A5100368130- Traditional Chinese Medicine Analysis
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Medicinal Plant Pharmacodynamics Research
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Studies
- Ginseng Biological Effects and Applications
- Gut microbiota and health
- Phytochemistry and Biological Activities
- Cardiac Arrest and Resuscitation
- Chromatography in Natural Products
- Molecular Biology Techniques and Applications
- Nitric Oxide and Endothelin Effects
- Corneal Surgery and Treatments
- Cardiac Fibrosis and Remodeling
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Advanced MRI Techniques and Applications
- Coronary Interventions and Diagnostics
- Diabetes Management and Research
- Acute Ischemic Stroke Management
- Calpain Protease Function and Regulation
- Brain Tumor Detection and Classification
- Flavonoids in Medical Research
- Biological and pharmacological studies of plants
Huazhong University of Science and Technology
2007-2024
Union Hospital
2022-2024
Tongji Hospital
2013-2023
Shaanxi University of Chinese Medicine
2022-2023
Shanxi Medical University
2022-2023
Beijing University of Chinese Medicine
2007-2023
Shanxi Academy of Medical Sciences
2023
Changchun University of Chinese Medicine
2022
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2022
Tongji University
2021
International hospital-based studies have indicated a high risk of cognitive impairment after stroke, evidence from community-based in China is scarce. To determine the prevalence post-stroke (PSCI) and its subtypes stroke survivors residing selected rural urban Chinese communities, we conducted community-based, cross-sectional study 599 patients accounting for 48% all registered 4 who had suffered confirmed strokes undergone assessments via Montreal Cognitive Assessment (MoCA), Mini-Mental...
Abstract Cardiac fibrosis critically injured the cardiac structure and function of hypertensive patients. However, anti‐fibrotic strategy is still far from satisfaction. This study aims to determine effect mechanism Pirfenidone (PFD), an anti‐lung medicine, in treatment heart failure induced by pressure overload. Male C57BL/6 mice were subjected thoracic aorta constriction (TAC) or sham surgery with vehicle, PFD (300 mg/kg/day) Captopril (CAP, 20 mg/kg/day). After 8 weeks surgery, tested...
AIM:To investigate the anti-tumor effects of paeonol in gastric cancer cell proliferation and apoptosis vitro vivo . METHODS:Murine line mouse forestomach carcinoma (MFC) or human SGC-7901 was cultured presence absence paeonol.Cell determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, cycle flow cytometry TUNEL staining.Tumor growth after subcutaneous implantation MFC cells mice monitored, treatment with were determined. RESULTS:In , caused dose-dependent...
In this study, 2-(N-pyrrolidine-alkyl) tanshinones bearing pyrrolidine groups were synthesized and the antibacterial mechanism was explored. These derivatives selectively elicited activity against Gram-positive bacteria. Moreover, their activities time-, concentration-dependent persistent. It appeared that Fenton-mediated hydroxyl radicals involved, disruption of cell membranes observed. This study indicates might be potential candidates as agents.
Background: Hyperglycemia on admission has been found to elevate risk for mortality and adverse clinical events after acute myocardial infarction (AMI), but there are evidences that the relationship of blood glucose may differ between diabetic nondiabetic patients. Prior studies in China have provided mixed results limited by statistical power. Here, we used data from a large, nationally representative sample patients hospitalized with AMI 2001, 2006, 2011 assess if is prognostic value this...
Background . Myocardial infarction (MI) is the most severe manifestation of cardiovascular disease. Xuefu Zhuyu Capsule (XFC), a proprietary Chinese medicine, widely used in various diseases. At present, molecular mechanism XFC remains unclear. Objective To explore anti‐MI effects by combining network pharmacology and experiments. Methods TCMSP, GeneCards, DisGeNET databases were to find target XFC. PPI analysis was performed STRING database. KEGG GO analyses Metascape Database. Molecular...
Abstract Context The association between remnant cholesterol (RC) and gestational diabetes mellitus (GDM) risk is unclear. Objective This study investigated the RC GDM. Methods We used data from Tongji Maternal Child Health Cohort, a prospective cohort in China. Fasting lipid concentrations were measured around 16 weeks’ gestation. was calculated as total minus low-density lipoprotein high-density cholesterol. GDM diagnosed by 75-g oral glucose tolerance test at 24 to 28 Log-Poisson...
Abstract A sensitive and specific liquid chromatographic–electrospray ionization mass spectrometric method was developed for quantification of salvianolic acid B in rat plasma with resveratrol as the internal standard. The analytes were separated on a reversed‐phase column acetonitrile (40%) water (60%) containing 0.75% formic mobile phase at flow rate 1 mL/min. Liquid–liquid extraction adopted sample preparation, determined using electrospray negative spectrometry selective monitoring mode....
