A5036820200- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Bioinformatics and Genomic Networks
- Clusterin in disease pathology
- Geriatric Care and Nursing Homes
- Parkinson's Disease Mechanisms and Treatments
- Inflammation biomarkers and pathways
- Neurological Disease Mechanisms and Treatments
- Renal and related cancers
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Endoplasmic Reticulum Stress and Disease
- Air Quality and Health Impacts
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Moyamoya disease diagnosis and treatment
- Vascular Malformations Diagnosis and Treatment
- Neurological Disorders and Treatments
- Frailty in Older Adults
- Genetics and Neurodevelopmental Disorders
- Health, Environment, Cognitive Aging
- Diabetes Treatment and Management
- Fibroblast Growth Factor Research
- Nerve injury and regeneration
- Mitochondrial Function and Pathology
- Respiratory and Cough-Related Research
Taipei Veterans General Hospital
2018-2025
National Yang Ming Chiao Tung University
2019-2025
Korea Institute of Brain Science
2023
Taipei Municipal YangMing Hospital
2023
National Taipei University
2019-2021
National Health Research Institutes
2021
National Yang Ming University Hospital
2020
National Taiwan University Hospital
2013
National Taipei University of Technology
2003
Plasma neurofilament light (NFL) has been proposed as a blood-based biomarker for neurodegeneration in Alzheimer's disease (AD) and parkinsonian disorders. However, the relationship between plasma NFL cognitive decline dementia due to Parkinson's (PD) remains be elucidated. In this research, 119 AD, 56 mild impairment (MCI), 26 non-demented PD (PDND), 23 (PDD) patients, well 59 cognitively healthy controls (HC) were recruited. Each subject underwent battery of neuropsychological testing....
STUDY QUESTIONWhat is the value of a new strategy for preimplantation genetic diagnosis (PGD) monogenic diseases: blastocyst biopsy, cryopreservation and thawed embryo transfer?
Abstract INTRODUCTION Plasma phosphorylated tau (p‐tau) biomarkers have improved Alzheimer's disease (AD) diagnosis, but data from diverse Asian populations are limited. This study evaluated plasma p‐tau217 and p‐tau181 levels in Korean Taiwanese populations. METHODS All participants ( n = 270) underwent amyloid positron emission tomography (PET) blood tests. p‐tau model‐derived probabilities of PET positivity (amyloid beta [Aβ]+) classified into low‐, intermediate‐, or high‐risk groups....
Mutations in the presenilin 1 gene (PSEN1) are well-known causes of early-onset familial Alzheimer's disease, but they can also present with atypical phenotypes such as pure spastic paraparesis. This study aims to investigate clinical and genetic features PSEN1 variants patients mainly manifested hereditary paraparesis (HSP)-like phenotypes. Mutational analysis was performed 242 unrelated Taiwanese clinically suspected HSP using a targeted resequencing panel covering entire coding regions...
To investigate the summative effects of vascular risk factors (VRFs) on progression Alzheimer disease (AD).Longitudinal follow-up cohort study.AD patients from two teaching hospitals in Taiwan with 3-year follow-ups.A total 330 AD a mean age 80.7 years, Mini-Mental State Examination (MMSE) score 18.7, and Clinical Dementia Rating Sum Boxes (CDRSB) 6.9.All completed clinically functional assessment neuropsychological test battery at baseline yearly follow-ups. The VRF burden was combined into...
Neuropsychiatric symptoms (NPS) could increase mortality risk in people with dementia due to Alzheimer's disease (AD). However, whether NPS affects mild cognitive impairment (MCI) and any specific syndrome of influences this are still unclear.In total, 984 participants AD, 338 MCI, 365 controls were enrolled. Over a mean 5-year follow-up, cause death data obtained from the Ministry Health Welfare Taiwan. assessed using Inventory Questionnaire (NPI-Q), psychosis, mood, frontal domain scores...
Abstract Background The Mild Behavioral Impairment Checklist (MBI‐C) was developed to assess neuropsychiatric symptoms (NPS) and identify mild behavioral impairment (MBI). This study validated the Taiwanese version of MBI‐C examined its association health‐related quality life (HR‐QoL). Methods We recruited 242 older individuals without dementia (129 amnestic cognitive impairment, 113 cognitively normal). Their family completed MBI‐C, Neuropsychiatric Inventory Questionnaire (NPI‐Q),...
