A5016298087- Air Quality and Health Impacts
- Cardiac electrophysiology and arrhythmias
- Heavy Metal Exposure and Toxicity
- Cardiac Arrhythmias and Treatments
- Effects and risks of endocrine disrupting chemicals
- Atrial Fibrillation Management and Outcomes
- Carcinogens and Genotoxicity Assessment
- Electrochemical sensors and biosensors
- Toxic Organic Pollutants Impact
- Ion channel regulation and function
- Electrochemical Analysis and Applications
- Per- and polyfluoroalkyl substances research
- Nanoparticles: synthesis and applications
- Cardiovascular Function and Risk Factors
- Advanced Chemical Sensor Technologies
- Metabolomics and Mass Spectrometry Studies
- Genomics, phytochemicals, and oxidative stress
- Cardiac Ischemia and Reperfusion
- Cardiac pacing and defibrillation studies
- Emergency and Acute Care Studies
- Analytical Chemistry and Chromatography
- Microfluidic and Capillary Electrophoresis Applications
- Cardiac Imaging and Diagnostics
- Planarian Biology and Electrostimulation
- Pharmacogenetics and Drug Metabolism
Chang Gung University
2002-2024
Fu Jen Catholic University
2015-2024
Chang Gung Memorial Hospital
2014-2024
Chang Gung University of Science and Technology
2009-2023
National Taiwan University Hospital
2023
University of Kang Ning
2023
Memorial Hospital of South Bend
2020-2022
Ministry of Health and Welfare
2022
Bridge University
2021
Taipei Veterans General Hospital
2019-2020
The aim of this study was to identify the health hazards and possible exposure surveillance markers workers exposed nanoparticles during manufacturing application in comparison a group unexposed workers. For longitudinal study, we recruited 158 nanomaterial-handling 104 non-exposed from 14 plants Taiwan (baseline). Among them, 124 77 were monitored 6 months later. We investigated pulmonary cardiovascular disease markers, inflammation oxidative stress antioxidant enzymes genotoxicity markers....
A novel sorbent Cu-S metal-organic framework (MOF) microrods was prepared for dispersive solid-phase extraction via microwave synthesis and used to determine 12 fluoroquinolones (FQs) in honey samples employing ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The best efficiency achieved by optimizing sample pH, quantity, eluent type/volume, elution time. proposed MOF exhibits advantages such as rapid time (20 min) outstanding adsorption ability toward...
Beta-agonists are potent bronchodilators approved for the treatment of asthma and tocolysis. However, they have been extensively misused as feed additives in veterinary field to improve efficiency. The concern over their potential hazard health has come fore again. In this study, a novel vinylene-based covalent organic framework (V-COF-1) with two-dimensional structure was developed. shows good tolerance variety mediums, which can be attributed low polarity linkage. high specific surface...
Abstract Phthalate has been used worldwide in various products for years. Little is known about the association between phthalate exposure and biomarkers of oxidative stress adolescents young adults. Among 886 subjects recruited from a population-based cohort during 2006 to 2008, 751 (12–30 years) with complete metabolites oxidation measurement were enrolled this study. Nine urine metabolites, 8-hydroxydeoxyguanosine (8-OHdG), 8-iso prostaglandin F2α (8-isoPGF2α) measured assess DNA lipid,...
Background Compared with left atrial (LA) dimension, LA emptying fraction (LAEF) has received less emphasis as a predictor of fibrillation (AF) recurrence after radiofrequency catheter ablation (RFCA). In addition, patients experiencing post-RFCA AF may respond to previously ineffective antiarrhythmic drugs (AADs). Classifying these into third RFCA outcome category is recommended. Objective To identify predictors classified three categories, and build proportional odds logistic regression...
The main objective of this study was to evaluate the potential genetic effects SEPT14 on male infertility through sequencing coding region. To address research gap, 254 men with sperm abnormalities and 116 normozoospermic were recruited, whole-coding regions sequenced. Two heterozygous mutations, p.Ala123Thr (3/254 vs. 0/116) p.Ile333Thr 0/116), identified in these cases. A high percentage defective heads found mutated SEPT14. Both mutations are highly evolutionarily conserved among...
Abstract Background Although no human illness to date is confirmed be attributed engineered nanoparticles, occupational epidemiological studies are needed verify the health effects of nanoparticles. This study used a repeated measures design explore potential adverse workers handling nanomaterials. Methods Study population was 206 nanomaterial-handling and 108 unexposed controls, who were recruited from 14 nanotechnology plants. They followed up less than two times in four years. A...
Approximately 10%-15% of couples worldwide are infertile, and male factors account for approximately half these cases. Teratozoospermia is a major cause infertility. Although various mutations have been identified in teratozoospermia, can vary among ethnic groups. In this study, we performed whole-exome sequencing to identify genetic changes potentially causative teratozoospermia. Out seven genes identified, one, ATP/GTP Binding Protein 1 (AGTPBP1), was characterized, three missense were two...
Abstract Epidemiological studies have demonstrated that cooking oil fumes (COF) are an environmental risk factor for the development of lung adenocarcinoma among nonsmoking females in Taiwan. Aside from polycyclic aromatic hydrocarbons, aldehydes, especially trans, trans ‐2,4‐decadienal ( tt ‐DDE) found to be abundant COF. Although there is indication ‐DDE induces DNA damage, precise role induction damage cells still not clear. When we assessed breaks with Comet assay, induced by 1 μM human...
Traditional Chinese herbal medicine has long enjoyed the reputation of world's most advanced system natural medicine. Pinellia ternata is one commonly used herbs in traditional medical science. In this study, five representative ingredients guanosine, methionine, glycine, 3,4-dihydroxybenzaldehyde, and homogentisic acid, were assayed using simple derivatization procedures. Under optimized experimental condition, analytes rapidly separated detected microchip electrophoresis, affording...