A5019900162- Spaceflight effects on biology
- Bone health and osteoporosis research
- TGF-β signaling in diseases
- Wnt/β-catenin signaling in development and cancer
- CRISPR and Genetic Engineering
- Developmental Biology and Gene Regulation
- Radiation Therapy and Dosimetry
- Axon Guidance and Neuronal Signaling
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Body Composition Measurement Techniques
- S100 Proteins and Annexins
- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Congenital Diaphragmatic Hernia Studies
- Anesthesia and Neurotoxicity Research
- Sports injuries and prevention
- Craniofacial Disorders and Treatments
- Hedgehog Signaling Pathway Studies
- Vitamin D Research Studies
- 3D Printing in Biomedical Research
- Bone Metabolism and Diseases
- Pluripotent Stem Cells Research
- Renal and related cancers
- Fibroblast Growth Factor Research
University of California, Los Angeles
2014-2023
UCLA Health
2018
Creative Commons
2018
First Hospital of China Medical University
2017
China Medical University
2017
Sichuan University
2017
Understanding the axis of human microbiome and physiological homeostasis is an essential task in managing deep-space-travel-associated health risks. The NASA-led Rodent Research 5 mission enabled ancillary investigation gut microbiome, varying exposure to microgravity (flight) relative ground controls context previously shown bone mineral density (BMD) loss that was observed these flight groups. We demonstrate elevated abundance Lactobacillus murinus Dorea sp. during control through...
ABSTRACT Bone morphogenetic proteins (BMPs) are crucial regulators of chondrogenesis. BMPs transduce their signals through three type I receptors: BMPR1A, BMPR1B, and ACVR1/ALK2. Fibrodysplasia ossificans progressiva (FOP), a rare disorder characterized by progressive ossification connective tissue, is caused an activating mutation in Acvr1 (the gene that encodes ACVR1/ALK2). However, there few developmental defects associated with FOP. Thus, the role ACVR1 chondrogenesis during development...
ABSTRACT Contactin-associated protein-like 4 (Cntnap4) is a member of the neurexin superfamily transmembrane molecules that have critical functions in neuronal cell communication. Cntnap4 knockout mice display decreased presynaptic gamma-aminobutyric acid (GABA) and increased dopamine release associated with severe, highly penetrant, repetitive, perseverative movements commonly found human autism spectrum disorder patients. However, no known function has been revealed besides nervous system....
Trabecular bone is frequently studied in osteoporosis research because changes trabecular are the most common cause of osteoporotic fractures. Dual energy X-ray absorptiometry (DXA) analysis specific to bone-rich regions crucial longitudinal research. The purpose this study define a novel method for accurately analyzing mice via DXA. This will be utilized analyze scans obtained from International Space Station an upcoming microgravity-induced loss. Thirty 12-week-old BALB/c were studied. was...
Abstract Microgravity-induced bone loss results in a 1% mineral density monthly and can be mission critical factor long-duration spaceflight. Biomolecular therapies with dual osteogenic anti-resorptive functions are promising for treating extreme osteoporosis. We previously confirmed that NELL-like molecule-1 (NELL-1) is crucial maintenance. further PEGylated NELL-1 (NELL-polyethylene glycol, or NELL-PEG) to increase systemic delivery half-life from 5.5 15.5 h. In this study, we used...
Tumorigenicity is a well-documented risk to overcome for pluripotent or multipotent cell applications in regenerative medicine. To address the emerging demand safe sources tissue regeneration, we established novel, protein-based reprogramming method that does not require genome integration oncogene activation yield fibromodulin (FMOD)-reprogrammed (FReP) cells from dermal fibroblasts. When compared with induced stem (iPSCs), FReP exhibited superior capability bone and skeletal muscle...
ABSTRACT NELL-1, an osteoinductive protein, has been shown to regulate skeletal ossification. Interestingly, interstitial 11p14.1-p15.3 deletion involving the Nell-1 gene was recently reported in a patient with short stature and delayed fontanelle closure. Here we sought define role of endochondral ossification by investigating Nell-1-specific inactivation Col2α1-expressing cell lineages. Nell-1flox/flox; Col2α1-Cre+ (Nell-1Col2α1KO) mice were generated for comprehensive analysis....
PURPOSE: Skeletal muscle, one of the most commonly injured tissue, is easily lost by severe injuries from car accidents, natural disasters, or salvage surgeries for tumors. Unfortunately, skeletal muscle mass has limited repair capacity. Direct transplantation committed myoblasts hindered inadequate cell availability, spreading, and poor survivability implanted cells. In addition, using mesenchymal stem cells tissue regeneration always accompanied painful, invasive procedures (i.e., biopsy,...
Understanding the impact of human microbiome and physiological homeostasis is an essential task in managing deep-space travel associated health risks. The NASA led Rodent Research 5 mission enabled robust investigation gut bone through four rodent cohorts: 1) ISS, constant microgravity exposure; 2) ISS_G, terrestrial control for ISS; 3) LAR, initial exposure, then returned alive to Earth recovery; 4) LAR_G, LAR. We demonstrated ISS cohort maintained elevated microbial diversity with LAR...