A5080582525- Eicosanoids and Hypertension Pharmacology
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
- Adenosine and Purinergic Signaling
- Neurogenesis and neuroplasticity mechanisms
- Electrodeposition and Electroless Coatings
- Nitric Oxide and Endothelin Effects
- Copper Interconnects and Reliability
- Metal and Thin Film Mechanics
- Hormonal Regulation and Hypertension
- Free Radicals and Antioxidants
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- Advanced Surface Polishing Techniques
- Nanofabrication and Lithography Techniques
- Cancer-related cognitive impairment studies
- Dielectric properties of ceramics
- Influenza Virus Research Studies
- Consumer Retail Behavior Studies
- Microwave Dielectric Ceramics Synthesis
- Apelin-related biomedical research
National Chung Hsing University
2024
City of Hope
2022-2024
Agricultural Technology Research Institute
2021-2024
Yuanpei University
2018-2024
Beckman Research Institute
2022-2023
City Of Hope National Medical Center
2022-2023
National Health Research Institutes
2013-2023
National Yang Ming Chiao Tung University
2013-2023
Tufts Children's Hospital
2023
Chung Shan Medical University
2023
Abstract Long noncoding RNAs (lncRNAs) have been implicated in hypoxia/HIF-1-associated cancer progression through largely unknown mechanisms. Here we identify MIR31HG as a hypoxia-inducible lncRNA and therefore name it LncHIFCAR (long HIF-1α co-activating RNA); describe its oncogenic role co-activator that regulates the HIF-1 transcriptional network, crucial for development. Extensive analyses of clinical data indicate level is substantially upregulated oral carcinoma, significantly...
Oxysterols are oxidation products of cholesterol. Cholestane-3β, 5α, 6β-triol (abbreviated as triol) is one the most abundant and active oxysterols. Here, we report that triol exhibits anti-cancer activity against human prostate cancer cells. Treatment cells with dose-dependently suppressed proliferation LNCaP CDXR-3, DU-145, PC-3 reduced colony formation in soft agar. Oral administration at 20 mg/kg daily for three weeks significantly retarded growth xenografts nude mice. Flow cytometric...
Abstract Background Epilepsy is a common brain disorder characterized by chronic predisposition to generate spontaneous seizures. The mechanisms for epilepsy formation remain unknown. A growing body of evidence suggests the involvement inflammatory processes in epileptogenesis. In present study, we investigated monocyte chemoattractant protein-1 (MCP-1) aberrant migration hippocampal progenitors rats after insult status epilepticus (SE). Methods SE was induced with pilocarpine Sprague–Dawley...
The MYC oncogenic transcription factor is acetylated by the p300 and GCN5 histone acetyltransferases. significance of acetylation functions specific lysine (AcK) residues have remained unclear. Here, we show that major p300-acetylated K148(149) K157(158) sites in human (or mouse) main GCN5-acetylated K323 residue are reversibly various malignant nonmalignant cells. Oncogenic overexpression enhances its alters regulation site-specific proteasome deacetylase inhibitors. Acetylation at...
Abstract Background Nutrient limitations often lead to metabolic stress during cancer initiation and progression. To combat this stress, the enzyme heme oxygenase 1 (HMOX1, commonly known as HO-1) is thought play a key role an antioxidant. However, there discrepancy between level of HO-1 mRNA its protein, particularly in cells under stress. O-linked β-N-acetylglucosamine (O-GlcNAc) modification proteins (O-GlcNAcylation) recently discovered cellular signaling mechanism that rivals...
It is generally understood that continuing neuroinflammation after ischemic stroke can exacerbate the brain damage. During inflammatory hematogenous recruitment process, monocytes and macrophages are activated into proinflammatory M1 anti-inflammatory M2 cell types. Inhibition of soluble epoxide hydrolase (sEH) activity has been reported to regulate monocytes/macrophages, attenuates neuroinflammation. This study aimed evaluate whether a selective sEH inhibitor,...
Ischemic stroke triggers inflammatory responses and oxidative stress in the brain, microglia polarization affects degree of neuroinflammation. It has been reported that inhibition soluble epoxide hydrolase (sEH) activity protects brain tissue. However, anti-inflammatory antioxidative effects sEH ischemic are not fully understood. This study aimed to investigate a selective inhibitor, 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA), after stroke. Adult male rats with middle cerebral...
