A5035385820- Inflammasome and immune disorders
- Cancer-related Molecular Pathways
- PI3K/AKT/mTOR signaling in cancer
- Epigenetics and DNA Methylation
- Cell Image Analysis Techniques
- Natural Compounds in Disease Treatment
- Liver Disease Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Traditional Chinese Medicine Analysis
- Cancer Genomics and Diagnostics
- Microtubule and mitosis dynamics
- Vitamin C and Antioxidants Research
- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Psoriasis: Treatment and Pathogenesis
- Vitamin K Research Studies
- Immune Response and Inflammation
- RNA modifications and cancer
- Pharmacological Effects of Natural Compounds
- Atherosclerosis and Cardiovascular Diseases
- DNA Repair Mechanisms
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Esophageal Cancer Research and Treatment
- Autophagy in Disease and Therapy
Guang’anmen Hospital
2012-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2025
China Academy of Chinese Medical Sciences
2012-2020
Beijing Tian Tan Hospital
2020
Capital Medical University
2020
Johns Hopkins University
2017
Xian Yang Central Hospital
2017
Abstract The vitamin K (VK) levels vary greatly among different populations and in regions. Currently, there is a lack of reference intervals for VK healthy individuals, aim this study to establish validate the serum K1 (VK1) K2 (VK2, specifically including menaquinone-4 (MK4) menaquinone-7 (MK7)) some Beijing. Serum VK1, MK4, MK7 were firstly measured by high-performance liquid chromatography mass spectrometry 434 subjects. three indicators established calculating data 2.5 97.5 percentiles....
Imprinted genes are vulnerable to environmental influences during early embryonic development, thereby contributing the onset of disease in adulthood. Monoallelic methylation at several germline imprints has been reported as DNMT1-dependent. However, which these two epigenetic attributes, DNMT1-dependence or allelic methylation, renders imprinted susceptible stressors not determined. Herein, we developed a new approach, referred NORED, identify 2468 DNMT1-dependent DNA patterns mouse genome....
Tanshinone I, one of the components Salvia miltiorrhiza Bunge, exhibits anti-tumor ability and induces autophagy. But mechanisms are not fully understood. This study aims to investigate whether AMP-activated protein kinase dependent pathway is involved in autophagic signaling regulation its relationship with tumor suppression. Breast cancer cells (MDA-MB-231, MCF-7) hepatocellular carcinoma (HepG2) were treated I or vehicle. Acridine orange dyeing transmission electron microscopy employed...
Cell division cycle 6 (cdc6) is a key factor of DNA replication initiation license system and proto-oncogene. It has been detected in some tumor tissues to aid cancer diagnosis many research projects. However, it remains unclear that if cdc6 could be the peripheral blood, just like liquid biopsy, solid patients. The aim this study investigate possibility as biomarker for circulating cells patients with lung cancer.We first expression blood mononuclear (PBMCs) by situ hybridization RNA probe....
Psoriasis is a chronic autoimmune disease. Identification of the biomarkers responsible for Traditional Chinese Medicine (TCM) syndromes psoriasis can help researchers recognize different aspects and find novel therapeutic targets treatment psoriasis. The current study investigated levels circulating Mo-MDSCs Mo-MDSC-associated immune factors in peripheral blood patients with TCM syndromes. We found that frequency (CD14+HLA-DR-/low cells) among CD14+ cells from plaque blood-stasis (BS)...
Histone modification including H3 lysine 79 methylation (H3K79me) plays a key role during gene transcription and DNA damage repair. DOT1L, the sole methyltransferase for three states of H3K79me, is implicated in leukemia, colorectal cancer, dilated cardiomyopathy. However, understanding DOT1L H3K79me these pathways disease pathogenesis has been limited due to difficulty working with protein. For instance, locus-specific or genome-wide binding sites revealed by chromatin immunoprecipitation...
Objective To explore the signification and method of Cut-off verification gray zone setting in chemiluminescent assay. Methods NCCLS EP-12 A2 document defines that C50 is analyte concentration cut off value for immunology qualitative test C5-C95 interval range yields 5% positive results to 95% test.The HBeAg ARCHITECT i2000 were worked out according provided by reagent calibrated i2000, which verified approve character declaimed manufactory or not.Gray was set procedure built；A...
The apolipoprotein C3 gene (APOC3) polymorphisms were reported to be associated with lipid levels. But recent studies showed contradictory results about the associations between APOC3 rs854116 and rs2854117 fasting TG level. This study aimed investigate of two levels, considering other factors such as gender, age ethnicity. Twenty-five eligible 20686 subjects included in this meta-analysis. pooled standardized mean difference (SMD) its 95% confidence interval (CI) used assess differences...
Objective To study the phase Ⅱ clinical efficacy of paclitaxel and cisplatin combined with concurrent radiotherapy in treatment locally advanced esophageal squamous cell carcinoma. Methods Sixty-three cases carcinoma patients were selected from January 2014 to 2016 our hospital. All randomly divided into group (32 cases) control (31 according random number table method. treated three-dimensional conformal radiotherapy, was 5-fluorouracil cisplatin, 21 days for a course treatment,...