A5033200105- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Analysis
- RNA modifications and cancer
- Ginseng Biological Effects and Applications
- Traditional Chinese Medicine Studies
- Cardiovascular Function and Risk Factors
- MicroRNA in disease regulation
- Advanced MRI Techniques and Applications
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Ferroptosis and cancer prognosis
- Flavonoids in Medical Research
- Genetic Neurodegenerative Diseases
- Vestibular and auditory disorders
- Lipid metabolism and disorders
- Metabolomics and Mass Spectrometry Studies
- Autophagy in Disease and Therapy
- Cytomegalovirus and herpesvirus research
- Medicinal Plants and Bioactive Compounds
- Mitochondrial Function and Pathology
- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Lipoproteins and Cardiovascular Health
- Heart Rate Variability and Autonomic Control
- Microbial Metabolism and Applications
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Guang’anmen Hospital
2017-2025
Huzhou Central Hospital
2020-2023
Beijing Tongren Hospital
2019
Capital Medical University
2019
Ischemic heart disease is one of the leading causes mortality worldwide, and thus calls for development more effective therapeutic strategies. This study aimed to identify potential targets coronary (CHD) myocardial infarction (MI) by investigating causal relationship between plasma proteins these conditions.
Background Previous studies indicated that the Fibrosis-4 Index (FIB-4), an evaluation metric for liver fibrosis, is associated with adverse outcomes in coronary artery disease. However, correlation between FIB-4 and myocardial infarction (MI) Chinese patients Type 2 Diabetes Mellitus (T2DM) has not been well-defined. Thus, this study aims to elucidate association MI T2DM patients. Methods Cross-sectional data were collected from at two hospitals China, designated as discovery validation...
Background . Myocardial infarction (MI) is the most severe manifestation of cardiovascular disease. Xuefu Zhuyu Capsule (XFC), a proprietary Chinese medicine, widely used in various diseases. At present, molecular mechanism XFC remains unclear. Objective To explore anti‐MI effects by combining network pharmacology and experiments. Methods TCMSP, GeneCards, DisGeNET databases were to find target XFC. PPI analysis was performed STRING database. KEGG GO analyses Metascape Database. Molecular...
Patients with chronic obstructive pulmonary disease (COPD) often present atrial fibrillation (AF), but the common pathophysiological mechanisms between two are unclear. This study aimed to investigate biological of COPD and AF search for important biomarkers through bioinformatic analysis public RNA sequencing databases. Four datasets were downloaded from Gene Expression Omnibus (GEO) database. The overlapping genes both diseases screened by WGCNA analysis, followed protein-protein...
Gut microbiome is a complex community of microbes present in the human gut and plays an important role occurrence progression colorectal cancer (CRC). However, relationship between virus CRC has not been fully understood.To explore hot spots research trends field virus.By using bibliometric analysis tool CiteSpace based on articles Web Science Core Collection (WoSCC) database, country, institution, highly cited literature, keywords so were visually analyzed.A total 356 from 2001 to 2023...
Background. Lung cancer (LC) has the highest mortality rate among all other types of in world. T cells are known to be key factor inducing immune response during LC. Objective. In this study, we aimed screen and analyze RNAs associated with CD8(+) activated memory CD4(+) lung adenocarcinomas, a subtype non-small-cell (NSCLC-LUAD). Methods. Gene expression RNA-seq data clinical NSCLC-LUAD were downloaded from XENA database. The divided into low scores high based on Stromal Immune scores....
Background. Myocardial ischemia (MI) is a major public health problem with high mortality and morbidity worldwide. Huoxue Wentong formula (HX), traditional Chinese medicine (TCM) formula, exhibits unambiguous effects on treating MI preventing cardiovascular diseases. However, the molecular mechanism of therapeutic HX remains largely unknown. Objective. This study combined microbiology, metabolomics, network pharmacology to explore relationship between gut microbiota its metabolites in rats...
Psoriasis is a chronic autoimmune disease. Identification of the biomarkers responsible for Traditional Chinese Medicine (TCM) syndromes psoriasis can help researchers recognize different aspects and find novel therapeutic targets treatment psoriasis. The current study investigated levels circulating Mo-MDSCs Mo-MDSC-associated immune factors in peripheral blood patients with TCM syndromes. We found that frequency (CD14+HLA-DR-/low cells) among CD14+ cells from plaque blood-stasis (BS)...
This study aims to develop and validate an optimal model for predicting worsening heart failure (WHF). Multiple machine learning (ML) algorithms were compared, the results interpreted using SHapley Additive exPlanations (SHAP). A clinical risk calculation tool was subsequently developed based on these findings.
Objective:To fomulate a rapid screening questionnaire for benign paroxysmal positional vertigo (BPPV) according to the symptoms of patients with BPPV. Method:A total 276 dizziness participated in this study, and 219 cases were included validity evaluation except 48 who revision 9 inconsistent diagnosis. Subjects divided into BPPV group non-BPPV diagnostic criteria. ①All completed questionnaires based on dizziness, differences between two groups compared. ②Reliability test adopted test-retest...
Thoracic obstruction is mainly attributed to the scope of coronary heart disease in modern medicine, and traditional Chinese medicine(TCM) shows a significant effect treatment thoracic obstruction. In this research, network pharmacology method was carried out systemically study underlying mechanism core herbal compatibility TCM on First, we collected literature about prescriptions for treating from CNKI. Then, prescription database establish by inheritance support platform system(V2.5)...