Dipeptidyl peptidase-4 inhibitors (or gliptins), a class of antidiabetic drugs, have recently been shown to protective actions in the central nervous system. Their cellular and molecular mechanisms responsible for these effects are largely unknown. In present study, two structurally different gliptins, sitagliptin vildagliptin, were examined their therapeutic controlled cortical impact (CCI) model moderate traumatic brain injury (TBI) mice. Early post-CCI treatment with sitagliptin, but not...
In this study, BaTiO3–(Bi0.5Na0.5)TiO3 ceramics with various amounts of Ta2O5 dopant were investigated for their ability to enhance high-temperature stability meet X9R specifications. The results compared those the common Nb2O5 additive. best composition appeared be 0.9BaTiO3–0.1(Bi0.5Na0.5)TiO3 2 mol% sintered at 1215 °C, which had a dielectric constant 1386, tanδ value 1.8%, temperature coefficients capacitance (TCCs) −1.3% and 1.2%, electrical resistivities 2.8 × 1012 1.5 1010 Ω·cm 25 °C...
Traumatic brain injury (TBI) often leads to long-term neurocognitive dysfunctions. Adult neurogenesis in the hippocampal dentate gyrus (DG) serves critical functions cognition but can be disrupted by and insult serval forms. In present study, we explore cellular molecular targets of DPP-4 inhibitors (or gliptins) as related function TBI cognitive sequelae. Two structurally different gliptins, sitagliptin vildagliptin, were examined using a controlled cortical impact (CCI) model moderate...
Rationale: Immunosuppression in the tumor microenvironment (TME) is key to pathogenesis of solid tumors.Tumor cell-intrinsic autophagy critical for sustaining both cell metabolism and survival.However, role host immune system that allows cancer cells escape destruction remains poorly understood.Here, we determined if attenuated sufficient induce rejection through reinforced adaptive immunity.Furthermore, whether dietary glutamine supplementation, mimicking autophagy, capable promoting...
Interferon gamma (IFNγ) is a cytokine implicated in the pathogenesis of autoimmune diseases. SAM and HD domain-containing protein 1 (SAMHD1) an IFNγ-inducible that modulates cellular dNTP levels. Mutations human SAMHD1 gene cause Aicardi-Goutières (AG) syndrome, disease sharing similar clinical features with systemic lupus erythematosus (SLE). Klotho anti-inflammatory which suppresses aging through multiple mechanisms. Implication response identified rheumatologic diseases such as SLE....
During B cell development in bone marrow, large precursor cells (large Pre-B cells) proliferate rapidly, exit the cycle, and differentiate into non-proliferative (quiescent) small cells. Dysregulation of this process may result failure to produce functional pose a risk leukemic transformation. Here, we report that AT rich interacting domain 5B ( ARID5B ), acute lymphoblastic leukemia (B-ALL) gene, regulates at stage. In both mice humans, observed significant upregulation expression initiates...
Middle cerebral artery occlusion (MCAO) in rodents is an essential animal model for research focusing on ischemic stroke. To date, several kinds of surgical methods MCAO have been developed and the craniotomy method has advantage direct visualization middle (MCA). at a more proximal site produces better results, but it invasive technique. The aim this study was to evolve technique simulating cortex injury rats.To approach MCA with less procedure, modified rats developed. Besides, receiving...
This article presents the experimental validations on an industrial panel-level produced solid-state multisensor for simultaneously pH, electrical conductivity (EC), and temperature detection of solution. Indium tin oxide (ITO) is adopted as sensing material sensor chip due to its good ion selectivity, EC, linear coefficient resistance (TCR) characteristics. Meanwhile, thin film deposited Ag/AgCl reference electrode surrounding enhance performance. The in glass substrate directly connected...
In this study, we reported a hybrid multi-PNPN channel junctionless field effect transistor (JLFET) with negative capacitance (NC) by simulation. By incorporating ferroelectric HfAlO capacitor NC effect, an extremely low subthreshold swing of 34 mV/decade, very high on/off current ratio and driven voltage were achieved in the NC-enhanced JLFET. This novel device not only improves on-state reduction while scaling down, but also shows great potential for next-generation low-power...
Surgical post-operative adhesions can lead to serious clinical complications. Barrier agent is the broad usage for prevention of adhesions. This study aimed evaluate reducing adhesion efficacy non-animal hyaluronic acid (HA) hydrogel in pigs undergoing conventional laparotomy pelvic surgery. HA was applied eighteen female who underwent laparotomy. The degrees and histopathology were evaluated bilateral uterine horns as well peritoneal sidewall excision. In present study, all animals survived...