A5101521578- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Tissue Engineering and Regenerative Medicine
- Chronic Disease Management Strategies
- Polymer Surface Interaction Studies
- Peripheral Artery Disease Management
- Corneal surgery and disorders
- Cerebrovascular and Carotid Artery Diseases
- Nutrition and Health in Aging
- Phytoestrogen effects and research
- Magnesium in Health and Disease
- Computational Drug Discovery Methods
- Intestinal Malrotation and Obstruction Disorders
- Pancreatitis Pathology and Treatment
- Pharmacogenetics and Drug Metabolism
- Pharmacovigilance and Adverse Drug Reactions
- Rheumatoid Arthritis Research and Therapies
- Healthcare Systems and Reforms
- Medication Adherence and Compliance
- Potassium and Related Disorders
- Silk-based biomaterials and applications
- Estrogen and related hormone effects
- Acute Kidney Injury Research
- Body Contouring and Surgery
- Analytical Chemistry and Sensors
Tzu Chi University
2015-2024
Taipei Tzu Chi Hospital
2015-2024
National Chung Hsing University
2021-2024
University of Glasgow
2024
Buddhist Tzu Chi Medical Foundation
2020-2023
Taichung Hospital
2019-2023
National Defense Medical Center
2007-2021
Tri-Service General Hospital
2007-2021
National Yang Ming Chiao Tung University
2015-2021
Taichung Veterans General Hospital
2018-2021
Toll-like receptors (TLRs) are vital components of the innate immune system, serving as first line defense against pathogens by recognizing a wide array molecular patterns. This review summarizes critical roles TLRs in surveillance and disease pathogenesis, focusing on their structure, signaling pathways, implications various disorders. We discuss intricacies TLRs, including ligand specificity, cascades, functional consequences activation. The involvement infectious diseases, autoimmunity,...
The molecular basis for spontaneous resolution of acute gouty arthritis (GA) remains unclear. hypothesis that extracellular and intracellular mechanisms play roles in resolving GA was tested.Synovial fluid (SF) levels transforming growth factor β1 (TGFβ1), interleukin 1 (IL-1) receptor antagonist (IL-1ra), IL-10 soluble tumour necrosis (TNF) I (sTNFRI) II (sTNFRII) were measured by ELISA patients with osteoarthritis (OA). Monosodium urate (MSU) crystal-stimulated RAW264.7 mouse macrophages...
Sarcopenia is frequently encountered in patients undergoing peritoneal dialysis (PD). We evaluated and compared the diagnostic performance of a strength, assistance walking, rise from chair, climb stairs, falls (SARC-F) questionnaire, SARC-F combined with calf circumference (SARC-CalF), (CC) for screening sarcopenia among PD. measured appendicular skeletal muscle mass, using multifrequency bioimpedance spectroscopy device, handgrip 6-m gait speed. SARC-F, SARC-CalF, CC were obtained all...
In this study we aimed to identify the predictors of drug survival for biologic and targeted synthetic DMARDs (bDMARDs tsDMARDs) among patients with rheumatoid arthritis (RA) in a real-world setting. Data from RA receiving bDMARDs tsDMARDs between 2007 2019 were extracted Taiwan Rheumatology Association Clinical Electronic Registry (TRACER). Patients categorized into tumor necrosis factor-alpha (TNF-α) inhibitors, non-TNF-α tofacitinib groups. The primary outcome was 3-year retention causes...
Corneal keratocytes have been reported to be able form spheroids that can preserve their phenotypes after being seeded back onto tissue culture plate in specific media. In this study, we found could also on a bioengineered material, chitosan-coated surface, with 10% horse serum and Dulbecco's modified Eagle's medium. Under scanning electron microscopy observation, the cells were adhere each other tightly, cellular boundary not distinguished. They return dendritic (keratocyte) morphology...
Background The CHADS2 and CHA2DS2 scores are usually applied for stroke prediction in atrial fibrillation patients, the Charlson comorbidity index (CCI) is a commonly used scale assessing morbidity. role mortality with score system hemodialysis not clear comparisons lacking. We aimed at evaluating CHADS2, CHA2DS2, CCI to predict incident patients. Methods Using data from Nation Health Insurance of Taiwan (NHIRD) 1 January 2005 31 December 2009, individuals ≧20 y/o who began identified by...
