The strain designated Chlamydia trachomatis serovar that was used for experiments in this paper is muridarum, a species closely related to C. (and formerly termed the Mouse Pneumonitis of trachomatis. [corrected]. obligate intracellular pathogen replicates within membrane-bound inclusion acquires host sphingomyelin (SM), process essential replication as well biogenesis. Previous studies demonstrate SM acquired by Brefeldin A (BFA)-sensitive vesicular trafficking pathway, although...

Kidney renal clear cell carcinoma (KIRC) is one of the most prevalent primary malignancies with high heterogeneity in urological system. Growing evidence implies that lactate a significant carbon source for metabolism and plays vital role tumor development, maintenance, therapeutic response. However, global influence lactate-related genes (LRGs) on prognostic significance, microenvironment characteristics, response has not been comprehensively elucidated patients KIRC. In present study, we...

// Hanbo Wang 1, * , Leilei Niu 2, Shaobo Jiang 1 Jing Zhai 3 Ping 4 Feng Kong 5 Xunbo Jin Minimally Invasive Urology Center, Shandong Provincial Hospital affiliated to University, Jinan, China 2 Department of Surgery, The Chinese University Hong Kong, Prince Wales Hospital, Sha Tin, New Territories, SAR, Biochemistry, School Basic Medical Sciences, Taishan Taian, Qilu Central Laboratory, Second These authors contributed equally this work Correspondence to: email: kongfeng@sdu.edu.cn Jin,...

The molecular details of Chlamydia trachomatis binding, entry, and spread are incompletely understood, but heparan sulfate proteoglycans (HSPGs) play a role in the initial binding steps. As cell surface HSPGs facilitate interactions many growth factors with their receptors, we investigated HSPG-dependent C. infection. Here, report novel finding that Fibroblast Growth Factor 2 (FGF2) is necessary sufficient to enhance host cells an manner. FGF2 binds directly elementary bodies (EBs) where it...

Traditional intravesical instillation treatment in bladder cancer has limited efficacy, which results a high frequency of recurrence.The aim this study was to report on an epirubicin (EPI)-loaded magnetic multi-walled carbon nanotube (mMWCNTs-EPI) system for place the current formulation.The mMWCNTs-EPI formulated with carboxylated MWCNTs, Fe3O4 nanoparticles, and EPI. Features antitumor activity were investigated.Under effect external magnets, showed sustained release prolonged retention...

Long noncoding RNAs (lncRNAs) have been shown to play a critical role in cancer development and progression. LncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) is kidney cancer-associated onco-lncRNA involved the progression of renal cell carcinoma (RCC). However, pathological lncRNA MALAT-1 RCC proliferation metastasis remains poorly understood. This study was designed investigate biological mechanism metastasis. The experiments were performed human tissues, lines, nude...

Kidney renal clear cell carcinoma (KIRC) has long been identified as a highly immune-infiltrated tumor. However, the underlying role of pyroptosis in tumor microenvironment (TME) KIRC remains poorly described. Herein, we systematically analyzed prognostic value, TME, response to ICIs, and drug sensitivity pyroptosis-related genes (PRGs) patients based on The Cancer Genome Atlas (TCGA) database. Cluster 2, by consensus clustering for 24 PRGs, presented poor prognosis, likely because...

Bladder urothelial carcinoma (BLCA) is associated with high mortality and recurrence. Although mRNA-based vaccines are promising treatment strategies for combating multiple solid cancers, their efficacy against BLCA remains unclear. We aimed to identify potential effective antigens of the development screen immune clusters select appropriate candidates vaccination. Gene expression microarray data clinical information were retrieved from The Cancer Genome Atlas GSE32894, respectively. mRNA...

Rationale: The bladder is the most common site of foreign bodies in urinary tract. Presenting complaints patients with a body are retention, dysuria, frequent urination, decreased urine volume, nocturia, hematuria, painful erection, as well pain urethra and pelvis. Patient concerns: A 50-year-old married male presented severe lower abdominal dysuria. Diagnoses: plain radiograph pelvis showed metallic dense that was composed many small magnetic balls pelvic region. Interventions: removed...

