A5081666408- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- CRISPR and Genetic Engineering
- Identification and Quantification in Food
- RNA Interference and Gene Delivery
- Retinal Imaging and Analysis
- Electrocatalysts for Energy Conversion
- Fungal Biology and Applications
- Graphene research and applications
- CAR-T cell therapy research
- Virus-based gene therapy research
- Bacteriophages and microbial interactions
- Proteins in Food Systems
- Gut microbiota and health
- DNA and Nucleic Acid Chemistry
- Medicinal Plants and Bioactive Compounds
- Plant Pathogens and Fungal Diseases
- Single-cell and spatial transcriptomics
- Luminescence and Fluorescent Materials
- Bioinformatics and Genomic Networks
- Algal biology and biofuel production
- Catalysis and Hydrodesulfurization Studies
- Catalysis for Biomass Conversion
- Fullerene Chemistry and Applications
- Synthesis and Properties of Aromatic Compounds
Qingdao University
2025
University College London
2012-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Beijing Institute of Technology
2009-2024
Ocean University of China
2018-2024
Great Ormond Street Hospital
2024
Zhejiang Institute of Special Equipment Inspection
2021-2024
Fuzhou University
2017-2023
Zunyi Medical University
2020-2023
Wuhan National Laboratory for Optoelectronics
2023
A branched ZnO-CdS double-shell NW array on the surface of a carbon fiber (CF/ZnO-CdS) was successfully synthesized via facile two-step hydrothermal method. Based single CF/ZnO-CdS wire polymer substrate, flexible photodetector fabricated, which exhibited ultrahigh photon responsivity under illuminations blue light (1.11 × 10(5) A/W, 8.99 10(-8) W/cm(2), 480 nm), green (3.83 10(4) 4.48 548 and UV (1.94 1.59 372 respectively. The this broadband sensor enhanced further by as much 60% when...
In this work, we propose a unique reaction mechanism that the Fe site OOH serves as auxiliary to accelerate formation of Co active species, hence accelerating rate-determining step OER.
The synthesis scheme for the formation pathway of monometallic and bimetallic nanoparticles supported on hydrochar derived from lignin-rich precursory biomass.
The CRISPR/Cas12a (cpf1) system was reported to indiscriminately cleave single-stranded DNA after binding with target strands. This usually required the strands contain protospacer-adjacent motif (PAM) sequence of TTTN. Herein, we found Cas12a can also recognize another PAM UUUN resulting in activation its ssDNA collateral cleavage effect. To make this finding useful, by combining LAMP, first realized for directly visualized detection at single-copy level. By treating UDG enzyme, made free...
Vibrio parahaemolyticus (V. parahaemolyticus), which may cause gastrointestinal disorders in humans, is a pathogen commonly found seafood. There are many methods for detecting V. parahaemolyticus, yet they have some shortcomings, such as high cost, labor-intensiveness, and complicated operation, impractical resource-limited settings. Herein, we present sequence-specific, label-free, colorimetric method visual detection of parahaemolyticus. This utilizes CRISPR/Cas12a to specifically...
Using fluorescently labeled DNA oligonucleotides and nanomaterials for developing biosensors has been extensively reported gold nanoparticles (AuNPs) graphene oxide (GO) among others. These materials have vastly different affinities mechanisms interacting with DNA, their analytical performance is likely to be different. In this work, we used several sequences and, respectively, adsorbed them on AuNPs GO quench fluorescence. Different from previous KCN fully dissolve the calculate percentage...
Alcoholic liver injury is mainly caused by excessive alcohol consumption and has become a global public health problem threatening human health. It well known that Ganoderma lucidum possesses various excellent beneficial effects on function lipid metabolism. The purpose of this study was to evaluate the underlying protective effect action mechanism ganoderic acids-rich G. ethanol extract (GLE) alcohol-induced in mice with intake. Results showed oral administration GLE could obviously inhibit...
Herein, we have developed a simple and effective strategy for in situ preparation of nanoscale zerovalent iron (NZVI) supported on porous carbon (PC) using renewable hydrochar as the precursor. Physicochemical properties resultant NZVI/PC composites were characterized by XRD, SEM-EDS, TEM, BET, effectiveness these was evaluated remediation PCB-contaminated water. Results showed that ions uniformly dispersed within matrix serve an activation agent during subsequent pyrolysis process. The is...
On-site monitoring the plantation of genetically modified (GM) crops is critical importance in agriculture industry throughout world. In this paper, a simple, visual and instrument-free method for instant on-site detection GTS 40-3-2 soybean has been developed. It based on body-heat recombinase polymerase amplification (RPA) followed with naked-eye via fluorescent DNA dye. Combining extremely simplified sample preparation, whole process can be accomplished within 10 min results photographed...
This study aimed to investigate the protective effects of ganoderic acids (GA) from Ganoderma lucidum against liver injury and intestinal microbial disorder in mice with excessive alcohol intake. Results showed GA supplement significantly inhibited abnormal elevation index, serum lipid parameters, aspartate aminotransferase alanine exposed intake, also protected accumulation pathological changes. Alcohol-induced oxidative stress was ameliorated by intervention through reducing levels maleic...
The ideal interface design between the metal and substrate is crucial in determining overall performance of alkyne semihydrogenation reaction. Single-atom alloys (SAAs) with isolated dispersed active centers are media for study reaction effects. Herein, a charge-asymmetry "armor" SAA (named Pd1Fe SAA@PC), which consists alloy core semiconducting P-doped C (PC) shell, rationally designed as an catalyst selective hydrogenation alkynes high efficiency. Multiple spectroscopic analyses density...
Single T4-DNA molecules were confined in rectangular-shaped channels with a depth of 300nm and width the range 150–300nm casted poly(dimethylsiloxane) nanofluidic chip. The extensions DNA measured fluorescence microscopy as function ionic strength composition buffer well intercalation level by YOYO-1 dye. data interpreted scaling theory for wormlike polymer good solvent, including effects confinement, charge, self-avoidance. It was found that elongation decreasing can be terms an increase...
Recombination activating gene 2 (RAG2) deficiency results in severe combined immunodeficiency (SCID) with complete lack of T and B lymphocytes. Initial gammaretroviral therapy trials for other types SCID proved effective, but also revealed the necessity safe vector design. We report development lentiviral vectors spleen focus forming virus (SF) promoter driving codon-optimized human RAG2 (RAG2co), which improved phenotype amelioration compared to native Rag2(-/-) mice. With RAG2co...