing...
Abstract Microglia, the primary immune cells of central nervous system (CNS), are derived from yolk sac and populate brain during development. Once microglia migrate to CNS, they self-renewing require CSF1R signaling for their maintenance. Pexidartinib (PLX3397, PLX), a small molecule inhibitor CSF1R, has been shown effectively deplete since microglial maintenance is CSF1R-dependent. There have, however, several conflicting reports that have potential off-target effects PLX on peripheral...
Seizure disorders are common, affecting both the young and old. Currently available antiseizure drugs ineffective in a third of patients have been developed with focus on known neurocentric mechanisms, raising need for investigations into alternative complementary mechanisms that contribute to seizure generation or its containment. Neuroinflammation, broadly defined as activation immune cells molecules central nervous system (CNS), has proposed facilitate generation, although specific...
Abstract Microglia are brain-resident immune cells with a repertoire of functions in the developing, mature and pathological brain. Their wide-ranging roles physiology include clearance cellular debris, elimination excess synapses, regulation neuronal activity contributions to blood vessel development. Despite these known for microglia, extent their interactions vasculature potential vascular has been insufficiently explored. Here, using vivo acute longitudinal two-photon imaging transgenic...
Abstract Seizure disorders are common, affecting both the young and old. Currently available antiseizure drugs ineffective in a third of patients have been developed with focus on known neurocentric mechanisms, raising need for investigations into alternative complementary mechanisms that contribute to seizure generation or its containment. Neuroinflammation, broadly defined as activation immune cells molecules central nervous system (CNS), has proposed facilitate generation, although...