Summary Myelin sheaths comprise compacted layers of oligodendroglial membrane wrapped spirally around axons. Each sheath, if imagined unwrapped, has a cytoplasm-filled space at its perimeter, linking it to the oligodendrocyte soma via short process. By electron microscopy (EM), this space, which we term ‘ myelinic channel system ’ contains microtubules and membranous organelles, but whether these are remnants development or serve function is unknown. Performing live imaging myelinating...
Contrast is widely used in invasive image examinations such as computed tomography (CT) and angiography; however, the risk of contrast-induced nephropathy (CIN) high. The aim this study was to investigate protective effect resveratrol a rat model CIN. Sprague-Dawley rats were divided into four groups: control group (0.9% saline infusion only); (RSV, resveratrol, 30 mg/kg); contrast media (CIN); + (RCIN, mg/kg 60 min before CIN). CIN induced via an intravenous injection single dose...
This study explores the possible association between risk of ischemic stroke and conjugated equine estrogen (CEE) use in women who are over 55 years old have diabetes. Data from National Health Insurance system Taiwan were used to identify 428 with diabetes CEE (0.625 mg daily) 2003 2009. For comparison, 21026 same cohort did not as a control group, excluding patients previous at baseline. The propensity score method was 1:3 ratio for matched (n = 1284). Covariates score-matching included...
Abstract Medication adherence plays an important role in disease management, especially for diabetes. The aim of this study was to examine the impacts demographic characteristics on medication nonadherence and both health status medical expenses diabetic patients Taiwan. A total 1 million diabetes mellitus were randomly selected from National Health Insurance Research Database between January 1, 2000 December 31, 2004. All records with missing values those participants under 18 years age...
Objective Sarcopenia is highly prevalent in patients undergoing peritoneal dialysis (PD), contributing to adverse clinical outcomes. Animal models suggest that parathyroid hormone (PTH) induces muscle wasting through adipose tissue browning. However, the relationship between PTH dysregulation and sarcopenia PD population remains unclear. Thus, we aimed explore association serum intact levels patients. Methods We conducted a cross-sectional analysis using data from Tzu-Chi cohort, comprising...
To clarify the nature of power Doppler (PD) signals in rheumatoid synovium and to establish connection between PD active inflammation using synovial histopathology. Ten adult patients (median age 57.0 years, 9 women one man) with arthritis (RA) were enrolled received ultrasound (US) examinations. US-guided biopsies core needle performed 7 knees, 2 wrists elbow. Each patient had joint biopsied. In total, 11 specimens obtained for hematoxylin eosin staining histopathologic The US examinations...
Introduction: Traditional Chinese Medicine (TCM) has a broad application in healthcare, with Danshen being notable herb used Eastern medicine for cancer treatment. This study aims to explore the relationship between use and cardiovascular risks among bladder patients. Methods: Patients were selected based on confirmed diagnosis of specific inclusion exclusion criteria control certain comorbidities treatments. Utilizing Taiwan's National Health Insurance data from 2003 2013, this...
We apply a heterogeneous graph convolution network (GCN) combined with multi-layer perceptron (MLP) denoted by GCNMLP to explore the potential side effects of drugs. Here SIDER, OFFSIDERS, and FAERS are used as datasets. integrate drug information similar characteristics from datasets known drugs effect networks. The networks inferring relationship between related effects. This novel in silico method will shorten time spent uncovering unseen within routine prescriptions while highlighting...
N-terminal pro b-type natriuretic peptide (NT-proBNP) was considered a prognostic factor for mortality in hemodialysis patients previous studies. However, NT-proBNP has not been fully explored terms of predicting other clinical outcomes patients. This study aimed to investigate if could predict emergency department (ED) visits, hospitalization, admission intensive-care unit (ICU), and cardiovascular incidents Serum indicators were collected 232 Patients followed up three years or until...