A5085001178- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Oral microbiology and periodontitis research
- Crustacean biology and ecology
- Bone health and osteoporosis research
- Spaceflight effects on biology
- Bacteriophages and microbial interactions
- Marine Biology and Ecology Research
- Genetics, Aging, and Longevity in Model Organisms
- Microbial Applications in Construction Materials
- Marine and coastal plant biology
- Technology Assessment and Management
- Probiotics and Fermented Foods
- Sports and Physical Education Research
- Salivary Gland Disorders and Functions
- Marine and fisheries research
- Coral and Marine Ecosystems Studies
- Marine Biology and Environmental Chemistry
- Cephalopods and Marine Biology
- Oral Health Pathology and Treatment
- Diet and metabolism studies
- S100 Proteins and Annexins
- Cell Adhesion Molecules Research
- Insect Resistance and Genetics
- Anesthesia and Neurotoxicity Research
University of Washington
2020-2023
University of Idaho
2022
Western Washington University
2022
University of Oregon
2018-2021
Understanding the axis of human microbiome and physiological homeostasis is an essential task in managing deep-space-travel-associated health risks. The NASA-led Rodent Research 5 mission enabled ancillary investigation gut microbiome, varying exposure to microgravity (flight) relative ground controls context previously shown bone mineral density (BMD) loss that was observed these flight groups. We demonstrate elevated abundance Lactobacillus murinus Dorea sp. during control through...
Abstract To investigate the timing and intensity of winter spawning by coastal invertebrates, we enumerated embryos in plankton samples collected daily time series from January to March 2014 (79 d), 2015 (73 2016 (74 d). Samples were near mouth Coos Bay estuary Oregon. We several hundred different morphologically distinct types larvae representing at least five phyla. Forty‐three embryo abundant enough (abundance > 500 over series) enable statistical analysis. Twenty these identified...
Objectives/Goals: The overall goal of this project is to determine bacterial transcriptional signatures from clinical sputum and assess their potential monitor treatment response predict the outcome drug therapy in patients with tuberculosis (TB). Methods/Study Population: We are developing a novel transcript capture sequencing (TC-Seq) approach sequence mRNA Mycobacterium (Mtb) analyze transcriptomes samples containing minimal amounts RNA. This protocol generates single-stranded...
Saccharibacteria (TM7), which are obligate episymbionts growing on the surface of host bacteria, may play an important role in oral disease, such as periodontitis (1, 2). As TM7 is a newly cultured lineage its research limited by small number isolated representatives relative to genomes assembled from culture-independent studies (3-5). A comprehensive view both taxa and strain-level variations remains opaque. In this study, we expanded our previously developed baiting method into using many...
Saccharibacteria Nanosynbacter lyticus strain TM7x is a member of the broadly distributed candidate phylum radiation. These bacteria have ultrasmall cell sizes, reduced genomes, and live as epibionts on surfaces other bacteria. The mechanisms by which they establish maintain this relationship are not yet fully understood. transcriptomes epibiont its host Schaalia odontolytica XH001 were captured across establishment symbiosis during both initial interaction stable symbiosis. results showed...
Abstract Developing a laboratory model of oral polymicrobial communities is essential for in vitro studies the transition from healthy to diseased plaque. SHI medium an enriched growth capable supporting biofilms with similar diversity supragingival inocula; however, this does not maintain gram‐negative bacteria more associated subgingival Here, we systematically modified components investigate impacts varying nutrients and develop specific disease‐state community. A plaque sample was...
Many crustacean swimming appendages carry arrays of plumose setae—exoskeletal, feather-like structures long bristles (setae) with short branches (setules) distributed along two sides. Although closely spaced, setae are not physically interconnected. Setal function during as drag-based leaky paddles that push the organism through water. Barnacle cyprids, final, non-feeding larval stage, swim six pairs legs (thoracopods) open and close setal in alternating high-drag power strokes low-drag...
Strain BB001 is cultivated from the human oral cavity on its basibiont bacterial host Actinomyces sp. It an ultrasmall bacterium with a reduced genome that grows obligately host. first member of microbiome taxon 957.
Larvae of barnacles typically pass through naupliar and cyprid planktonic stages before settlement metamorphosis. As the final larval stage, cyprids swim much faster than nauplii in turbulent fluid environments with high shears as they seek habitat. Cyprids six pairs reciprocating thoracic appendages use two anterior antennules during settlement. Our understanding how generate movement is limited due to short stroke intervals (∼5 ms) that impede observations shape trajectory appendages....
While evaluating the effect on lifespan of decreased ribosomal protein (Rp) expression in Drosophila, we discovered a potential function same process for Molybdenum cofactor synthesis 1 (Mocs1) gene. We utilized UAS-GAL4 inducible system, by crossing tissue-specific GAL4 drivers to Harvard Drosophila Transgenic RNAi Project (TrIP) responder lines Rp gene knockdown. also employed negative control that knocked down unrelated (GAL4). Relative genetic background which no driven transgenes were...
ABSTRACT Saccharibacteria Nanosynbacter lyticus strain TM7x is a member of the broadly distributed Candidate Phylum Radiation. These bacteria have ultrasmall cell size, reduced genomes and live as epibionts on surface other bacteria. The mechanisms by which they establish maintain this relationship are not yet fully understood. transcriptomes epibiont its host Schaalia odontolyticus XH001 were captured across establishment symbiosis during both initial interaction stable symbiosis. results...
Understanding the impact of human microbiome and physiological homeostasis is an essential task in managing deep-space travel associated health risks. The NASA led Rodent Research 5 mission enabled robust investigation gut bone through four rodent cohorts: 1) ISS, constant microgravity exposure; 2) ISS_G, terrestrial control for ISS; 3) LAR, initial exposure, then returned alive to Earth recovery; 4) LAR_G, LAR. We demonstrated ISS cohort maintained elevated microbial diversity with LAR...
Here, we report draft genome sequences for nine strains of "Candidatus Nanosynbacter sp. HMT-352." These and their were used to interrogate strain-level variations in host range, gene content, growth dynamics among the phylum Saccharibacteria."