A5053968614- Innovations in Medical Education
- Medical Education and Admissions
- Primary Care and Health Outcomes
- Inflammatory Bowel Disease
- Microscopic Colitis
- Clinical Reasoning and Diagnostic Skills
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Gastrointestinal disorders and treatments
- Retinal Diseases and Treatments
- Effects of Radiation Exposure
- Biomedical and Engineering Education
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- Gastroesophageal reflux and treatments
- Nursing Roles and Practices
- Helicobacter pylori-related gastroenterology studies
- Healthcare cost, quality, practices
- Pancreatitis Pathology and Treatment
- Health and Medical Research Impacts
- Surgical Simulation and Training
- Child and Adolescent Health
- Gastrointestinal Bleeding Diagnosis and Treatment
- Esophageal and GI Pathology
- Global Health Workforce Issues
University Hospitals Birmingham NHS Foundation Trust
2015-2024
East Sussex Healthcare NHS Trust
2023
Cambridge University Hospitals NHS Foundation Trust
2023
Uniformed Services University of the Health Sciences
2018-2022
Queen Elizabeth Hospital Birmingham
2019-2022
University of Birmingham
2017-2022
West Virginia University
2022
Albert Einstein College of Medicine
2017-2021
West Virginia University Hospitals
2021
Memorial Hospital
2021
Defects in cilia-centrosomal genes cause pleiotropic clinical phenotypes, collectively called ciliopathies. Cilia biogenesis is initiated by interaction of positive and negative regulators. The centriolar coiled coil protein CP110 caps the distal end mother centriole shown to act as a suppressor control timing ciliogenesis. Here we demonstrate that promotes cilia formation vivo unlike findings cultured cells. Cp110−/− mice die shortly after birth because organogenesis defects Shh signaling...
The threat of a nuclear attack has increased in recent years highlighting the benefit developing additional therapies for treatment victims suffering from Acute Radiation Syndrome (ARS). In this work, we evaluated impact PEGylated thrombopoietin mimetic peptide, JNJ-26366821, on mortality and hematopoietic effects associated with ARS mice exposed to lethal doses total body irradiation (TBI). JNJ-26366821 was efficacious as mitigator thrombocytopenia both CD2F1 C57BL/6 TBI cobalt-60 gamma-ray...
Background The principal aim of malignant pleural effusion (MPE) management is to improve health-related quality life (HRQoL) and symptoms. Methods In this open-label randomised controlled trial, patients with symptomatic MPE were randomly assigned either indwelling catheter (IPC) insertion the option talc pleurodesis or chest drain pleurodesis. primary end-point was global health status, measured 30-item European Organisation for Research Treatment Cancer Quality Life Core Questionnaire...
Abstract Background We have earlier shown that protein levels of vascular endothelial growth factor-A (VEGF-A) and chemokine ligand-2 (CCL2) were elevated in Indian amyotrophic lateral sclerosis (ALS) patients. Here, we report the mRNA VEGF-A CCL2 ALS patients since they display extended survival after disease onset. Methods measured peripheral blood mononuclear cells (PBMCs) 50 sporadic using Real Time Polymerase Chain Reaction (PCR) compared with normal controls (n = 50). Their adjusted...
Gamma-tocotrienol (GT3), a naturally occurring vitamin E isomer, promising radioprotector, has been shown to protect mice against radiation-induced hematopoietic and gastrointestinal injuries. We analyzed changes in protein expression profiles of spleen tissue after GT3 treatment exposed gamma radiation gain insights into the molecular mechanism radioprotective efficacy. Male CD2F1 mice, 12-to-14 weeks old, were treated with either vehicle or at 24 h prior 7 Gy total-body irradiation....
Mobile devices are increasingly being used by undergraduate students to access online information in the problem-based learning (PBL) process, initially self-directed phase, and more recently within face-to-face tutorials. This qualitative study across three health professional programs semi-structured interviews investigate facilitators' students' perceptions of mobile device usage PBL Transcribed were analyzed thematically, drawing on principles grounded theory. Implications for future...
Mitochondria are linked with various radiation responses, including mitophagy, genomic instability, apoptosis, and the bystander effect. play an important role in preserving cellular homeostasis during stress dysfunction mitochondrial contributes to aging, carcinogenesis neurologic diseases. In this study, we have investigated degeneration autophagy hippocampal region of brains from mice administered BBT-059, a long-acting interleukin-11 analog, or its formulation buffer 24 h prior...
The one‐minute preceptor (OMP) is a time‐efficient, learner‐centered teaching method used in busy ambulatory care setting. This project evaluated the effects of training experienced anatomy teachers use OMP gross laboratory on students' perceived learning. Second‐year medical students from five‐year, undergraduate‐entry, system‐ and problem‐based program were divided randomly into two groups 76 each. took part same session different dates, supervised by (both with over 25 years experience)....
Age related macular degeneration (AMD) is one of the major retinal degenerative disease ageing whose complex genetic basis remains undeciphered. The involvement various other factors like mitochondrial genes, cytoskeletal proteins and role epigenetics has been described in this review. Several population based AMD studies have carried out worldwide. Despite increased publication reports, clinical translation still eludes davastating disease. We suggest models to address roadblocks hoping...
Granulomatous pneumonitis is a well-recognised complication of intravesical BCG therapy. The mechanism sometimes thought to be ‘hypersensitivity’ rather than infection as in most cases mycobacteria are not cultured. Despite this it usually treated with antituberculous chemotherapy or without corticosteroid. We describe case bladder cancer followed by febrile illness and malaise lasting for months the development miliary pulmonary shadowing, which markedly improved around 1 year any...
Acute exposure to ionizing radiation leads Hematopoietic Radiation Syndrome (H-ARS). To understand the inter-strain cellular and molecular mechanisms of sensitivity, adult males two strains minipig, one with higher radiosensitivity, Gottingen minipig (GMP), another strain comparatively lower Sinclair (SMP), were exposed total body irradiation (TBI). Since Insulin-like Growth Factor-1 (IGF-1) signaling is associated sensitivity regulation cardiovascular homeostasis, we investigated link...
Radiation injury will result in multiorgan dysfuntion leading to failure. In addition many factors such as radiation dose, dose rate, the severity of also depend on organ systems which are exposed. Here, we report protective property gamma tocotrienol (GT3) total well partial body irradiation (PBI) model C3H/HeN male mice. We have carried out PBI by targeting thoracic region (lung-PBI) using Small Animal Research Platform, an X-ray irradiator with capabilities image guided a variable...
Age related macular degeneration (AMD) is the most common cause of visual impairment and characterized by drusen formation, geographic atrophy gradual loss vision. It a frightening disease that destroys macula, central part retina, severely regimenting person's normal sight. The utility mouse models with features AMD along its recently reported association complement factor H-gene, TLR 4 genes strongly suggest importance inflammatory mediators in pathogenesis this disease. Current treatment...
Background and Aim Dye‐based chromoendoscopy ( DCE ) with targeted biopsies is recommended for inflammatory bowel disease IBD surveillance. However, has not yet been widely adopted into clinical practice. We evaluated quality indicators in surveillance following introduction of structured changes service delivery. Methods In August 2016, we introduced a number to practice our endoscopy unit. These included training using interactive videos/images module, as standard by foot‐pedal operated...