A5082710910- Dark Matter and Cosmic Phenomena
- Particle physics theoretical and experimental studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Sepsis Diagnosis and Treatment
- Atomic and Subatomic Physics Research
- Cosmology and Gravitation Theories
- Neutrino Physics Research
- Cancer Research and Treatments
- Cardiac Arrest and Resuscitation
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Disaster Response and Management
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Hemoglobin structure and function
- Endometriosis Research and Treatment
- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- Cancer, Lipids, and Metabolism
- Phytochemical Studies and Bioactivities
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- RNA Research and Splicing
- Immune Response and Inflammation
Ganzhou People's Hospital
2024-2025
Zhejiang Cancer Hospital
2012-2024
Shanghai Jiao Tong University
2022-2024
Yangzhou University
2024
Campbell Collaboration
2023
Chinese Academy of Sciences
2023
University of Chinese Academy of Sciences
2020-2021
Université Lumière Lyon 2
2020
Zhejiang University
2013
Bridge University
2007
Primary and acquired drug resistance is one of the main obstacles encountered in high-grade serous ovarian cancer (HGSC) chemotherapy. Cisplatin induces DNA damage through cross-linking long integrated non-coding RNAs (lincRNAs) play an important role chemical induced DNA-damage response, which suggests that lincRNAs may be also associated with cisplatin resistance. However, mechanism acting on not well understood. Here, we showed expression lin-RECK-3, H19, LUCAT1, LINC00961, linc-CARS2-2...
We report a novel search for the cosmic-ray boosted dark matter using 100 tonne·day full dataset of PandaX-II detector located at China Jinping Underground Laboratory. With extra energy gained from cosmic rays, sub-GeV particles can produce visible recoil signals in detector. The diurnal modulations rate and spectrum are utilized to further enhance signal sensitivity. Our result excludes matter-nucleon elastic scattering cross section between 10^{-31} 10^{-28} cm^{2} masses 0.1 MeV/c^{2}...
To investigate the dynamics of stomata, transpiration, and photosynthesis under varying light intensities CO
Ovarian cancer (OC) is the most lethal malignant gynecological tumor type for which limited therapeutic targets and drugs are available. Enhanced mitochondrial oxidative phosphorylation (OXPHOS), enables cell growth, migration, stem maintenance, a critical driver of disease progression potential intervention target OC. However, current OXPHOS strategy mainly suppresses activity electron transport chain directly cannot effectively distinguish normal tissues from tissues, resulting in serious...
We report results of a search for dark-matter–nucleon interactions via dark mediator using optimized low-energy data from the PandaX-4T liquid xenon experiment. With ionization-signal-only and utilizing Migdal effect, we set most stringent limits on cross section matter masses ranging 30 MeV/c2 to 2 GeV/c2. Under assumption that is photon decays into scalar pairs in early Universe, rule out significant parameter space such thermal relic dark-matter model.Received 4 August 2023Revised 23...
We report the position reconstruction methods and surface background model for PandaX-4T dark matter direct search experiment. This work develops two algorithms: template matching (TM) method photon acceptance function (PAF) method. Both determine horizontal of events based on light pattern secondary scintillation collected by sensors. After a comprehensive evaluation resolution, uniformity, robustness, PAF was selected reconstruction, while TM employed verification. The achieves bulk event...
Abstract Background Programmed cell death 6 (PDCD6) beside its known proapoptotic functions may be a player in survival pathways cancer. The purpose of this study is to further explore the roles PDCD6 epithelial ovarian Methods Lentiviral vector with shRNA for was used investigate effects knockdown on growth, cycle, apoptosis and motility cancer cells. Two hundred twelve tissues were analyzed mRNA expression using RT-PCR. Associations clinical pathological factors, progression free overall...
To study the anticancer mechanism of polyphyllin I (PPI), a Traditional Chinese Medicine, on ovarian cancer cell line HO-8910PM in vitro. Transwell chamber invasive assays were used to investigate inhibitory capacity PPI metastasis. Gene expression profiling chips was screen differentially expressed genes between experiment group and control group. Reverse transcription PCR Western blotting determine mRNA protein levels. With increasing concentration, metastatic cells decreased, with...