Abstract The microphthalmia of bHLH‐LZ transcription factor (MiT/TFE) family chromosomal translocation or overexpression is linked with a poor prognosis in clear cell renal carcinoma (ccRCC) elevated recurrence and drug resistance, but the molecular mechanism not fully understood. Here, we investigated whether resistance to sunitinib (Sun), standard treatment for metastatic ccRCC, due up‐regulation programmed death ligand 1 (PD‐L1) by E3 (TFE3). In this study, propose that TFE3 TFEB...

Metabolic reprogramming contributes to the high mortality of advanced stage kidney renal clear cell carcinoma (KIRC), most common cancer subtype. This study aimed identify a metabolism-related gene (MRG) signature improve survival prediction in KIRC patients. We downloaded RNA sequencing data and corresponding clinical information for control samples from The Cancer Genome Atlas database identified, based on an MRG dataset Molecular Signatures Database, 123 MRGs with differential expression...

Abstract Background and Objectives Treatment resistant hypertension (trHTN) is a common clinical problem faced by many clinicians. Laparoscopic adrenalectomy effectively trims blood pressure (BP) elevation secondary to various functional adrenal disorders. However, the impact of on BP within trHTN patients has never been reported. Our present study aims investigate effect management patients, explore predictors for postoperative normalization. Patients Methods In our current study, 117...

Emerging evidence has illustrated that Collagen triple helix repeat containing 1 (CTHRC1) is crucial for tumorigenesis and development. However, the effects of CTHRC1 on bladder cancer progression remain largely unclear. Here, we aim to investigate function mechanism in behaviors cells vitro vivo.Interference assays were applied determine biological functions CTHRC1. The expression was examined by quantitative real time-PCR (qRT-PCR), Western blot immunohistochemical (IHC) analysis. Effects...

Extramedullary plasmacytoma (EMP) is a very rare malignant neoplasm arising from clonal proliferation of atypical plasma cells. Most EMPs involve mucosal lymphoid tissue, particularly in the nasopharyngeal area, respiratory tract, and head neck region. Such neoplasms kidney patients with human immunodeficiency virus (HIV) infection are extremely rare.A 55-year-old male who had been diagnosed HIV 1 year previously presented 2-week history intermittent right abdominal pain gross...

Abstract Background and Objectives Treatment resistant hypertension (trHTN) is a common clinical problem faced by many clinicians. Laparoscopic adrenalectomy effectively trims blood pressure (BP) elevation secondary to various functional adrenal disorders. However, the impact of on BP within trHTN patients has never been reported. Our present study aims investigate effect management patients, explore predictors for postoperative normalization. Patients Methods In our current study, 117...

The aim of this study is to investigate efficacy a traditional Chinese medicine formula (named Xian-Jia-Tang, XJT) on bladder outlet obstruction (BOO) in rats and explore its mechanisms. Total 80 BOO model were established randomly divided into 4 groups: physiological saline, XJT, Cesium Chloride (CC), XJT CC groups. Meanwhile, 12 used as normal control. Bladder weight urodynamics measured. Oxidative stress level mRNA expressions potassium channels gene detected detrusor. protein levels...

Background: Tripartite motif containing 46 was initially identified as the oncogene in several human tumors. However, clinical value and potential functions of tripartite (TRIM46) clear cell renal carcinoma (ccRCC) remained largely unclear. Methods: The expressing patterns, involvement, prognostic values TRIM46 were analyzed using data obtained from TCGA GEO databases. A nomogram constructed to examine outcome patients with ccRCC. We estimated association between tumor immunity Results:...

The occurrence of hypercortisolism resulting from adrenocorticotropic hormone (ACTH)-secreting pheochromocytoma is exceedingly uncommon, with limited documented instances thus far.