A5026949255- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- Birth, Development, and Health
- Neuroscience and Neuropharmacology Research
- Renal Transplantation Outcomes and Treatments
- Stress Responses and Cortisol
- Adenosine and Purinergic Signaling
- Neuroendocrine regulation and behavior
- MicroRNA in disease regulation
- Animal Disease Management and Epidemiology
- Pharmacological Effects and Toxicity Studies
- Organ Transplantation Techniques and Outcomes
- Cancer-related molecular mechanisms research
- HIV/AIDS drug development and treatment
- Liver Disease and Transplantation
- Drug Transport and Resistance Mechanisms
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Poxvirus research and outbreaks
Duke University
2021-2024
Duke University Hospital
2021-2022
Duke Medical Center
2021-2022
University of Virginia
2020-2021
Universidade de São Paulo
2018-2021
National University of San Marcos
2018-2019
Abstract Microglia are brain-resident immune cells with a repertoire of functions in the brain. However, extent their interactions vasculature and potential regulation vascular physiology has been insufficiently explored. Here, we document between ramified CX3CR1 + myeloid cell somata brain capillaries. We confirm that these bona fide microglia by molecular, morphological ultrastructural approaches. Then, give detailed spatio-temporal characterization capillary-associated (CAMs) comparing...
Although an imbalance between neuronal excitation and inhibition underlies seizures, clinical approaches that target these mechanisms are insufficient in containing seizures patients with epilepsy, raising the need for alternative approaches. Brain-resident microglia contribute to development stability of structure functional networks perturbed during seizures. However, extent microglial contributions response vivo remain be elucidated. Using two-photon imaging visualize dynamics, we show...
Gastrointestinal (GI) dysfunction is a frequently reported comorbidity of neurodevelopmental disorders (NDDs). Early-life inflammatory challenges from the environment (e.g. infection, toxicants) can increase risk for NDDs but impact such stressors on developing GI tract not well understood. We investigated possible mechanisms by which comorbidities occur in response to environmental using our well-characterized model combined gestational exposure air pollution (diesel exhaust particles, DEP)...
This study explored circulating miRNAs and target genes associated with metabolic syndrome (MetS) cardiometabolic risk in obese patients. Small-RNA sequencing was used to assess the peripheral blood miRNome of 12 subjects (6 MetS 6 non-MetS). Differentially expressed were further analyzed by qPCR a larger sample patients (48 32 miRNA:mRNA interactions studied using silico tools. analysis identified 10 downregulated compared non-Met (p < 0.05). In studies revealed three (miR-155, miR-181a,...
Avipoxvirus affects chickens and wild birds, it is characterized by lesions on the nonfeathered parts of body (the cutaneous form), or necrotic in upper respiratory tract diphtheritic form). In poultry farming, avian pox usually controlled live attenuated vaccines. However, there have been many reports outbreaks, even flocks vaccinated birds. present study, different outbreaks emerging clade E avipoxvirus were detected commercial breeder against fowlpox virus Southeast Brazil. Clinical...
Aim: The influence of variants in pharmacokinetics-related genes on long-term exposure to tacrolimus (TAC)-based therapy and clinical outcomes was investigated. Patients & methods: Brazilian kidney recipients were treated with TAC combined everolimus (n = 178) or mycophenolate sodium 97). CYP2C8, CYP2J2, CYP3A4, CYP3A5, POR, ABCB1, ABCC2, ABCG2, SLCO1B1 SLCO2B1 analyzed. Main results: CYP3A5*3/*3 genotype influenced increase concentration from week 1 month 6 post-transplantation (p < 0.05)....
Monitoring of immunosuppressive drugs, such as calcineurin and mTOR inhibitors, is essential to avoid undesirable kidney transplant outcomes. Polymorphisms in pharmacokinetics-related genes have been associated with variability blood levels drugs adverse effects, but influence pharmacodynamics-related remains be elucidated. The polymorphisms the signaling pathways on long-term clinical outcomes was investigated Brazilian recipients within 1-year post-transplant. Two-hundred sixty-nine were...
SUMMARY High maternal weight is associated with a number of detrimental outcomes in offspring, including increased susceptibility to neurological disorders such as anxiety, depression, and communicative (e.g. autism spectrum disorders) 1–8 . Despite widespread acknowledgement sex-biases the prevalence, incidence, age onset these disorders, few studies have investigated potential sex-biased mechanisms underlying disorder susceptibility. Here, we use mouse model demonstrate how high-fat diet,...
Introduction: Esophageal varices represent one of the main complications in patients with liver cirrhosis. The objective was to determine diagnostic performance new Baveno VII criteria exclude presence esophageal compensated advanced chronic disease (cACLD), an independent Peruvian population. Materials and methods: A cross-sectional study, including cACLD, upper digestive endoscopy, transient hepatic elastography from January 2017 December 2019. Results: mean age 59.4 (12.9) years, while...
Abstract Microglia are brain-resident immune cells with a repertoire of functions in the developing, mature and pathological brain. Their wide-ranging roles physiology include clearance cellular debris, elimination excess synapses, regulation neuronal activity contributions to blood vessel development. Despite these known for microglia, extent their interactions vasculature potential vascular has been insufficiently explored. Here, using vivo acute longitudinal two-photon imaging transgenic...
Although an imbalance between neuronal excitation and inhibition underlies seizures, clinical approaches that target these mechanisms are insufficient in containing seizures epileptic patients raising the need for alternative approaches. Brain-resident microglia contribute to development stability of structure functional networks perturbed during seizures. However, extent microglial contributions response vivo remain be elucidated. Using two photon imaging visualize dynamics, we show severe...