Background . Wogonin is a plant monoflavonoid and has been reported to induce apoptosis of cancer cells show inhibitory effect on cell growth. However, the detailed underlying molecular mechanisms are not elucidated. In this study, we investigated biological effects wogonin in human ovarian A2780 cells. Materials Methods We determined changes cycling apoptotic responses Western blot analysis was used measure protein expressions. Results Our results showed that treatment with inhibited...
Based on spot-scale measurements of lysimeter-based water fluxes and chamber-based carbon (ETWML or FSTC), field- scale eddy covariance-based (ETEC FEC), a coupled water-carbon flux model was developed to predicted simultaneously hourly at either spot field in the water-saving irrigated paddy Tai Lake Region China. The integrated Penman-Monteith Farquhar-von Caemmerer-Berry (FvCB) sub-models with Jarvis sub-model, calibrated based measured 2015 validated using data 2016–2017. performance...
Background: Hemorrhagic shock is a common clinic emergency case. The fluid resuscitation method in the presurgical care of hypotensive trauma patients open to debate. This study was conducted evaluate general and pathophysiologic effects controlled treatment severe uncontrolled hemorrhagic shock. Methods: A model rat with active bleeding established 32 Sprague-Dawley rats. rats were randomly divided into control group, no group (NF group), (NS40 aggressive (NS80 group). Each contained eight...
Polyphyllin I (PPI) is an active component in Rhizoma Paridis, which displays extensive pharmacological antitumor activities. In a previous study, we found that polyphyllin exhibited inhibitory effects on cell growth the human ovarian cancer HO-8910PM line, as well promoting apoptosis and inhibition of migration. Furthermore, gene expression was also profiled by microarray, showed numerous genes were altered PPI; three particular note associated with tumor progression, namely, Caspase-9,...
Inhibition of calcium/calmodulin-dependent protein kinase II (CaMKII) results in hypophosphorylation CaMKII substrates and some cases suppresses cell growth. We previously presented the first report human inhibitory protein, hCaMKIINbeta. Here we functional characterization hCaMKIINbeta ovarian cancer cells. showed that was highly expressed normal tissues but not detected adenocarcinoma, indicating decreased expression may be involved pathogenesis adenocarcinoma. As an endogenous inhibitor,...
Cardamonin, a natural chalcone, is reported to induce apoptosis and inhibit cancer cell growth. However, the mechanisms underlying therapeutic effects of cardamonin remain be established. Here, we have focused on cardamonin-induced in ovarian cells, both vitro vivo. The cycle patterns apoptotic responses cells were assessed this study. Western blot was employed determine expression cycle- apoptosis-related proteins. Our results indicate that suppresses growth by inducing G2/M phase arrest...
Abstract Objective To investigate the efficacy and mechanism of ultrasound-targeted microbubble destruction (UTMD) combined with radiotherapy (XRT) on glioblastoma. Methods The enhanced radiosensitization by UTMD was assessed through colony formation cell apoptosis in Human glioblastoma cells (U87MG). Subcutaneous transplantation tumors 24 nude mice implanted U87MG were randomly assigned to 4 different treatment groups (Control, UTMD, XRT, + XRT) based tumor sizes (100–300 mm 3 ). Tumor...
Transglutaminase 2 (TG2) plays important roles in cell survival and cancer progression. In this study, we examined TG2 expression specimen of 194 patients diagnosed with non-small lung (NSCLC), found that the gene was significantly higher tissues as compared to paired incisal marginal or normal tissues. Our data revealed lower level detected had longer disease free overall expression. We also correlated NSCLC recurrence. These results suggest a potential prognosis impact for patients.
Ovarian cancer leads the worst prognosis among all types of gynecologic malignancies, and patients are often diagnosed at an advanced stage. also has a high rate metastasis; however, detailed mechanisms for ovarian prone to metastasis remain unclear. In this study, we used continuous in vitro screening human A2780 cell line establish (A2780-M) which shows invasiveness motility. Compared parental cells, A2780-M cells express elevated protein levels CD44, CD133, CD34, β-catenin. more resistant...