A5108712308- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Head and Neck Cancer Studies
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Genetics and Neurodevelopmental Disorders
- interferon and immune responses
- Global Cancer Incidence and Screening
- Ubiquitin and proteasome pathways
- Respiratory Support and Mechanisms
- Peptidase Inhibition and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Pediatric health and respiratory diseases
- Brain Metastases and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Pleural and Pulmonary Diseases
- Gastric Cancer Management and Outcomes
- AI in cancer detection
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- RNA modifications and cancer
Beijing University of Chinese Medicine
2025
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2025
China Agricultural University
2025
Fudan University
2014-2024
Zhongshan Hospital
2014-2024
State Key Laboratory of Respiratory Disease
2023
Guangzhou Medical University
2023
First Affiliated Hospital of Guangzhou Medical University
2023
Central South University
2023
Second Xiangya Hospital of Central South University
2023
Pleural effusion (PE) is commonly observed in advanced lung cancer and was suggested to contain both cell-free tumor DNA cells. Molecular profiling of PE represents a minimally invasive approach detecting driver mutations for clinical decision making, especially when tissues are not available. The objective this study investigate the efficacy precision gene alterations samples address feasibility use. Methods: Sixty-three metastatic patients with (n=30, cohort 1) or without (n=33, 2) matched...
WW domain-containing oxidoreductase WOX1, also named WWOX or FOR, undergoes Tyr33 phosphorylation at its first N-terminal domain and subsequent nuclear translocation in response to sex steroid hormones stress stimuli. The activated WOX1 binds tumor suppressor p53, both proteins may induce apoptosis synergistically. Functional suppression of by antisense mRNA a dominant negative abolishes p53-mediated apoptosis. Here, we determined that UV light, anisomycin, etoposide, hypoxic rapidly induced...
Background Tissue exudates contain low levels of serum complement proteins, and their regulatory effects on prostate cancer progression are largely unknown. We examined specific components in coordinating the activation tumor suppressors p53 WWOX (also named FOR or WOX1) kinases ERK, JNK1 STAT3 human DU145 cells. Methodology/Principal Findings cells were cultured overnight 1% normal serum, depleted an indicated protein. Under C1q- C6-free conditions, WOX1 ERK mainly present cytoplasm without...
Transforming growth factor β (TGF-β) initiates multiple signal pathways and activates many downstream kinases. Here, we determined that TGF-β1 bound cell surface hyaluronidase Hyal-2 on microvilli in type II TGF-β receptor-deficient HCT116 cells, as by immunoelectron microscopy. This binding resulted recruitment of proapoptotic WOX1 (also named WWOX or FOR) formation Hyal-2·WOX1 complexes for relocation to the nuclei. strengthened catalytic domain with N-terminal Tyr-33-phosphorylated WW...
The role of a small transforming growth factor beta (TGF-β)-induced TIAF1 (TGF-β1-induced antiapoptotic factor) in the pathogenesis Alzheimer's disease (AD) was investigated. physically interacts with mothers against DPP homolog 4 (Smad4), and blocks SMAD-dependent promoter activation when overexpressed. Accordingly, knockdown by interfering RNA resulted spontaneous accumulation Smad proteins nucleus governed SMAD complex. TGF-β1 environmental stress (e.g., alterations pericellular...
// Jean-Yun Chang 1 , Ming-Hui Lee Sing-Ru Lin Li-Yi Yang H. Sunny Sun Chun-I Sze 2 Qunying Hong 3 Yee-Shin 4, 5 Ying-Tsen Chou 6 Li-Jin Hsu 5, 7 Ming-Shiou Jan 8 Cheng-Xin Gong 9 Nan-Shan 1, 6, 8, 10 Institute of Molecular Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, ROC Departments Anatomy and Cell Biology, Department Pulmonary Zhongshan Hospital, Fudan University, Shanghai, PRC 4 Microbiology Immunology, Center for Infectious Disease Signaling Research, Basic...
BACKGROUND The authors built a model for lung cancer diagnosis previously based on the blood biomarkers progastrin‐releasing peptide (ProGRP), carcinoembryonic antigen (CEA), squamous cell carcinoma (SCC), and cytokeratin 19 fragment (CYFRA21‐1). In current study, they examined whether modification of to include relevant clinical information, risk factors, low‐dose chest computed tomography screening would improve performance biomarker panel in large cohorts Chinese adults. METHODS study was...
