A5015147461- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- Rock Mechanics and Modeling
- MicroRNA in disease regulation
- HER2/EGFR in Cancer Research
- Neuropeptides and Animal Physiology
- Dam Engineering and Safety
- Monoclonal and Polyclonal Antibodies Research
- Neuroscience and Neuropharmacology Research
- Structural Response to Dynamic Loads
- Immunotherapy and Immune Responses
- Chemical synthesis and alkaloids
- Natural product bioactivities and synthesis
- Landslides and related hazards
- Plant-derived Lignans Synthesis and Bioactivity
- Inflammatory Bowel Disease
- Machine Learning in Bioinformatics
- Phytochemistry and Biological Activities
- Medicinal plant effects and applications
- Chronic Lymphocytic Leukemia Research
- Advanced NMR Techniques and Applications
- Reproductive System and Pregnancy
- Immune cells in cancer
University of Southern California
2019-2025
University of Pittsburgh
2020-2021
National Institute on Drug Abuse
2021
Genomics (United Kingdom)
2020
Shanghai University of Traditional Chinese Medicine
2018
Exosomes are nanosized membranous vesicles secreted by a variety of cells. Due to their unique and pharmacologically important properties, cell-derived exosome nanoparticles have drawn significant interest for drug development. By genetically modifying exosomes with two distinct types surface-displayed monoclonal antibodies, we developed an platform termed synthetic multivalent antibodies retargeted (SMART-Exo) controlling cellular immunity. Here, apply this approach human epidermal growth...
Background: Natural Cordyceps cicadae ( C. ) has been utilized extensively in traditional Chinese medicine to treat chronic renal diseases, heart palpitations, infantile convulsions, and dizziness. However, given its slow growth immoderate exploitation, resources have severely depleted. By contrast, Paecilomyces P. ), as the anamorph stage of , is easy cultivate, this kind cultivated good controllable quality. Purpose: This study aimed compare therapeutic effects on adenine-induced failure...
Introduction High ground stress in deep mining operations results rocks exhibiting mechanical properties that differ from those at shallow depths. This study conducted conventional triaxial compression (CTC) tests to elucidate themechanical behaviors of marble under CTC conditions. Methods Initially, it analyzed energy evolution conditions and developed a damage variable ( D ) expression. Subsequently, we examined impacts confining pressure σ 3 on dissipated W d Poisson’s ratio μ′ proposed...
Introduction The stability evaluation and deformation prediction in geotechnical engineering depend on accurate rock mass mechanical parameters (RMMPs). selection of these directly influences the reliability analysis. conventional techniques used to assess RMMPs face considerable challenges real-world applications, which necessitates need investigate novel approaches. Methods This paper proposes a displacement back-analysis (DBA) approach that utilizes support vector regression (SVR)...
G-protein-coupled receptors (GPCRs) are the largest and most diverse group of cell surface that respond to various extracellular signals. The allosteric modulation GPCRs has emerged in recent years as a promising approach for developing target-selective therapies. Moreover, discovery new GPCR modulators can greatly benefit further understanding signaling mechanisms. It is critical but also challenging make an accurate distinction different groups efficient effective manner. In this study, we...
Increasing attention has been devoted to allosteric modulators as the preferred therapeutic agents for their colossal advantages such higher selectivity, fewer side effects, and lower toxicity since they bind at sites that are topographically distinct from classic orthosteric sites. However, binding pockets not conserved there no cogent methods comprehensively characterize features of with modulators. To overcome this limitation, our lab developed a novel algorithm can quantitatively...
Pinoresinol (PINL) and pinoresinol diglucoside (PDG), two natural lignans found in Eucommia ulmoides Oliv. (Duzhong), have several pharmacological activities. However, there is no report available on their absorption, distribution, metabolism, elimination (ADME) properties. Given the possible wide spectrum of application therapeutic areas, this area should be investigated. This work studied vitro ADME properties PDG PINL, including kinetic solubility, permeability across monolayer cells...