A5033554769- Trauma and Emergency Care Studies
- Gun Ownership and Violence Research
- Suicide and Self-Harm Studies
- Emergency and Acute Care Studies
- Cardiac Arrest and Resuscitation
- Injury Epidemiology and Prevention
- Trauma Management and Diagnosis
- Abdominal Trauma and Injuries
- Abdominal Surgery and Complications
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Appendicitis Diagnosis and Management
- Pelvic and Acetabular Injuries
- Traumatic Ocular and Foreign Body Injuries
- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Procedures and Complications
- Autopsy Techniques and Outcomes
- Urologic and reproductive health conditions
- Posttraumatic Stress Disorder Research
- Neurosurgical Procedures and Complications
- Crime Patterns and Interventions
- Disaster Response and Management
- Esophageal and GI Pathology
- Minimally Invasive Surgical Techniques
- Public Health Policies and Education
University of Pennsylvania
2017-2024
Boston Medical Center
2022-2024
Boston University
2022-2024
McGill University
2023-2024
Lancaster General Hospital
2023-2024
Massachusetts General Hospital
2023-2024
Mount Sinai Hospital
2023-2024
University of Arizona
2023-2024
Temple University Hospital
2023-2024
Medical College of Wisconsin
2023-2024
Whole-blood (WB) resuscitation has gained renewed interest among civilian trauma centers. However, there remains insufficient evidence that WB as an adjunct to component therapy-based massive transfusion protocol (WB-MTP) is associated with a survival advantage over MTP alone in adult patients presenting severe hemorrhage.
To understand the role of mitochondrial uncoupling protein (UCP) in regulating insulin signaling and glucose homeostasis, we created transgenicDrosophila lines with targeted UCP expression producing cells (IPCs). Increased activity IPCs results decreased steady state Ca2+ levels as well PI3K increased FoxO nuclear localization periphery. This reduced systemic is accompanied by a mild hyperglycemia extended life span. test hypothesis that ATP-sensitive potassium (KATP) channels may link...
ABSTRACT Introduction There are no clear recommendations for the perioperative timing and initiation of venous thromboembolism pharmacologic prophylaxis (VTEp) among polytrauma patients undergoing high-risk bleeding orthopedic operative intervention, leading to variations in VTEp administration. Our study examined association between VTE complications interventions nationwide. Methods A retrospective cohort trauma ≥18 years who underwent pelvic, hip, femur fractures within 24 hours admission...
The introduction of laparoscopy has provided trauma surgeons with a valuable diagnostic and, at times, therapeutic option. minimally invasive nature laparoscopic surgery, combined potentially quicker postoperative recovery, simplified wound care, as well growing number viable intraoperative modalities, presents an attractive alternative for many traumatologists when managing hemodynamically stable patients selected penetrating and blunt traumatic abdominal injuries. At the same time, its own...
The burden of firearm violence in US cities continues to rise. role access trauma center care as a system measure with implications for injury mortality has not been comprehensively evaluated.To evaluate the association between geospatial and an urban system.Retrospective cohort study all people 15 years older shot due interpersonal Philadelphia, Pennsylvania, January 1, 2015, August 9, 2021.Geospatial care, defined predicted ground transport time nearest each person shot, derived by network...
Access to pediatric trauma care is highly variable across the United States. The purpose of this study was measure association between center and motor vehicle crash (MVC) mortality in children (<15 years) at US county level for 5 years (2014-2018).The exposure defined as highest present within each county: (1) center, (2) adult 1/2, (3) 3, or (4) no center. Pediatric deaths due passenger crashes on public roads were identified from NHTSA Fatality Analysis Reporting System. Hierarchical...
BACKGROUND Leak following surgical repair of traumatic duodenal injuries results in prolonged hospitalization and oftentimes nil per os treatment. Parenteral nutrition (PN) has known morbidity; however, leak patients often have complex hospital courses resulting barriers to enteral (EN). We hypothesized that EN alone would be associated with (1) shorter duration until closure (2) less infectious complications length stay compared PN. METHODS This was a post hoc analysis retrospective,...
Introduction The utility of pancreaticoduodenectomy (PD) for high-grade traumatic injuries remains unclear and data surrounding its use are limited. We hypothesized that PD does not result in improved outcomes when compared with non-PD surgical management grade IV–V pancreaticoduodenal injuries. Methods This is a retrospective, multicenter analysis from 35 level 1 trauma centers January 2010 to December 2020. Included patients were ≥15 years age the American Association Surgery Trauma...
BACKGROUND Duodenal leak is a feared complication of repair, and innovative complex repairs with adjunctive measures (CRAM) were developed to decrease both occurrence severity when leaks occur. Data on the association CRAM duodenal are sparse, its impact outcomes nonexistent. We hypothesized that primary repair alone (PRA) would be associated decreased rates; however, improved recovery do METHODS A retrospective, multicenter analysis from 35 Level 1 trauma centers included patients older...
Collecting system duplication is marked by a variety of clinical syndromes. Bilateral and obstructed duplicated systems, particularly with asymmetric levels duplication, are rare typically due to ureteric bud development anomalies. The infrequency which this condition exists makes it formidable challenge for physicians patients. To our knowledge, we present the first case report bilateral obstruction bilaterally collecting systems. In case, 52-year-old male complaining low back pain,...
Damage-control resuscitation (DCR) improves survival in severely bleeding patients. However, deviating from balanced transfusion ratios during a may limit this benefit. We hypothesized that maintaining DCR is independently associated with improved survival.This was secondary analysis of the Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study. Patients receiving >3 U packed red blood cells (PRBCs) any 1-hour period over first 6 hours and surviving beyond 30 minutes...
Objective: We aimed to determine whether gentrification predicts the movement of shooting victims over time and if this process has decreased access care. Background: Trauma centers remain fixed in space, but populations they serve do not. Nationally, displaced disadvantaged communities most at risk for violent injury, potentially decreasing This not been studied, an increase only 1 mile from a trauma center increases mortality up 22%. Methods: performed cross-sectional study utilizing...
BACKGROUND The burden of enterocutaneous fistula (ECF) after emergency general surgery (EGS) has not been rigorously characterized. We hypothesized that ECF would be associated with higher rates postdischarge mortality and readmissions. METHODS Using the 2016 National Readmission Database, we conducted a retrospective study adults presenting for gastrointestinal (GI) surgery. Cases were defined as emergent if they nonelective admissions an operation occurring on hospital day 0 or 1. used...
BACKGROUND Firearm homicides (FH) are a major cause of mortality in the United States. law implementation is variable across states, and legislative gaps may represent opportunities for FH prevention. For each state, we sought to identify which firearm category would have been most effective if implemented how it been. METHODS We conducted retrospective cohort study examining effects laws on rates 48 contiguous US states 2010 2019. Data were obtained from CDC WONDER FBI UCR databases, State...
Cervical spinal cord injuries often necessitate ventilator support (VS). Prolonged endotracheal tube use has conveyed substantial morbidity in prospective study. Tracheostomy is recommended if VS anticipated to be 7 days or longer, which defines prolonged ventilation (PV). Identifying these patients on arrival and before tracheostomy need readily evident could prevent while lowering hospital costs. We aimed create a score (trach score) identify requiring PV who benefit from immediate...
Primary urethral carcinoma is extremely rare and marked by a variety of clinical symptoms. diverticulum still rarer clear cell adenocarcinoma the urethra particularly uncommon (Swartz et al., 2006). Such infrequency has led to inadequate management guidance in literature for disease that often late presentation carries substantial morbidity mortality. This treatable but grave deserves definitive curative treatment. We present first published instance which it was treated with robotic...