A5014233718- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
Universidade de São Paulo
2021
This study explored circulating miRNAs and target genes associated with metabolic syndrome (MetS) cardiometabolic risk in obese patients. Small-RNA sequencing was used to assess the peripheral blood miRNome of 12 subjects (6 MetS 6 non-MetS). Differentially expressed were further analyzed by qPCR a larger sample patients (48 32 miRNA:mRNA interactions studied using silico tools. analysis identified 10 downregulated compared non-Met (p < 0.05). In studies revealed three (miR-155, miR-181a,...
Aim: To explore the association of circulating miRNAs with adiposity, metabolic status and inflammatory biomarkers in patients syndrome (MetS). Methods: Serum levels 372 were measured (n = 6) without MetS by quantitative PCR array, dysregulated validated a larger cohort (MetS, n 89; non-MetS, 144). Results: In screening study, seven MetS, miR-421 remained increased validation study. was associated high risk insulin resistance hypertension correlated glycated hemoglobin, triacylglycerols,...