A5111955503- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Transcranial Magnetic Stimulation Studies
- Pancreatic function and diabetes
- Cardiovascular Disease and Adiposity
- Pain Management and Treatment
- Metabolism, Diabetes, and Cancer
- Receptor Mechanisms and Signaling
- Cardiac Valve Diseases and Treatments
- Neuroscience and Neural Engineering
- Cardiac Imaging and Diagnostics
- Ion channel regulation and function
- Sarcoidosis and Beryllium Toxicity Research
- Photoreceptor and optogenetics research
- Chemotherapy-induced cardiotoxicity and mitigation
- S100 Proteins and Annexins
- Cardiac Fibrosis and Remodeling
- Iterative Learning Control Systems
- Nitric Oxide and Endothelin Effects
Hokkaido University
2003-2025
Hokkaido University Hospital
2022-2025
Sapporo University
2024
University of California, Los Angeles
2021-2022
Social Insurance Saitama Chuo Hospital
2021
Texas Cardiac Arrhythmia
2021
UCLA Health
2021
Dokkyo Medical University Saitama Medical Center
2021
Kansai Electric Power (Japan)
1997
NEC (Japan)
1970
Recent studies have demonstrated that sodium-glucose co-transporter-2 inhibitors (SGLT2-i) reduce the risk of atrial fibrillation (AF) in patients with diabetes mellitus (DM), which oxidative stress due to increased reactive oxygen species (ROS) contributes pathogenesis AF. We aimed further investigate this, and examine whether SGLT2-i empagliflozin suppresses mitochondrial-ROS generation mitigates fibrosis.A high-fat diet low-dose streptozotocin treatment were used induce type-2 DM (T2DM)...
Diabetic cardiomyopathy has been reported to increase the risk of fatal ventricular arrhythmia. The beneficial effects selective sodium-glucose cotransporter-2 inhibitor have not fully examined in context antiarrhythmic therapy, especially its direct cardioprotective despite negligible SGLT2 expression cardiomyocytes. We aimed examine empagliflozin (EMPA) treatment on diabetic cardiomyocytes, with a special focus Ca2+ handling. conducted echocardiography and hemodynamic studies studied...
Abstract Epicardial adipose tissue (EAT) is an active endocrine organ that closely associated with occurrence of atrial fibrillation (AF). However, the role EAT in development postoperative AF (POAF) remains unclear. We aimed to investigate association between profile and POAF patients who underwent cardiovascular surgery. obtained samples from 53 evaluate gene expression, histological changes, mitochondrial oxidative phosphorylation (OXPHOS) capacity EAT, protein secretion EAT‐conditioned...
Abstract Background Accurate prediction for survival in individualized patients with cardiac resynchronization therapy a defibrillator (CRT‐D) is difficult. Methods We analyzed the New Japan device treatment registry (JCDTR) database to develop model CRT‐D recipients. Results Four hundred and eighty‐two recipients, at implantation year 2018–2021, QRS width ≥120 ms left ventricular ejection fraction (LVEF) ≤35% baseline, were analyzed. During an average follow‐up of 21 ± 10 months, death...
Background Low‐voltage areas in the left atrium predict atrial fibrillation recurrence after catheter ablation and are associated with adverse outcomes like death, heart failure, stroke. Detecting low‐voltage (LVAs) typically requires invasive procedures, highlighting need for a simple, minimally marker. Vasoactive intestinal peptide (VIP), neuropeptide released during parasympathetic stimulation, affects electrophysiological remodeling fibrillation. We hypothesized that serum VIP could...
Ventricular arrhythmia (VA) is the major cause of death in patients with left ventricular (LV) hypertrophy and/or acute ischemia. We hypothesized that apamin, a blocker small-conductance Ca
Abstract Aims Although patients with heart failure (HF) frequently experience considerable symptom burden and require significant care, most HF do not receive timely intervention due to the absence of a standardized method for identifying those in need palliative care. The Needs Assessment Tool: Progressive Disease‐Heart Failure (NAT: PD‐HF) assesses care needs HF. However, its validity reliability have yet be fully examined. We aimed assess NAT: PD‐HF Japanese Methods prospectively enrolled...
Abstract Introduction Impedance is a crucial parameter in cardiovascular implantable electronic devices (CIEDs). Clinically, most CIEDs measure impedance using low voltage sub‐threshold measurement (LVSM). Although the LVSM of shock (LVSM‐SI) generally comparable with high (HVSI), LVSM‐SI might be inaccurate if peri‐lead tissue degeneration occurs. Methods and Results We present case elevated occurring 8 years post‐lead implantation, possibly attributed to encapsulation right ventricular...
Atrial fibrillation (AF) is an important prognostic determinant in heart failure (HF) with preserved ejection fraction (HFpEF). However, it unclear which HFpEF phenotypes are affected by AF terms of long-term clinical outcomes because a heterogeneous syndrome comorbidities such as coronary artery disease (CAD). In this study we determined the differential significance patients according to CAD status.
This paper deals with a harmonic compensation method using synchronous machine resonant field circuits. Harmonics have become one of the major problems in power systems and lot methods suppression been studied. The authors proposed new excited 6th current. shows that armature inductances for 5th or 7th harmonics decrease when circuits are connected to capacitors resonating at harmonic. variations impedances explained theoretically by Park's equations. optimal capacitances selected so as...
This paper considers the synthesis of passive networks with minimum sensitivity to element tolerances through some classes continuously equivalent transformations. The methods transformations be discussed are those transformerless ones in which port structures invariant. Two approaches problem considered. first is procedure an additional network sought such that augmented network, obtained by parallel connection given and one, original one. second based on linear a number authors. Of...
Stellate ganglia within the intrathoracic cardiac control system receive and integrate central, peripheral, cardiopulmonary information to produce postganglionic sympathetic inputs. Pathological anatomical structural remodeling occurs neurons of stellate ganglion (SG) in setting heart failure (HF). A large proportion SG function as interneurons whose networking capabilities are largely unknown. Current therapies limited targeting activity at level or surgical interventions such stellectomy,...
Abstract Background Not only patients with heart failure (HF), but also their caregivers have reported experiencing distress, depression, anxiety, social isolation, and health problems related to caring for a patient. Needs assessment tools been used in clinical practice identify patients' needs from an early stage, however, relationship caregiver burden the severity of HF they care has not well investigated. Purpose The purpose this study is examine between distress using Assessment Tool:...
Introduction: Identifying low-voltage areas (LVAs) within left atrium (LA) is crucial for predicting atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI). Animal studies have shown that the parasympathetic neurotransmitter vasoactive intestinal peptide (VIP) affects electrophysiological remodeling. Hypothesis: Thus, we hypothesized elevated serum VIP levels might contribute to development of LVAs and concentrations could serve as a biomarker LVA presence in AF patients....