A5038576395- Transplantation: Methods and Outcomes
- Heart Failure Treatment and Management
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Lipoproteins and Cardiovascular Health
- Cardiac Structural Anomalies and Repair
- Nitric Oxide and Endothelin Effects
- Neuroscience and Neuropharmacology Research
- Viral Infections and Immunology Research
- Cardiac Ischemia and Reperfusion
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Genomics and Phylogenetic Studies
- Advanced MRI Techniques and Applications
- Cardiac Health and Mental Health
- Cardiac Valve Diseases and Treatments
- Adenosine and Purinergic Signaling
- Microbial Community Ecology and Physiology
- Coronary Interventions and Diagnostics
- Breast Lesions and Carcinomas
- Blood Pressure and Hypertension Studies
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
Fu Jen Catholic University
2022-2025
National Taiwan University Hospital
2012-2023
Taipei Medical University
2011-2023
National Cheng Kung University
2017-2022
Tao Yuan General Hospital
2022
Ministry of Health and Welfare
2022
Oklahoma Medical Research Foundation
2022
National Health Research Institutes
2012-2021
National Taiwan University
2008-2020
National Yang Ming Chiao Tung University
2012-2020
Inactivation of glycogen synthase kinase-3beta (GSK3beta) by S(9) phosphorylation is implicated in mechanisms neuronal survival. Phosphorylation a distinct site, Y(216), on GSK3beta necessary for its activity; however, whether this site can be regulated cells unknown. Therefore we examined the regulation Y(216) models neurodegeneration. Nerve growth factor withdrawal from differentiated PC12 and staurosporine treatment SH-SY5Y led to increased at activity, cell death. Lithium insulin, agents...
Mesenchymal stem cells (MSCs) are known for their immunomodulatory functions. We previously demonstrated that bone marrow-derived MSCs effectively control transplant arteriosclerosis (TA) by enhancing IL-10(+) and IFN-γ(+) cells. The objective of this study is to elucidate the mechanism which induce IL-10(+)IFN-γ(+)CD4(+) regulatory T type 1 (T(R)1)-like In an MLR system using porcine PBMCs, MSC-induced cells, confer resistance allogeneic proliferation in IL-10-dependent manner, resemble...
Elucidating the metabolic mechanism of gold nanoclusters (AuNCs) in bacteria will play a pivotal role bacterial detection and inhibition. A facile method to investigate AuNCs is demonstrated this work. The cysteine-conjugated (Cys-AuNCs) were successfully prepared with orange-red fluorescence, high water solubility, superior biocompatibility by one-pot green synthesis determine metabolism. suggested process was that Cys-AuNCs metabolized Escherichia coli, as verified through decrease...
Recognition sites for the uptake of norepinephrine on adrenergic neurons in brain and periphery were labeled with [ 3 H]desipramine. The number these varied concentration transmitter; depletion reserpine reduced sites, whereas increasing induced by treatment monoamine oxidase inhibitors raised binding sites. These dynamic alterations recognition may regulate synaptic function homeostatically, providing less inactivation reuptake when transmitter is low increased it high.
A mixture of post-consumer polyethylene/polypropylene/polystyrene (PE/PP/PS) with polyvinyl chloride (PVC) waste was pyrolyzed over cracking catalysts using a fluidizing reaction system operating isothermally at ambient pressure. The influences catalyst types and conditions including temperatures, ratios to plastic feed, flow rates gas particle sizes were examined. Experiments carried out various gave good yields valuable hydrocarbons differing selectivity in the final products dependent on...
Background— Endocarditis-inducing streptococci form multilayered biofilms in complex with aggregated platelets on injured heart valves, but the host factors that interconnect and entrap these bacteria-platelet aggregates to promote vegetation formation were unclear. Methods Results— In a Streptococcus mutans endocarditis rat model, we identified layers of neutrophil extracellular traps interconnecting entrapping inside could be reduced significantly size along diminished colonizing bacteria...
Interferon (IFN)-based therapies could eradicate hepatitis C (HCV) and reduce the risk of hepatocellular carcinoma (HCC). However, HCC still happen after sustained virological response (SVR). We aimed to develop a simple scoring system predict development among HCV patients antiviral therapies. From 1999 2009, 1879 with biopsy-proven infection treated IFN-based were analyzed. Multivariable analysis showed old age (adjusted HR (aHR)=1.73, 95% CI=1.13–2.65 for aged 60–69 aHR=2.20, CI=1.43–3.37...
Homocysteine (Hcy) contributes to atherogenesis and angiostasis by altering the phenotype of arterial endothelial cells (ECs). The present study was aimed at elucidating potential mechanisms which Hcy can slow EC proliferation induce apoptosis, thereby disrupting integrity. Given strong mitogenic antiapoptotic properties fibroblast growth factor (FGF)2, we examined whether modulate its expression. In cultured human coronary bovine aortic ECs, exerted time- concentration-dependent (0 500...
Cardiac allograft vasculopathy (CAV) is the major determinant of long-term survival after heart transplantation. We aimed to evaluate efficacy PET as a noninvasive way assess early stages CAV. <b>Methods:</b> Twenty-seven consecutive patients (20 men and 7 women; mean age ± SD, 46 12 y) who had normal results on coronary angiography left ventricular systolic function (ejection fraction ≥ 60%) were enrolled at 2.5 2.1 y Myocardial blood flow (MBF) was assessed using dynamic...
As an alternative strategy for cancer treatment, the combination of nanomedicine and immunotherapy is promising with regard to efficacy safety; however, precise modulation activation antitumor immunity remains challenging. Therefore, aim present study was describe intelligent nanocomposite polymer immunomodulator, drug-free polypyrrole-polyethyleneimine nanozyme (PPY-PEI NZ), which responds B-cell lymphoma tumor microenvironment, precision immunotherapy. Earlier engulfment PPY-PEI NZs in...