A5061812184- Wound Healing and Treatments
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Burn Injury Management and Outcomes
- Ocular Surface and Contact Lens
- Homicide, Infanticide, and Child Abuse
- Knee injuries and reconstruction techniques
- Anatomy and Medical Technology
- Mesenchymal stem cell research
- Transplantation: Methods and Outcomes
- Connective tissue disorders research
- TGF-β signaling in diseases
- CRISPR and Genetic Engineering
- Renal Transplantation Outcomes and Treatments
- Renal and related cancers
- Whipple's Disease and Interleukins
- Innovations in Medical Education
- Sports injuries and prevention
- Pregnancy and preeclampsia studies
- Abdominal Trauma and Injuries
- Abdominal Surgery and Complications
- Clinical Nutrition and Gastroenterology
- Dermatologic Treatments and Research
- Myasthenia Gravis and Thymoma
- Biomedical Ethics and Regulation
University of California, Los Angeles
2003-2025
Mount Sinai Hospital
2024
Orthopaedic Institute for Children
2019
Creative Commons
2018
UCLA Health
2018
University of Oregon
2011-2012
Texas A&M University
2011
Abstract Blocking transforming growth factor (TGF)β1 signal transduction has been a central strategy for scar reduction; however, this approach appears to be minimally effective. Here, we show that fibromodulin (FMOD), 59-kD small leucine-rich proteoglycan critical normal collagen fibrillogenesis, significantly reduces formation while simultaneously increasing strength in both adult rodent models and porcine wounds, which simulate human cutaneous repair. Mechanistically, FMOD uncouples...
Purpose.: We analyzed the expression of angiogenesis-related factors in corneal tissues that had undergone previously autologous cultivated oral mucosal epithelial transplantation (COMET). Methods.: Six eyes from four chemically- and two thermally-injured patients with limbal stem cell deficiency who received COMET to promote wound healing were studied retrospectively. Immunoconfocal microscopy was performed on specimens after COMET, as well normal corneas, conjunctiva, mucosa for keratin 8,...
Activated myofibroblasts deposit extracellular matrix material to facilitate rapid wound closure that can heal scarlessly during fetal development. However, adult exhibit a relatively long life and persistent function, resulting in scarring. Thus, understanding how tissue regeneration differs may serve identify factors promote more optimal healing adults with little or less We previously found matricellular proteoglycan fibromodulin is one such factor promoting repair, but the underlying...
Introduction The utility of pancreaticoduodenectomy (PD) for high-grade traumatic injuries remains unclear and data surrounding its use are limited. We hypothesized that PD does not result in improved outcomes when compared with non-PD surgical management grade IV–V pancreaticoduodenal injuries. Methods This is a retrospective, multicenter analysis from 35 level 1 trauma centers January 2010 to December 2020. Included patients were ≥15 years age the American Association Surgery Trauma...
Tumorigenicity is a well-documented risk to overcome for pluripotent or multipotent cell applications in regenerative medicine. To address the emerging demand safe sources tissue regeneration, we established novel, protein-based reprogramming method that does not require genome integration oncogene activation yield fibromodulin (FMOD)-reprogrammed (FReP) cells from dermal fibroblasts. When compared with induced stem (iPSCs), FReP exhibited superior capability bone and skeletal muscle...
Abstract Transplantation of cultivated human limbo‐corneal epithelial (HLE) cells has been recognized as an effective stem cell (SC) therapy for treating corneal SC deficiency caused by burn or other diseases. With this technique, cryo‐preserved intact amniotic membrane (IAM) successfully used a culture substrate and carrier, is reported to preferentially preserve HLE stem/progenitor in vitro. However, little known about what factors released are involved the progenitor cell‐preserving...
We present a rare case of traumatic maternal gunshot wound (GSW) that resulted in fetal death due to direct injury. A 21-year-old 25 week G3P1011 female with no past medical history (PMH) presented the Emergency Department (ED) after sustaining GSW her left buttock while sitting car. She an acute comminuted fracture iliac bone, and passage bullet through cranium terminating near placenta. Management consisted immediate resuscitation, imaging, emergent abdominal exploration leading delivery...
A multicentre trial was conducted to evaluate a new test for anti-gliadin antibodies (AGA) in serum (Coeliac Screening Kit, CSK, Medical Innovations Limited, Artarmon, NSW, Australia). The showed excellent reproducibility both IgA and IgG detection. average intraassay coefficient of variation (CV) 3.0% 2.4% (n = 6), while the interassay CV 6.4% 4.3% 3). By defining positive as elevated, sensitivity 93% untreated coeliacs 75) observed. corresponding specificities healthy adults 130) children...
PURPOSE: Skeletal muscle, one of the most commonly injured tissue, is easily lost by severe injuries from car accidents, natural disasters, or salvage surgeries for tumors. Unfortunately, skeletal muscle mass has limited repair capacity. Direct transplantation committed myoblasts hindered inadequate cell availability, spreading, and poor survivability implanted cells. In addition, using mesenchymal stem cells tissue regeneration always accompanied painful, invasive procedures (i.e., biopsy,...
In pigs, endometrial functions are regulated primarily by progesterone (P4) and placental factors including estrogen. The high P4 levels throughout pregnancy maintain secretion of histotroph from uterine epithelia, necessary for placentation conceptus development. apical domain luminal epithelium (LE) mediates the complex between uterus trophoblast/chorion in epitheliochorial placenta pigs. LE cells also interact with adjacent underlying basement membrane through their basolateral domains....
Introduction: Rejection (ACR) and infectious enteritis (IE) remain formidable obstacles to successful intestinal transplantation (ITx). While endoscopy/biopsy, stool studies the gold standard for diagnosis treatment, each have limitations. Development of a non-invasive monitoring assay(s) is crucial. To this end, several tests been proposed but none widely validated. In study, we examined use immune monitors ACR or IE. Materials: A retrospective review single-center prospective database ITx...