A5023759255- Single-cell and spatial transcriptomics
- Hydrocarbon exploration and reservoir analysis
- Genomics and Chromatin Dynamics
- CRISPR and Genetic Engineering
- Hydraulic Fracturing and Reservoir Analysis
- Cancer, Lipids, and Metabolism
- Petroleum Processing and Analysis
- Ferroptosis and cancer prognosis
- Catalytic Processes in Materials Science
- Statistical Distribution Estimation and Applications
- Virus-based gene therapy research
- Epigenetics and DNA Methylation
- Mathematical functions and polynomials
- Structural Health Monitoring Techniques
- Gene expression and cancer classification
- Advanced Fluorescence Microscopy Techniques
- Sparse and Compressive Sensing Techniques
- RNA Research and Splicing
- Statistical Methods and Inference
- Cancer, Hypoxia, and Metabolism
- Catalysts for Methane Reforming
- Advanced Optical Imaging Technologies
- Analytic Number Theory Research
- Soil and Unsaturated Flow
- Financial Crisis of the 21st Century
Xinjiang Academy of Agricultural Sciences
2025
Shandong University of Traditional Chinese Medicine
2022-2025
China Academy of Chinese Medical Sciences
2025
Chinese Academy of Sciences
2019-2024
University of Chinese Academy of Sciences
2019-2024
Qujing Normal University
2024
Shaanxi Normal University
2024
Xi'an Medical University
2024
Jilin Agricultural University
2022-2024
Peking Union Medical College Hospital
2024
Insufficient or disrupted sleep increases the risk of cardiovascular disease, including atherosclerosis. However, we know little about molecular mechanisms by which modulates atherogenesis. This study aimed to explore potential role circulating exosomes in endothelial inflammation and atherogenesis under deprivation status involved.Circulating were isolated from plasma volunteers with without mice subjected 12-week control littermates. miRNA array was performed determine changes expression...
Atractylodes chinensis (DC.) Koidz. is an aromatic and medicinal plant in East Asia. The primary bioactive compounds this species are sesquiterpenes, particularly β-eudesmol, hinesol, atractylon. Cultivation techniques require improvement to meet the demands of species. In study, gas chromatography–mass spectrometry analysis A. germplasm showed its essential oil contained various including a high relative ratio β-eudesmol. Full-length transcriptome profiling revealed 26 genes related...
Formononetin (FM), an isoflavone with a range of anti-cancer activities, has not been fully elucidated regarding its anti-hepatocellular carcinoma (HCC) mechanisms. Therefore, this study aims to explore the underlying mechanisms FM using comprehensive pharmacology model based on computational technologies and omics technology. A network approach was applied detect components targets. mathematical formula used evaluate contribution index (CI). Bioinformatics analysis analyze clinical data...
P38α has been identified as a key target for drug design to treat wide range of diseases. In this study, multiple independent Gaussian accelerated molecular dynamics (GaMD) simulations, deep learning (DL), and the mechanics generalized Born surface area (MM-GBSA) method were used investigate binding mechanism inhibitors (SB2, SK8, BMU) DFG-in DFG-out clarify effect conformational differences in on inhibitor binding. GaMD trajectory-based DL effectively important functional domains, such...
Topologically associating domains (TAD) are a key structure of the 3D mammalian genomes. However, prevalence and dynamics TAD-like in single cells remain elusive. Here we develop new algorithm, named deTOKI, to decode with single-cell Hi-C data. By non-negative matrix factorization, deTOKI seeks regions that insulate genome into blocks minimal chance clustering. outperforms competing tools reliably identifies cells. Finally, find not only prevalent, but also subject tight regulation
Dipole-spread function (DSF) engineering reshapes the images of a microscope to maximize sensitivity measuring 3D orientations dipole-like emitters. However, severe Poisson shot noise, overlapping images, and simultaneously fitting high-dimensional information-both orientation position-greatly complicates image analysis in single-molecule orientation-localization microscopy (SMOLM). Here, we report deep-learning based estimator, termed Deep-SMOLM, that achieves superior 2D position...
In situ heat injection is a suitable technique for extracting shale oil from reservoirs with high organic matter content but insufficient thermal maturation. To optimize the stimulation process and to avoid unnecessary energy consumption, understanding effects of parameters crucial. This research employs self-developed simulator build 2D numerical model in conversion kerogen electric heaters. A benchmark first established determine on crude production decomposition. Subsequently, this study...
Oil shale, as a vast potential resource, is considered an important alternative energy source, and its effective development economic utilization are of significant importance in alleviating the contradiction between supply demand. Presently, situ conversion technology for oil shale has gained global attention, with numerous extraction methods undergoing active research development. One these based on hydration reaction calcium-oxide-based composite material (CaO-CM). This approach harnesses...
Nanomanipulation under scanning electron microscopy (SEM) enables direct interactions of a tool with sample. We recently developed nanomanipulation technique for the extraction and identification DNA contained within sub-nuclear locations single cell nucleus. In sub-cellular structures, key step is to identify targets interest through correlating fluorescence SEM images. The task must be conducted low accelerating voltages resulting in imaging resolutions. This imposed by necessity...
Cardiac magnetic resonance (CMR) is a diagnostic tool that provides precise and reproducible information about cardiac structure, function, tissue characterization, aiding in the monitoring of chemotherapy response patients with light-chain amyloidosis (AL-CA). This study aimed to evaluate feasibility CMR responses AL-CA.
Air pollution significantly impacts lung cancer progression, but there is a lack of comprehensive molecular characterization clinical samples associated with air pollution. Here, we performed proteogenomic analysis adenocarcinoma (LUAD) in 169 female never-smokers from the Xuanwei area (XWLC cohort), where coal smoke primary contributor to high incidence. Genomic mutation revealed XWLC as distinct subtype LUAD separate cases smoking or endogenous factors. Mutational signature suggested that...
All-optical clock recovery from 40 Gbit/s non-return-to-zero (NRZ) data has been experimentally demonstrated by using a fibre-pigtailed Fabry–Perot filter and self-pulsing two-section gain-coupled distributed feedback laser. The recovered measured root-mean-square (RMS) timing jitter of 1.2 ps. Error-free performance achieved in back-to-back bit error ratio (BER) tests the optically clock.
AbstractIn this paper, we study the existence and optimal control of quasi-hemivariational inequalities by a method different from one based on Minty's technique. We use an approach similar to Galerkin minimax inequality formulation associated with Brézis pseudomonotonicity notion multi-valued operators, implicit Browder–Tikhonov regularization fixed point theorem. This leads us avoid any kind monotonicity-type conditions used in recent papers obtain convexity solution set variational...