A5065477653- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- RNA modifications and cancer
- Diabetes Management and Research
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- Cancer, Lipids, and Metabolism
- Viral-associated cancers and disorders
- Bioactive Natural Diterpenoids Research
- Eosinophilic Disorders and Syndromes
- interferon and immune responses
- Single-cell and spatial transcriptomics
- Bladder and Urothelial Cancer Treatments
- Traditional Chinese Medicine Analysis
- Diabetes and associated disorders
- Neuroendocrine Tumor Research Advances
- Cytomegalovirus and herpesvirus research
- Immunotherapy and Immune Responses
- IgG4-Related and Inflammatory Diseases
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Metabolism, Diabetes, and Cancer
German Center for Diabetes Research
2023-2025
Heinrich Heine University Düsseldorf
2023-2025
Deutsches Diabetes-Zentrum e.V.
2023-2025
Ludwig-Maximilians-Universität München
2023
Helmholtz Zentrum München
2022-2023
Technical University of Munich
2021
Shandong Shierming Eye Hospital
2020
Shandong University of Traditional Chinese Medicine
2017-2020
Abstract Single-cell genomic technologies enable the multimodal profiling of millions cells across temporal and spatial dimensions. However, experimental limitations hinder comprehensive measurement under native dynamics in their tissue niche. Optimal transport has emerged as a powerful tool to address these constraints facilitated recovery original cellular context 1–4 . Yet, most optimal applications are unable incorporate information or scale single-cell atlases. Here we introduce...
In this study, we analyzed the prediction accuracy of an autophagy-related long non-coding RNA (lncRNA) prognostic signature using bladder urothelial carcinoma (BLCA) patient data from The Cancer Genome Atlas (TCGA) database. Univariate and multivariate Cox regression analyses showed significant correlations between five lncRNAs, LINC02178, AC108449.2, Z83843.1, FAM13A-AS1 USP30-AS1, overall survival (OS) among BCLA patients. risk scores based on lncRNA accurately distinguished high-...
Kidney renal clear cell carcinoma (KIRC) is one of the most prevalent primary malignancies with high heterogeneity in urological system. Growing evidence implies that lactate a significant carbon source for metabolism and plays vital role tumor development, maintenance, therapeutic response. However, global influence lactate-related genes (LRGs) on prognostic significance, microenvironment characteristics, response has not been comprehensively elucidated patients KIRC. In present study, we...
Qinghuo Rougan Formula (QHRGF) is a traditional Chinese medicine (TCM) that has been widely apllied to treat uveitis for several decades. However, the inhibitory mechanism of QHRGF in remained be an enigma. The herbal pharmacology data and analysis platform wereused search screen effective components compound injection analyse possible therapeutic targets based on network topology. In addition, various known disease target databases were enraolled, proteins screened, protein-protein...
Kidney renal clear cell carcinoma (KIRC) is the predominant pathological subtype of (RCC) in adults. Long non-coding RNAs (lncRNAs) are an important class gene expression regulators and serve fundamental roles immune regulation. The intent this study to develop a novel immune-related lncRNA signature accurately predict prognosis for KIRC patients. Here, we performed genome-wide comparative analysis profiles 537 patients from Cancer Genome Atlas (TCGA) database. Cox regression...
Kidney renal clear cell carcinoma (KIRC) has long been identified as a highly immune-infiltrated tumor. However, the underlying role of pyroptosis in tumor microenvironment (TME) KIRC remains poorly described. Herein, we systematically analyzed prognostic value, TME, response to ICIs, and drug sensitivity pyroptosis-related genes (PRGs) patients based on The Cancer Genome Atlas (TCGA) database. Cluster 2, by consensus clustering for 24 PRGs, presented poor prognosis, likely because...
In this study, we investigated the prognostic significance of expression N6-methyladenosine (m6A) RNA methylation regulatory genes in kidney renal papillary cell carcinoma (KIRP). RNA-sequencing data analysis showed that 14 20 major m6A were differentially expressed KIRP tissues from The Cancer Genome Atlas (TCGA) database. We constructed a risk signature with three genes, IGF2BP3, KIAA1429 and HNRNPC, based on results univariate LASSO Cox regression analyses. Multivariate confirmed score...
Bladder urothelial carcinoma (BLCA) is associated with high mortality and recurrence. Although mRNA-based vaccines are promising treatment strategies for combating multiple solid cancers, their efficacy against BLCA remains unclear. We aimed to identify potential effective antigens of the development screen immune clusters select appropriate candidates vaccination. Gene expression microarray data clinical information were retrieved from The Cancer Genome Atlas GSE32894, respectively. mRNA...
The molecular programs regulating human pancreatic endocrine cell induction and fate allocation are not well deciphered. Here, we investigated the spatiotemporal expression pattern function of neurogenic differentiation factor 2 (NEUROD2) during endocrinogenesis. Using Crispr-Cas9 gene editing, generated a reporter knock-in transcription (TF) knock-out inducible pluripotent stem (iPSC) line in which open reading frame both NEUROD2 alleles replaced by nuclear histone 2B-Venus...
The consequences of mutations in genes associated with monogenic forms diabetes on human pancreas development cannot be studied a time-resolved fashion vivo. More specifically, if recessive the insulin gene influence pancreatic endocrine lineage formation is still an unresolved question. To model extremely reduced levels patients mutations, we generated novel knock-in H2B-Cherry reporter induced pluripotent stem cell (iPSC) line expressing no upon differentiation to cell-derived (SC-) β...
Abstract Background: Kidney renal clear cell carcinoma (KIRC) is the most common and lethal (RCC) histological subtype. Ferroptosis a newly discovered programmed death serves an essential role in tumor occurrence development. The purpose of this study to analyze ferroptosis-related gene (FRG) expression profiles construct multi-gene signature for predicting prognosis KIRC patients. Methods: RNA-sequencing data clinicopathological patients were downloaded from Cancer Genome Atlas (TCGA)....
Objective: To study the molecular mechanism of LongdanXiegan Tang for treating uveitis. Methods: This was a experimntal study. The Chinese herbal medicine pharmacology data and analysis platform were used to search screen effective components compound injection Tang, analyze its possible therapeutic targets based on network topology. By searching variety known disease target databases, we can uveitis construct active ingredient-disease treatment with component out key nodes. Using...
Objective: To investigate the effects of total glucosides paeony (TGP) on natural killer T (NKT) cell gene expression in liver experimental autoimmune uveitis (EAU) rats. Methods: Experimental study. Forty-five Lewis rats were randomly divided into three groups: normal controls, EAU-stimulated (model group), and treated with TGP (TGP intervention group). Control animals received an emulsion phosphate-buffered saline (PBS) CFA, which was injected subcutaneously. The other two groups...
Abstract Background: Kidney renal clear cell carcinoma (KIRC) is the most common and lethal (RCC) histological subtype. Ferroptosis a newly discovered programmed death serves an essential role in tumor occurrence development. The purpose of this study to analyze ferroptosis-related gene (FRG) expression profiles construct multi-gene signature for predicting prognosis KIRC patients. Methods: RNA-sequencing data clinicopathological patients were downloaded from Cancer Genome Atlas (TCGA)....