Objectives: To elucidate the accuracy and advantages of Multichannel intraluminal impedance-pH monitoring (MII-pH) in diagnosing gastroesophageal reflux-induced chronic cough (GERC). Methods: The patients with suspected GERC were recruited underwent MII-pH, was confirmed by subsequent anti-reflux treatment despite findings MII-pH. Its diagnostic identifying evaluated receiver operating characteristic (ROC) analysis compared that 24-h esophageal pH monitoring. Results: Among 158 completing...
Danggui Shaoyao San (DSS), a herbal formula, has been widely used for decades in China to treat senile dementia and dysmenorrhea. Here, an integrative high-throughput UPLC-Q-TOF-MS/MS method coupled with multivariable data processing approach was established rapidly screening identifying chemical constituents potential bioactive compounds from DSS. Through the comparison mass fragment ions, relevant literature, in-house reference material database MS cleavage mechanism, 150 constituents,...
Computed tomography feature tracking (CT-FT) has emerged as a valuable method for the assessment of cardiac function. However, no studies have investigated usefulness CT-derived assessments left ventricular (LV) strain in coronary artery disease (CAD). Our aim was to evaluate regional LV systolic deformation patients with anterior descending (LAD) stenosis using CT-FT.Seventy-six LAD were enrolled. The divided into four groups according percentage stenosis: ≤25% defined group I (24...
To explore the molecular mechanism by which Shengmaiyin (Codonopsis pilosula) (SMY) improves isoproterenol (ISO)-induced heart failure (HF) in rats via a traditional Chinese medicine (TCM) integrated pharmacology research platform, The Medicine Integrated Pharmacology Platform (TCMIP V2.0).The chemical constituents and drug targets of SMY medicines were identified through TCMIP, HF disease target information was collected. A prescription medicinecomponent- core network constructed TCM mining...
To evaluate myocardial strain in patients with different coronary artery disease-reporting and data system (CAD-RADS) levels using the computed tomography (CT) feature tracking technology to investigate relationship of calcium scores (CACs) degree stenosis. We prospectively enrolled 237 consecutive undergo CT angiography. The participants were divided into following groups: control (n = 87), CAD-RADS 1 43), 2 3 38), 4 above 26). Myocardial strains analyzed by commercial software, CACs...
Reactive oxygen species are damaging to cardiomyocytes. H9c2 cardiomyocytes commonly used study the cellular mechanisms and signal transduction in cardiomyocytes, evaluate cardioprotective effects of drugs following oxidative damage. The present developed a robust, automated high throughput screening (HTS) assay identify agents from traditional Chinese medicine (TCM) library using H2O2‑induced damage model cells. Using this HTS format, several hits were identified as by detecting changes...
Positron emission tomography~(PET) systems employ mixed-signal front-end to carry out relatively simple, and <i>ad hoc</i>, processing of the charge pulses generated upon event detection. To obtain, maintain over time, proper calibrations circuitry for generating accurate information is a challenging task due simplicity processing, huge number channels multiplexing input signals found in modern PET systems. It also difficult modify or extend event-processing technologies when needs arise...
In the recent years, a growing number of studies have shown that occurrence myocardial ischemia (MI) is closely related to gut microbiota (GM). The Danshen-Honghua herb pair (DHHP), classic combination in traditional Chinese herbal formulas, has been widely applied throughout history cure cardiovascular disease, exhibiting remarkable clinical efficacy treat ischemic heart disease (IHD). However, intrinsic regulation mechanism DHHP treating MI remains unclear. This study aims investigate...
Recently, competing risk nomograms were widely applied to predict prognosis in numerous tumors other than chordoma. Here, we aimed construct and validate a competing-risk-based prognostic nomogram 3- 5-year cancer-specific death (CSD) patients with spinal pelvic chordoma.All chordoma patient data abstracted from the Surveillance, Epidemiology, End Results (SEER) resource, total of 485 eventually included this study. Multivariate model multivariate Cox used determine independent factors,...
Objective To analyze the clinical characteristics of differentiated thyroid cancer (DTC) patients with nasolacrimal duct obstruction (NLDO) after Iodine-131 ( 131 I) therapy and provide guidance for decision-making. Methods Thirty-one DTC NLDO were retrospectively enrolled from Nuclear Medicine Department Shanxi Bethune Hospital during follow-up I between June 2018 March 2021. Eight hundred seventy-one this period without as control group. Clinical characteristics, including sex, age, dose,...