A5103187461- Advanced Breast Cancer Therapies
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- HIV/AIDS Research and Interventions
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Economic and Financial Impacts of Cancer
- HIV/AIDS drug development and treatment
- Pain Management and Placebo Effect
- Pregnancy and Medication Impact
- Female Genital Mutilation/Cutting Issues
- Pharmaceutical studies and practices
- Extracellular vesicles in disease
- Healthcare cost, quality, practices
- Health, Environment, Cognitive Aging
- HIV Research and Treatment
- Risk Perception and Management
- Cervical Cancer and HPV Research
- Appendicitis Diagnosis and Management
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Global Cancer Incidence and Screening
- Sperm and Testicular Function
- HER2/EGFR in Cancer Research
- Endometrial and Cervical Cancer Treatments
TriNetX (United States)
2023
Seattle University
2022
Alfred Health
2021
University of British Columbia
2019
University Health Network
2003-2018
University of California, San Francisco
2017
Schwartz/Reisman Emergency Medicine Institute
2017
Sinai Hospital
2017
University of Ottawa
2009
Abstract Objective This article describes a scalable, performant, sustainable global network of electronic health record data for biomedical and clinical research. Materials Methods TriNetX has created technology platform characterized by conservative security governance model that facilitates collaboration cooperation between industry participants, such as pharmaceutical companies contract research organizations, academic community-based healthcare organizations (HCOs). HCOs participate on...
Background: Accurate pre-operative clinical staging is vital for guiding treatment decisions in resectable non-small cell lung cancer (NSCLC). Discrepancies between and pathological stages raise concerns about appropriateness. Objective: The objective of the study to determine accuracy stage (cTN) with post-operative (pTN), examine factors predictive inaccurate explore impacts on survival. Patient Methods: This retrospective cohort Melbourne, Australia, analyzed I-IIIA NSCLC patients...
Background Although antiretroviral therapy during pregnancy is associated with significant reductions in the risk of vertical transmission HIV, attainment this outcome highly treatment-experienced pregnant women might be complicated by lack active drugs available to assemble a potent regimen. The recent licensing and availability darunavir, etravirine raltegravir has broadened management options for patients. However, data on their safety efficacy preventing are limited. Methods A...
Los autores encuestaron una muestra de evacuados desplazados por el Huracán Gustav sobre su decisión incluir o no a las mascotas familiares en sus planes evacuación. datos fueron recolectados lo largo dos mayores rutas evacuación dentro del periodo 48 horas previo que huracán llegara tierra la región sur y costera Louisiana, al Interestatal 10. Datos códigos postales través encuestas demostraron los encuestados salían con mayor frecuencia regiones código postal Nueva Orleans, Houma,...
Purpose: Double protease inhibitor (PI) boosting is being explored as a new strategy in salvage antiretroviral (ARV) therapy. However, if negative drug interaction leads to decreased levels of either or both PIs, double PI could lead virologic response. A has been described between amprenavir (APV) and lopinavir/ritonavir (LPV/r). This observational cohort study assessed the impact addition APV ARV regimen, which also contains LPV/r, compared regimen containing LPV/r alone. Method: Patients...
e13586 Background: Real World Data (RWD) collected during routine medical practice can help in clinical trial design, planning and execution. In addition, it provide a compelling picture of safety products, account for all potential adverse events that be encountered practice. However, raw drug information about chemotherapy cancer care is not readily understandable the format collected. Analytical techniques need to applied extract regimen information, which includes drugs, dosage, number...
To explore medications and their administration patterns in real-world patients with breast cancer.A retrospective study was performed using TriNetX, a federated network of deidentified, Health Insurance Portability Accountability Act-compliant data from 21 health care organizations across North America. Patients diagnosed cancer between January 1, 2013, May 31, 2022, were included. We investigated rule-based unsupervised learning algorithm to extract patterns. group similar patterns, we...
<b>Introduction:</b> Oral anti-fibrotics have been shown to attenuate lung function decline in PPF however side-effects, often gastrointestinal (GI), are common. Nebulised pirfenidone achieves a 35-fold higher peak epithelial lining fluid concentration and 1/15th of the systemic exposure than standard dose oral pirfenidone, with less frequent side effects stabilisation FVC phase Ib study (West A, et al. Thorax 2023, accepted for publication). <b>Methods:</b> A total 28 patients non-IPF PPF,...
<b>Introduction:</b> AP01 is a novel formulation of inhaled pirfenidone with potentially improved efficacy and reduced toxicity compared to oral in Idiopathic Pulmonary Fibrosis (IPF). The serial change Quantitative Lung (ΔQLF) on thoracic High-Resolution Computed Tomography (HRCT) correlates changes FVC. Correlation longitudinal quality life (QOL) and ΔQLF less established. <b>Objective:</b> AP01-002 was Phase 1b trial comparing the safety tolerability 50mg once daily (od) 100mg twice...
Background: Frequently used drugs in our unit are only available through Health Canada’s Special Access Programme (SAP) or a compounding pharmacy. A tracking system was implemented to evaluate the turnaround time (TAT) and success rate of SAP applications for parasitic infections. Methods: We undertook retrospective review logs from 2013 2015 inclusive, with outcomes TAT initial application rates over time. Analyses were stratified by drug indication. Results: The mean TATs all indications...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Introduction Patients with family history of premature coronary artery disease (CAD) are at increased risk CAD events a younger age. Risk factor based approaches and clinical evaluation most commonly used to assess these individuals. However, it has been recently shown that up 50% individual presenting their first myocardial infarction (MI) were considered be “low risk” prior event. MI is often result plaque rupture preceded by progression subclinical atherosclerosis. Detection...