A5075097545- Neuroinflammation and Neurodegeneration Mechanisms
- Birth, Development, and Health
- Stress Responses and Cortisol
- Gut microbiota and health
- Neuroendocrine regulation and behavior
- Pregnancy and preeclampsia studies
- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Immune cells in cancer
- Maternal Mental Health During Pregnancy and Postpartum
- Child Nutrition and Water Access
- Folate and B Vitamins Research
- Reproductive System and Pregnancy
- Neuroscience and Neuropharmacology Research
- Neurological diseases and metabolism
- Urological Disorders and Treatments
- Immune Response and Inflammation
- Single-cell and spatial transcriptomics
- Parkinson's Disease Mechanisms and Treatments
- Ethics in Clinical Research
- Neurogenesis and neuroplasticity mechanisms
Duke University
2021-2024
Maternal immune activation is associated with adverse offspring neurodevelopmental outcomes, many mediated by in utero microglial programming. As microglia remain inaccessible throughout development, identification of noninvasive biomarkers reflecting fetal brain programming could permit screening and intervention. We used lineage tracing to demonstrate the shared ontogeny between macrophages (microglia) placental (Hofbauer cells) a mouse model maternal diet-induced obesity, single-cell...
Gastrointestinal (GI) dysfunction is a frequently reported comorbidity of neurodevelopmental disorders (NDDs). Early-life inflammatory challenges from the environment (e.g. infection, toxicants) can increase risk for NDDs but impact such stressors on developing GI tract not well understood. We investigated possible mechanisms by which comorbidities occur in response to environmental using our well-characterized model combined gestational exposure air pollution (diesel exhaust particles, DEP)...
Neuron-microglia interactions dictate the development of neuronal circuits in brain. However, factors that support and broadly regulate these processes across developmental stages are largely unknown. Here, we find IL34, a neuron-derived cytokine, is upregulated plays critical role supporting maintaining neuroprotective, mature microglia anterior cingulate cortex (ACC) mice. We show IL34 mRNA protein neurons second week postnatal life this increase coincides with increases number expression...
Maternal immune activation is associated with adverse offspring neurodevelopmental outcomes, many mediated by in utero microglial programming. As microglia remain inaccessible throughout development, identification of noninvasive biomarkers reflecting fetal brain programming could permit screening and intervention. We used lineage tracing to demonstrate the shared ontogeny between macrophages (microglia) placental (Hofbauer cells) a mouse model maternal diet-induced obesity, single-cell...
SUMMARY High maternal weight is associated with a number of detrimental outcomes in offspring, including increased susceptibility to neurological disorders such as anxiety, depression, and communicative (e.g. autism spectrum disorders) 1–8 . Despite widespread acknowledgement sex-biases the prevalence, incidence, age onset these disorders, few studies have investigated potential sex-biased mechanisms underlying disorder susceptibility. Here, we use mouse model demonstrate how high-fat diet,...
Maternal immune activation is associated with adverse offspring neurodevelopmental outcomes, many of which are mediated by in utero microglial programming. Microglia remain inaccessible at birth and throughout development, thus identification noninvasive biomarkers that can reflect fetal brain programming may permit screening intervention during critical developmental windows. Here we used lineage tracing to demonstrate the shared ontogeny between macrophages (microglia) placental (Hofbauer...
Summary Maternal immune activation is associated with adverse offspring neurodevelopmental outcomes, many of which are mediated by in utero microglial programming. Microglia remain inaccessible at birth and throughout development, thus identification noninvasive biomarkers that can reflect fetal brain programming may permit screening intervention during critical developmental windows. Here we used lineage tracing to demonstrate the shared ontogeny between macrophages (microglia) placental...
Abstract Environmental toxicant exposure, including air pollution, is increasing worldwide. However, exposures are not equitably distributed. Rather, low-income and minority communities bear the greatest burden, along with higher levels of psychosocial stress. Both pollution maternal stress during pregnancy have been linked to neurodevelopmental disorders such as autism, but biological mechanisms targets for therapeutic intervention remain poorly understood. We demonstrate that combined...
Abstract Understanding the mechanisms underlying amyotrophic lateral sclerosis (ALS) is crucial for development of new therapies. Recent evidence suggest that tau may be involved in ALS pathogenesis. Here, we demonstrated hyperphosphorylated (pTau-S396) mis-localized to synapses human post-mortem motor cortex (mCTX) across subtypes. Treatment with synaptoneurosomes (SNs) derived from mCTX, enriched pTau-S396, increased oxidative stress, induced mitochondrial fragmentation, and altered...
Environmental toxicant exposure, including air pollution, is increasing worldwide. However, exposures are not equitably distributed. Rather, low-income and minority communities bear the greatest burden, along with higher levels of psychosocial stress. Both pollution maternal stress during pregnancy have been linked to neurodevelopmental disorders such as autism, but biological mechanisms targets for therapeutic intervention remain poorly understood. We demonstrate that combined prenatal...