Introduction More than half of patients with tracheal carcinoma (TC) do not receive radical treatment, but the clinical characteristics, palliative treatment options, and prognosis this group remain unclear. Methods This retrospective study analyzed 94 single primary TC (42 squamous cell [TSCC] 52 adenoid cystic [TACC]) admitted to Emergency General Hospital Dongzhimen Hospital, Beijing University Chinese Medicine. Kaplan-Meier survival curves, Log-rank tests, univariate multivariate Cox AFT...
Yunnan Province, which is located in the mountainous plateau region of China, faces numerous challenges, including population decline rural areas. Achieving coordinated development between transportation and systems crucial for fostering sustainable growth. In this study, we developed a pressure state response (PPSR) model comprehensive transport superiority (TS) that considers influence aviation. We quantified system horizontal across Yunnan’s districts counties period 2013 to 2021,...
ABSTRACT Background Tracheal adenoid cystic carcinoma (TACC) is a rare salivary gland malignant tumor. Previous studies mainly focused on surgery, radiation, and chemotherapy. The purpose of this study to describe more clinical characteristics, treatments, overall survival (OS) TACC. Methods Retrospectively analyzed TACC patients from two medical institutions the SEER database January 2010 December 2021. Survival curves were drawn using Kaplan–Meier method, effects prognosis by multivariate...
BACKGROUND This study applied a combined cancer biomarker panel to clinically identify small cell lung (SCLC) and non–small (NSCLC) in high‐risk population. METHODS The serum levels of 4 biomarkers (progastrin‐releasing peptide [ProGRP], carcinoembryonic antigen [CEA], squamous carcinoma [SCC], cytokeratin 19 fragment [CYFRA21‐1]) were determined 153 patients with high risk (12 new diagnosis SCLC, 52 NSCLC, 89 without cancer). Information about delays was collected through interviews all...
Malignant cancer cells frequently secrete significant amounts of transforming growth factor beta (TGF-β), hyaluronan (HA) and hyaluronidases to facilitate metastasizing target organs. In a non-canonical signaling, TGF-β binds membrane hyaluronidase Hyal-2 for recruiting tumor suppressors WWOX Smad4, the resulting Hyal-2/WWOX/Smad4 complex is accumulated in nucleus enhance SMAD-promoter dependent transcriptional activity. Yeast two-hybrid analysis showed that acts as bridge bind both Smad4....
Zfra is a 31-amino-acid zinc finger-like protein, which known to regulate cell death by tumor necrosis factor (TNF) and overexpressed TNF receptor- or Fas-associated domain proteins (TRADD FADD). In addition, undergoes self-association interacts with c-Jun N-terminal kinase 1 (JNK1) in response stress stimuli. To further delineate the functional properties of Zfra, here we investigated regulation activation p53, WOX1 (WWOX FOR), NF-κB, JNK1 under apoptotic stress. Transiently caused growth...
Chronic obstructive pulmonary disease (COPD) is a risk factor and important coexisting for lung cancer; however, the current status of management COPD in cancer patients not fully described. This study addressed this issue general teaching hospital China.Medical records hospitalized Zhongshan Hospital, Fudan University, between January 2006 December 2010 were reviewed. The definition was according to spirometric criteria Global Initiative Obstructive Lung Disease (GOLD) document. diagnostic...
Abstract Background Previous studies have provided conflicting evidence about the increased overall survival (OS) in lung cancer patients with diabetes mellitus (DM) compared those without DM. This study assessed progression-free (PFS)/OS or DM and tentatively analyzed impact of blood glucose levels on PFS/OS patients. Methods Data were collected from based upon admission records January 2010 to 2012 follow-up 2015 Department Pulmonary Medicine, Zhongshan Hospital, Fudan University,...
Lung cancer has emerged as a leading cause of death in the world. Non-small cell lung (NSCLC) accounts for 75-80% all cancers. Current therapies are ineffective, thus new approaches needed to improve therapeutic ratio. Double stranded RNA (dsRNA)-mediated interference (RNAi) shown promise gene silencing, potential which developing methods therapy NSCLC needs be tested. We report here RNAi induced effective silencing epidermal growth factor receptor (EGFR) gene, is over expressed NSCLC. lines...
Cytological rapid on-site evaluation (ROSE) is becoming an integral technique for improving the performance of bronchoscopic examinations by confirming specimenadequacy and accuracy in real-time. However, time- personnel-consuming nature ROSE limits its application. We constructed artificial intelligence (AI)-based model using deep-learning convolutional neural network (CNN) to assist classifying cytologic whole-slide images (WSIs) as malignant or benign. A total 627 patients with slides...