A5057557797- Traditional Chinese Medicine Studies
- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Lipid metabolism and disorders
- Healthcare and Venom Research
- Microbial Metabolism and Applications
- Medicinal Plants and Bioactive Compounds
- Sirtuins and Resveratrol in Medicine
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Ginseng Biological Effects and Applications
- Heart Failure Treatment and Management
- Heart Rate Variability and Autonomic Control
- Autophagy in Disease and Therapy
- Lipoproteins and Cardiovascular Health
- Ginger and Zingiberaceae research
- Hormonal Regulation and Hypertension
- Cardiac Ischemia and Reperfusion
- Blood Pressure and Hypertension Studies
- Mesenchymal stem cell research
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Neurological Disease Mechanisms and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
Guang’anmen Hospital
2015-2025
China Academy of Chinese Medical Sciences
2009-2021
The estimated glucose disposal rate (eGDR) has been linked to incident cardiovascular disease (CVD) in individuals without diabetes. However, few studies have accounted for long-term cumulative eGDR exposure. aim of this study was explore whether independently associated with CVD over the age 50 years and This used data from China Health Retirement Longitudinal Study (CHARLS) (HRS). calculated as summation average each pair consecutive examinations multiplied by time between these two...
Ischemic heart disease is one of the leading causes mortality worldwide, and thus calls for development more effective therapeutic strategies. This study aimed to identify potential targets coronary (CHD) myocardial infarction (MI) by investigating causal relationship between plasma proteins these conditions.
Background Previous studies indicated that the Fibrosis-4 Index (FIB-4), an evaluation metric for liver fibrosis, is associated with adverse outcomes in coronary artery disease. However, correlation between FIB-4 and myocardial infarction (MI) Chinese patients Type 2 Diabetes Mellitus (T2DM) has not been well-defined. Thus, this study aims to elucidate association MI T2DM patients. Methods Cross-sectional data were collected from at two hospitals China, designated as discovery validation...
Heart failure is a common complication in patients with sepsis, and individuals who experience both sepsis heart are at heightened risk for adverse outcomes. This study aims to develop an effective nomogram model predict the 7-day, 15-day, 30-day survival probabilities of septic intensive care unit (ICU). extracted pertinent clinical data from Critical Medical Information Mart Intensive Care (MIMIC-IV) database. Patients were then randomly allocated into training set test ratio 7:3. Cox...
Background . Myocardial infarction (MI) is the most severe manifestation of cardiovascular disease. Xuefu Zhuyu Capsule (XFC), a proprietary Chinese medicine, widely used in various diseases. At present, molecular mechanism XFC remains unclear. Objective To explore anti‐MI effects by combining network pharmacology and experiments. Methods TCMSP, GeneCards, DisGeNET databases were to find target XFC. PPI analysis was performed STRING database. KEGG GO analyses Metascape Database. Molecular...
Patients with rheumatoid arthritis (RA) have an increased risk of ischemic heart failure (IHF), but the shared mechanisms are unclear. This study analyzed RNA sequencing data from five RA and IHF datasets to identify common biological significant biomarkers. One hundred seventy-seven differentially expressed genes (CDEGs) were identified, enrichment analysis highlighting pathways related sarcomere organization, ventricular myocardial tissue morphogenesis, chondrocyte differentiation,...
We evaluated the effects of Xuefu Zhuyu capsule (XFZY) and Shengmai (SM) on evolution syndromes inflammatory markers in patients with unstable angina pectoris (UAP) after percutaneous coronary intervention (PCI). Ninety UAP PCI were randomly equally assigned to three groups: XFZY group, SM placebo 30 each group. Six syndrome factors (including Qi deficiency, yin yang blood stasis, phlegm, stagnation) 4 (high-sensitivity C-reactive protein (Hs-CRP), endothelins-1 (ET-1), matrix...
The Xuefuzhuyu capsule (XFZY) is widely used for the treatment of ischemic heart disease (IHD) in China. We previously demonstrated that XFZY could reduce apoptosis Sprague-Dawley rat cardiomyocytes with similar effect resveratrol (Res) Hori et al. (2013), although its molecular mechanism underlying this protective still unclear. Silent information regulator transcription 1 (SIRT1) had been to be responsible cardioprotection against ischemia-reperfusion injury via long-term transcriptionally...
The Chinese medicine Huoxue Wentong Formula (HXWTF) was used to treat thoracic obstruction and angina pectoris in clinic, which has not been investigated myocardial ischemia-induced apoptosis angiogenic function. Here we aimed investigate the roles of HXWTF rats with angiogenesis disorders, as well reveal potential mechanisms.Male SD were subjected coronary artery ligation followed by (420, 840 1680 mg/kg/day, p.o.) or isosorbide mononitrate (6.3 treatment for 4 weeks. Electrocardiogram...
Patients with chronic obstructive pulmonary disease (COPD) often present atrial fibrillation (AF), but the common pathophysiological mechanisms between two are unclear. This study aimed to investigate biological of COPD and AF search for important biomarkers through bioinformatic analysis public RNA sequencing databases. Four datasets were downloaded from Gene Expression Omnibus (GEO) database. The overlapping genes both diseases screened by WGCNA analysis, followed protein-protein...