Health-related quality of life (HRQoL) is an essential outcome parameter in geriatric research; however, the available evidence mixed regarding factors associated with HRQoL among people dementia. We aimed to identify that contribute dementia residential long-term care (LTC) institutions. randomly selected 299 1607 registered LTC institutions Taiwan. A cross-sectional survey was conducted between 2019 and 2020, including items on demographic characteristics, comorbidities, EuroQol-5...
Mutations in PSEN1, PSEN2, or APP genes are known to be causative for autosomal dominant Alzheimer's disease (ADAD). While more than 400 mutations were reported worldwide, predominantly over 40 have been Han Chinese and associated with earlier onset affected family members. Between 2002 2018, 77 patients the neurological clinic of Taipei Veterans General Hospital a history suggestive ADAD referred mutational analysis. We retrospectively collected demographics, initial symptoms, features...
Whole exome sequencing (WES) has been used to detect rare causative variants in neurological diseases. However, the efficacy of WES genetic diagnosis clinically heterogeneous familial stroke remains inconclusive. We prospectively searched for disease-causing unrelated probands with defined by candidate gene/hotspot screening and/or WES, depending on subtypes and neuroimaging features at a referral center. The clinical significance each variant was determined according American College...
Background: Brain-derived neurotrophic factor (BDNF) has been implicated in the pathophysiology of Alzheimer’s disease (AD), and decreased peripheral levels this protein are associated with an increased risk developing disease. This study focuses on whether serum BDNF could be used as a predictor AD progression. Methods: In longitudinal observational study, we recruited cognition normal participants (N = 98) 442) from Clinic at Taipei Veterans General Hospital. We conducted mini-mental...
Genetic background has been considered one of the important contributors to rate cognitive decline among patients with Alzheimerâs disease (AD). We conducted a 4-year longitudinal follow-up study, recruited 255 AD and 44 mild impairment (MCI) patients, used data-driven trajectory analysis examine influence selected risk genes on age for in Han Chinese population. Genotyping single-nucleotide polymorphisms APOE, ABCA7, SORL1, BIN1, GAB2, CD33 was conducted, Bayesian hierarchical model...
To determine the effect of blood phosphorylated tau 181 (pTau181) on mental decline rate patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI)
Triggering receptor expressed on myeloid cells 2 (TREM2) is upregulated in activated microglia and may be related to cognitive decline patients with Alzheimer’s disease (AD). There conflicting evidence regarding the association of peripheral TREM2 mRNA expression/soluble (the extracellular domain TREM2) function/neuroinflammation AD. Herein, we studied alt expression their performance subjects mild dementia due AD healthy controls. In a subgroup AD, magnetic resonance spectroscopy was used...
Abstract Background There is a strong genetic component to Alzheimer’s disease (AD), as evidenced in genome‐wide association studies (GWASs) that have identified new variants associated with the disease. This particularly true for apolipoprotein E (APOE) gene and its neighboring genes on chromosome 19q13.3. In addition, air pollution was linked aggravating development of AD. A significant gap remains understanding gene‐environment interactions influencing AD susceptibility. The purpose this...
Abstract Background Plasma phosphorated tau 181 (p‐tau181) was found to change in concordance with amyloid PET and well before PET, suggesting that the secretion of p‐tau181 may represent a physiologic reaction β‐amyloid plaques. Our study aimed evaluate relationship between plasma whether predicts amnestic MCI AD conversion. Method We included 98 participants (43 demented 55 nondemented) who underwent florbetaben scan. Amyloid interpreted by visual assessment based on brain plaque load...
On the various algorithms proposed for longest common subsequence (LCS) problem, systolic are fastest. A new algorithm that improves on previous is presented. Compared with algorithms, it requires simpler operations as well fewer I/O ports and data transfers between neighboring processing elements. The steps when recovering an LCS.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Abstract Background Triggering receptor expressed on myeloid cells 2 (TREM2) is upregulated in activated microglia and may be related to cognitive decline patients with Alzheimer’s disease (AD). There conflicting evidence regarding the association of peripheral levels TREM2 mRNA expression soluble (the extracellular domain TREM2) function AD. The correlation between neuroinflammation unclear. Methods We recruited subjects mild dementia due AD (clinical rating = 0.5 or 1) healthy controls....