A5053953428- Cancer Immunotherapy and Biomarkers
- Psoriasis: Treatment and Pathogenesis
- Skin Protection and Aging
- Phytochemicals and Antioxidant Activities
- Cancer Cells and Metastasis
- Cytokine Signaling Pathways and Interactions
- Genomics, phytochemicals, and oxidative stress
- Cancer Research and Treatments
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Flavonoids in Medical Research
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
National Yang Ming Chiao Tung University
2022-2024
Taipei City Hospital
2023
Taipei Veterans General Hospital
2023
Taipei Municipal YangMing Hospital
2023
National Defense Medical Center
2018-2019
Interleukin-17 (IL-17) is a pro-inflammatory cytokine that plays vital role in the promotion of tumorigenesis various cancers, including colorectal cancer (CRC). Based on current evidence, IL-17 binds to interleukin-17 receptor A (IL-17RA); however, IL-17RA has not been elucidated previous studies CRC. In this study, we explored human CRC tissues and progression humans mice.
Increased matrix metalloproteinase 1 (MMP-1) expression is a feature of photo-aged skin. We investigated the effects baicalein and sulphoraphane on ultraviolet B (UVB) irradiation-induced MMP-1 apoptosis using human dermal fibroblasts. UVB irradiation not only increased expression, but also caused apoptosis. Both protected cells from apoptosis, inhibited expression. activated 12-lipoxygenase, its product, 12-hydroxyeicosatetraenoic acid, TRPV1 channels. The resulting Ca2+ increase was...
Insufficient prognosis of local recurrence contributes to the poor progression-free survival rate and death in colorectal cancer (CRC) patients. Various biomarkers have been explored predicting CRC recurrence. This study investigated expressions plasma/exosomal microRNA-21 (miR-21) 113 patients by qPCR, their values recurrence, possibility improve prognostic efficacy early stratified combined including circulating miR-21s, tumour cells/microemboli (CTCs/CTM), serum carcinoembryonic antigen...
Background: Circulating tumor cells (CTCs) have been investigated as a potential biomarker for predicting prognosis and monitoring therapeutic responses in colorectal cancer (CRC). However, the sensitivity of CTCs detection is low, thus limiting clinical utility CTCs. We aim to examine clinicopathological parameters that improve prediction CRC using biomarker. Methods: enumerated 186 patients associated number with features overall survival (OS) univariate multivariate Cox regression model...
Copper is more likely than iron to generate reactive oxygen species (ROS) in a redox reaction due its higher electrochemical reactivity. This study examined the effect of newly synthesized Cu 2+ binding compound, ( E )‐2‐(4‐(dimethylamino)phenylimino)methyl)quinolin‐8‐ol (DPMQ), on ultraviolet B (UVB) irradiation–induced cytotoxicity human dermal fibroblasts. DPMQ induced influx as effectively disulfiram, ionophore anticancer drug. However, disulfiram ROS generation, mitochondrial...
Abstract Background Interleukin-17 (IL-17) is a proinflammatory cytokine that plays vital role in the promotion of tumorigenesis various cancers, including colorectal cancer (CRC). Based on current evidence, IL-17 binds to interleukin-17 receptor A (IL-17RA); however, IL-17RA has not been elucidated previous studies CRC. In this study, we explored human CRC tissues and progression humans mice. Methods The expressions epithelial-mesenchymal transition (EMT)-related genes were examined cells...