A5007335384- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Pregnancy and preeclampsia studies
- Assisted Reproductive Technology and Twin Pregnancy
- Birth, Development, and Health
- COVID-19 Impact on Reproduction
- Neuroinflammation and Neurodegeneration Mechanisms
- Maternal and fetal healthcare
- Alzheimer's disease research and treatments
- Ectopic Pregnancy Diagnosis and Management
- Genomic variations and chromosomal abnormalities
- RNA regulation and disease
- Neurological diseases and metabolism
- Genetic Neurodegenerative Diseases
- Pediatric Hepatobiliary Diseases and Treatments
- Chromosomal and Genetic Variations
- Pregnancy and Medication Impact
- Genomics and Chromatin Dynamics
- Facial Rejuvenation and Surgery Techniques
- Prenatal Screening and Diagnostics
- Mitochondrial Function and Pathology
- Neurological disorders and treatments
- Public Policy and Administration Research
- Histone Deacetylase Inhibitors Research
- Science Education and Perceptions
Icahn School of Medicine at Mount Sinai
2022-2025
Mass General Brigham
2023
Skin Research Center
2023
Massachusetts General Hospital
2019-2021
Boston College
2016-2021
Yale University
2016
Concordia University
2015
Abstract Background Recent meta-analyses showed that around 30% of women suffered postpartum depression during the COVID-19 pandemic, a two-fold increase compared to before pandemic (1,2,3). The immune system plays key role in responding infections, and is potential mechanism development psychiatric disorders. placenta driver changes pregnancy, modulating maternal response perinatal infections (4). Aims & Objectives To investigate: 1) whether SARS-CoV2 infection pregnancy associated with...
Objective: To investigate odds of vaginal delivery comparing induced versus spontaneous labor in nulliparas and multiparas with dichorionic twins. Study Design: Retrospective review twin pregnancies from 2008-2021. Those scheduled or elective cesarean, malpresentation, prior uterine surgery, fetal anomaly, gestational age (GA) at < 34 weeks, multifetal reduction were excluded. Nulliparas analyzed separately. The primary outcome was both Secondary outcomes included preterm delivery,...
Amy Bird, BAMAN Chair, and Alexandra Mills, Vice-Chair discuss the evolution of
Neuroinflammation plays a pathogenic role in neurodegenerative diseases and recent findings suggest that it may also be involved X-linked Dystonia-Parkinsonism (XDP) pathogenesis. Previously, fibroblasts neuronal stem cells derived from XDP patients demonstrated hypersensitivity to TNF-α, dysregulation NFκB signaling, an increase several pro-inflammatory markers. However, the of inflammatory processes patient brain remains unknown. Here we demonstrate there is significant astrogliosis...
Abstract Accumulating evidence suggests that neuroinflammatory processes are implicated in the initiation and progression of amyotrophic lateral sclerosis (ALS). Previous reports have demonstrated an increase microgliosis astrogliosis lumbar spinal cord SOD1 G93A transgenic mice before onset symptoms, a response which correlated with disease progression. Importantly, early stage homeostatic microglia enhanced motor neuron survival, while pro-inflammatory were toxic to neurons mice. Recent...
Abstract Although the molecular mechanisms underlying amyotrophic lateral sclerosis (ALS) are not yet fully understood, several studies report alterations in tau phosphorylation both sporadic and familial ALS. Recently, we have demonstrated that phosphorylated at S396 (pTau‐S396) is mislocalized to synapses ALS motor cortex (mCTX) contributes mitochondrial dysfunction. Here, demonstrate while there was no overall increase total tau, pTau‐S396, pTau‐S404 post‐mortem mCTX, pTau‐S396 were...
Wolf-Hirschhorn Syndrome (WHS) is a human developmental disorder arising from hemizygous perturbation, typically microdeletion, on the short arm of chromosome four. In addition to pronounced intellectual disability, seizures, and delayed growth, WHS presents with characteristic facial dysmorphism varying prevalence microcephaly, micrognathia, cartilage malformation in ear nose, asymmetries. These affected craniofacial tissues all derive shared embryonic precursor, cranial neural crest (CNC),...
Libraries and archives digitize their special collections in an effort to increase access rare unique items. To ensure that resulting digital meet user needs, institutions have made assessment, consultation, participation integral digitization initiatives the selection process. Institutions must also build reflect priorities. This article examines impact on process of developing useful usable balance institutional interests while satisfying needs key stakeholders.
The exact mechanisms underlying neuroinflammation and how they contribute to amyotrophic lateral sclerosis (ALS) pathogenesis remain unclear. One possibility is the secretion of neurotoxic factors, such as lipocalin-2 (LCN2), that lead neuronal death.LCN2 levels were measured in human postmortem tissue using Western blot, quantitative real time polymerase chain reaction, immunofluorescence, plasma by enzyme-linked immunosorbent assay. SH-SY5Y cells used test pro-inflammatory effects...
Microtubule dynamics is regulated by plus end-tracking proteins (+TIPs), which localize to the ends of microtubules (MTs). We previously showed that TACC1 and TACC3, members transforming acidic coiled-coil protein family, can act as +TIPs regulate MT in Xenopus laevis Here we characterize TACC2 a +TIP localizes front EB1 overlapping with TACC3 multiple embryonic cell types. also show promote polymerization mesenchymal cells but not neuronal growth cones, thus displaying cell-type...
X-linked Dystonia-Parkinsonism (XDP) is a neurodegenerative disease linked to an insertion of SINE-VNTR-Alu (SVA)-type retrotransposon within intron TAF1 . This SVA induces aberrant splicing and partial retention, thereby decreasing levels the full-length transcript. Here we sought determine if these altered transcriptional dynamics caused by are also accompanied local changes in histone acetylation, given that modifications influence gene expression. Because protein may itself exhibit...
To date, it is still controversial whether tau phosphorylation plays a role in Huntington's disease (HD), as previous studies demonstrated either no alterations or increases phosphorylated (pTau) HD postmortem brain and mouse models.
There is an unmet need for mechanism-based biomarkers and effective disease modifying treatments in amyotrophic lateral sclerosis (ALS). Previous findings have provided evidence that histone deacetylases (HDAC) are altered ALS, providing a rationale testing HDAC inhibitors as therapeutic option.We measured class I II protein transcript levels together with acetylation of downstream substrates by using Western blotting postmortem tissue ALS controls. [11 C]Martinostat, novel positron emission...
Self-expandable metal stent (SEMS) are widely utilized as a bridge to surgical intervention and for palliative treatment of malignant bowel obstructions. The risk complications associated with SEMS is low in well-selected patients. Stent erosion rare but serious adverse event that high morbidity mortality. Here, we report the case 74-year-old patient colonic obstruction secondary pelvic mass was treated radiotherapy, who developed partial thickness recurrent hematochezia 6 years after...