A5010231075- Plant-Microbe Interactions and Immunity
- Plant Pathogenic Bacteria Studies
- Legume Nitrogen Fixing Symbiosis
- Monoclonal and Polyclonal Antibodies Research
- Microbial infections and disease research
- Diabetes Treatment and Management
- Plant Parasitism and Resistance
- Endodontics and Root Canal Treatments
- Mycotoxins in Agriculture and Food
- Advanced biosensing and bioanalysis techniques
- Liver Disease Diagnosis and Treatment
- Pharmacology and Obesity Treatment
- Aquaculture disease management and microbiota
- Genetic Syndromes and Imprinting
- Advanced Biosensing Techniques and Applications
- Inflammasome and immune disorders
- Psoriasis: Treatment and Pathogenesis
- Metabolism, Diabetes, and Cancer
- Distributed Control Multi-Agent Systems
- Biocrusts and Microbial Ecology
- Plant Molecular Biology Research
- Mobile Learning in Education
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Oral and Maxillofacial Pathology
Guizhou Minzu University
2024
Stomatology Hospital
2024
Sichuan University
2021-2024
State Key Laboratory of Oral Diseases
2021-2024
Beijing Shijitan Hospital
2020-2024
Capital Medical University
2018-2024
National Clinical Research
2024
Hainan University
2021-2024
Chinese Academy of Sciences
2019-2023
Center for Excellence in Molecular Plant Sciences
2019-2023
Abstract In both animals and plants, the perception of bacterial flagella by immune receptors elicits activation defence responses. Most plants are able to perceive highly conserved epitope flg22 from flagellin, main flagellar protein, most species. However, flagellin Ralstonia solanacearum , causal agent wilt disease, presents a polymorphic sequence (flg22 Rso ) that avoids all studied date. this work, we show soybean has developed versions . Furthermore, identify key residues responsible...
Effector proteins delivered inside plant cells are powerful weapons for bacterial pathogens, but this exposes the pathogen to potential recognition by immune system. Therefore, effector repertoire of a given must be balanced successful infection. Ralstonia solanacearum is an aggressive with large secreted effectors. One these effectors, RipE1, conserved in most R. strains sequenced date. In work, we found that RipE1 triggers immunity N. benthamiana, which requires regulator SGT1, not EDS1 or...
Protease-producing bacteria play vital roles in degrading organic matter of aquaculture system, while the knowledge diversity and bacterial community structure protease-producing is limited this especially tropical region. Herein, 1,179 cultivable strains that belonged to Actinobacteria, Firmicutes, Proteobacteria were isolated from systems, which most abundant genus was Bacillus , followed by Vibrio . The relative abundance sediment generally higher than those water. Twenty-one genera 16...
The soilborne bacterial pathogen Ralstonia solanacearum is one of the most destructive plant pathogens worldwide, and its infection process involves manipulation numerous cellular functions. In this work, we found that R. effector protein RipD partially suppressed different levels immunity triggered by elicitors, including specific responses pathogen-associated molecular patterns secreted effectors. localized in subcellular compartments cells, vesicles, vesicular localization was enriched...
Summary Plant immunity is tightly controlled by a complex and dynamic regulatory network, which ensures optimal activation upon detection of potential pathogens. Accordingly, each component this network target for manipulation Here, we report that RipAC, type III-secreted effector from the bacterial pathogen Ralstonia solanacearum , targets plant E3 ubiquitin ligase PUB4 to inhibit pattern-triggered (PTI). plays positive role in PTI regulating homeostasis central immune kinase BIK1. Before...
Phytochrome interacting factors (PIFs) serve as crucial regulators in the light signal transduction pathway and also mediate signals to regulate secondary metabolite synthesis plants. However, regulator role of PIFs metabolites often varies among different Isorhynchophylline (IRN), an iconic Uncaria rhynchophylla, holds significant medicinal value. Low induces IRN previous research, but U. rhynchophylla have not been studied date. Building on this, we identified a PIF protein, UrPIF3, which...
Regeneration of orofacial bone defects caused by inflammation-related diseases or trauma remains an unmet challenge. Parathyroid hormone 1 receptor (PTH1R) signaling is a key mediator remodeling whereas the regulatory mechanisms PTH1R in oral under homeostatic inflammatory conditions have not been demonstrated direct genetic evidence. Here, we observed that deletion Gli1+ progenitors led to increased osteogenesis and osteoclastogenesis. Single-cell bulk RNA-Seq analysis revealed suppressed...
Background As per the National Medical Products Administration (NMPA) requirements, quality and efficacy of generic drugs must be consistent with those innovator drug. We aimed to evaluate bioequivalence safety metformin hydrochloride sustained-release (MH-SR) tablets (Boke®) developed by Beijing Wanhui Double-crane Pharmaceutical Co. Ltd., China product extended-release (Glucophage®-XR) manufactured Bristol-Myers Squibb Company, New York, NY, in healthy Chinese volunteers.Materials methods...
Breast cancer has a high incidence and mortality rate in women due to metastasis drug resistance which is associated with vasculogenic mimicry (VM). We purposed explore VM formulation breast mechanism of involved EphA2/PIK3R1/CTNNB1 the present study.The expression patient prognosis was analyzed from TCGA data, both gene protein as well were measured human tissue samples collected our study. The relationship between formation its possible regulatory explored.The results bioinformatics...
The utilization of mobile devices in education is a growing trend various subjects. We developed the Dental and Maxillofacial Development Teaching Atlas App, applied it to learning process oral histopathology. aim current study was investigate educational effects atlas-based mobile-assisted teaching field dental medicine, suggest relevant improvements. App encompasses wide range atlases. It harbors features, such as terminology definitions, student communications, teacher–student...
Chronic alcohol intake is associated with an increased risk of alcoholic cardiomyopathy, which may present pathological changes such as myocardial insulin resistance, leading to ventricular dilation and cardiac dysfunction. Although a correlation between microRNA-155 (miR-155) signaling has been identified, the underlying mechanism not elucidated date. The purpose study was determine whether overexpression miR-155-5p in vivo could ameliorate chronic alcohol-induced resistance...
Abstract Effector proteins delivered inside plant cells are powerful weapons for bacterial pathogens, but this exposes the pathogen to potential recognition by immune system. Therefore, effector repertoire of a given must be balanced successful infection. Ralstonia solanacearum is an aggressive with large secreted effectors. One these effectors, RipE1, conserved in most R. strains sequenced date. In work, we found that RipE1 triggers immunity N. benthamiana , which requires regulator SGT1,...
Psoriasis is a chronic autoimmune disease. Identification of the biomarkers responsible for Traditional Chinese Medicine (TCM) syndromes psoriasis can help researchers recognize different aspects and find novel therapeutic targets treatment psoriasis. The current study investigated levels circulating Mo-MDSCs Mo-MDSC-associated immune factors in peripheral blood patients with TCM syndromes. We found that frequency (CD14+HLA-DR-/low cells) among CD14+ cells from plaque blood-stasis (BS)...
This study established and validated an LC-MS/MS method for the ultrasensitive determination of cetagliptin in human plasma. Sample pretreatment was achieved by liquid-liquid extraction with ethyl acetate, chromatographic separation performed on XB-C18 analytical column (50 × 2.1 mm, 5 μm) gradient elution (0.1% formic acid acetonitrile 0.1% acid) at a flow rate 1.0 mL/min. For mass spectrometric detection, multiple reaction monitoring used, ion transitions monitored were m/z 421.2-86.0...