A5020285377- Amino Acid Enzymes and Metabolism
- Digital Radiography and Breast Imaging
- Metabolism and Genetic Disorders
- Enzyme Structure and Function
- COVID-19 and healthcare impacts
- Global Cancer Incidence and Screening
- Enzyme Production and Characterization
- Radiology practices and education
- Ethics in Clinical Research
- American Environmental and Regional History
- Economic and Financial Impacts of Cancer
- Scientific Computing and Data Management
- Cloud Computing and Remote Desktop Technologies
- Biomedical Text Mining and Ontologies
- Medical Imaging Techniques and Applications
- Microbial Metabolites in Food Biotechnology
- Statistical Methods in Clinical Trials
- Diet, Metabolism, and Disease
- Health Systems, Economic Evaluations, Quality of Life
- Catalytic Processes in Materials Science
- Hospital Admissions and Outcomes
- Electronic Health Records Systems
- Cancer Genomics and Diagnostics
- Analytical Chemistry and Chromatography
- Bacterial Genetics and Biotechnology
Thomas Jefferson University
2007-2023
Sidney Kimmel Cancer Center
2007-2023
TriNetX (United States)
2023
National Institute of Dental and Craniofacial Research
1970-2017
National Institutes of Health
1970-2000
Fox Chase Cancer Center
1991-1995
De La Salle University
1992
Hospital of the University of Pennsylvania
1979-1985
London Library
1985
British Museum
1985
PURPOSE While there are studies under way to characterize the direct effects of COVID-19 pandemic on care patients with cancer, have been few quantitative reports impact that efforts control had normal course cancer diagnosis and treatment encounters. METHODS We used TriNetX platform analyze 20 health institutions relevant, up-to-date encounter data. Using this COVID Cancer Research Network (CCRN), we compared cohorts identified by querying data pre-COVID (January 2019-April 2019) current...
Abstract Objective This article describes a scalable, performant, sustainable global network of electronic health record data for biomedical and clinical research. Materials Methods TriNetX has created technology platform characterized by conservative security governance model that facilitates collaboration cooperation between industry participants, such as pharmaceutical companies contract research organizations, academic community-based healthcare organizations (HCOs). HCOs participate on...
The deoxyglucose technique for the measurement of local cerebral glucose metabolism (LCMRgl) has been widely applied in animals utilizing 14C-deoxyglucose and humans employing 18F-fluorodeoxyglucose. Repeat studies over a relatively brief period time have not possible because 110-min half-life fluorine-18. With synthesis 11C-deoxyglucose it now become to utilize this short-lived (20 min) tracer LCMRgl determine its variability within subjects 2-h period. kinetic rate constants were...
Liberated by enzymatic lysis of the cells, flagella Rhodospirillum rubrum, R. molischianum , and fulvum all have a similar structure. The hook at base flagellum is connected short, narrow collar to paired disc in basal organelle. This turn second disc. disposition which fragments cell membrane still adhere suggests that traverses both wall membrane, upper pair discs organelle lies just beneath surface membrane.
London, Jack (University of California, Los Angeles), and Sydney C. Rittenberg . Effects organic matter on the growth Thiobacillus intermedius J. Bacteriol. 91: 1062–1069. 1966.—Yeast extract, glucose, glutamate, other materials stimulate rate extent in thiosulfate broth. Growth did not occur glucose or glutamate mineral salts medium absence thiosulfate, although a stable variant was obtained which grows yeast extract alone. Cells harvested from media supplemented with have reduced oxidation...
Regulation of the synthesis and function an l(+)-specific lactate-oxidizing enzyme system found in a homofermentative Streptococcus was investigated. With exception fructose, aerobic growth at expense variety substrates resulted formation lactate oxidation system; anaerobic marked reduction or complete loss activity. Growth on under conditions, invariably produced decrease activity system. A negative control, activated by early intermediate product glycolysis, appeared to be responsible for...
PURPOSE This is an update to a previously published report characterizing the impact that efforts control COVID-19 pandemic have had on normal course of cancer-related encounters. METHODS Data were analyzed from 22 US health care organizations (members TriNetX global network) having relevant, up-to-date encounter data. Although original study compared data pre–COVID-19 (January-April 2019) with corresponding months in 2020, this considers through April 2021. As before, cohorts generated for...
The growth of Lactobacillus casei strain Cl-16 at the expense or ribitol was inhibited if non-metabolizable substrate xylitol included in medium concentrations 6 mM greater. At these concentrations, xylitol, did not competitively inhibit transport. cessation caused by intracellular accumulation xylitol-5-phosphate, which occurred because on had gratuitously induced a functional xylitol-specific phosphotransferase system but enzymes necessary for further metabolism xylitol-5-phosphate....
Abstract The demonstration of partial immunological identity between the fructose diphosphate aldolases Streptococcus faecalis, Lactobacillus casei, and Pediococcus cerevisiae indicated that three proteins are structurally related. Although enzymes differ markedly in molecular weight electrophoretic mobility, purified were shown to be composed subunits similar or identical size. S. faecalis aldolase, which had been characterized previously, is two 28,000 as estimated by sodium dodecyl...
The initial-velocity kinetics of hog kidney gamma-glutamyltransferase were studied. Glutamate gamma-(4-nitroanilide) and its 3-carboxy derivative, glutamate gamma-(3-carboxy-4-nitroanilide), served as gamma-glutamyl donors, glycylglycine an acceptor. Reaction products identified by paper chromatography amino acid analysis. Inhibited Ping Pong mechanisms a comprehensive initial- velocity expression developed which account for the observed simultaneous transfer autotransfer, competitive...
gamma-Glutamyltransferase (EC 2.3.2.2) from human liver, kidney, pancreas, and duodenum migrated in acrylamide gels (65 g/L) as a single band with the following decreasing order of electrophoretic mobility: liver > pancreas kidney duodenum. The initial velocity kinetic constants pancreatic duodenal gamma-glutamyltransferase enzyme serum were determined compared those we previously established for serum. greatest differences glycylglycine competitive-inhibition constants: was most strongly...
Many cancer interventional clinical trials are not completed because the required number of eligible patients enrolled.To assess value using a research data mart (RDM) during design as predictor potential patient accrual, so that less fail to meet enrollment requirements.The eligibility criteria for 90 were translated into i2b2 RDM queries and cohort sizes obtained 2 years prior trial initiation. These numbers compared accrual requirements, generating predictions success. then actual...
The phosphoenolpyruvate-dependent xylitol:phosphotransferase system of Lactobacillus casei strain C183 requires a small, soluble, substrate-specific protein for catalytic activity. Designated enzyme IIIXtl (or IIIXtl), the was purified to electrophoretic homogeneity and characterized. IIIXtl, as purified, is single polypeptide composed 109 amino acid residues. It has an estimated molecular weight 12,000 hydrophobic in nature. hydrophobicity apparently due fact that isolated phosphorylated...