A5101868009- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Cholesterol and Lipid Metabolism
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Fungal Biology and Applications
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- Food Quality and Safety Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Peroxisome Proliferator-Activated Receptors
- Web and Library Services
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Transport Systems and Technology
- Phytochemistry and Biological Activities
- Phytochemistry and biological activity of medicinal plants
- Natural Products and Biological Research
- Mesenchymal stem cell research
- Web Data Mining and Analysis
- Microwave Imaging and Scattering Analysis
- Engineering Education and Pedagogy
- Otitis Media and Relapsing Polychondritis
- Botanical Research and Chemistry
- Maritime Navigation and Safety
Swansea University
2021-2025
Shanghai University of Finance and Economics
2024
Xuzhou Medical College
2024
Ministry of Agriculture and Rural Affairs
2024
Lanzhou University
2024
Institute of Computing Technology
2020
Zhejiang Medicine (China)
2018
XinHua Hospital
2012-2017
Shanghai Jiao Tong University
2017
Zhengzhou City Hospital
2016
Hepatic steatosis reflects the miRNA-related pathological disorder with triglyceride accumulation and lipid peroxidation, which leads to nonalcoholic steatohepatitis, liver fibrosis/cirrhosis, even hepatocellular carcinoma. Circular RNA (circRNA)/miRNA interaction reveals a novel layer of epigenetic regulation, yet miRNA-targeting circRNA remains uncertain in hepatic steatosis. Here, we uncover circRNA_0046367 be endogenous modulator miR-34a that underlies In contrast its expression loss...
Disability worsening in multiple sclerosis (MS) is linked to neurodegeneration. Cholesterol homeostasis essential for normal brain function. CYP46A1, crucial cholesterol turnover and reduced some neurodegenerative diseases, a potential neuroprotective target. We hypothesized that CYP46A1 downregulated MS brains dysbalance. Mass spectrometric analysis of sterols was performed from matched plasma cerebrospinal fluid (CSF) an all-female cohort (n = 32, mean age 33). status recorded at baseline...
Rg1 and Rb1 are two major active compounds of ginseng that facilitate learning memory. The present study aimed to compare the nootropic effects in a scopolamine induced dementia mice model. After 6 12 mg/kg intraperitoneal administration for 7 days, their were assessed using step-down passive avoidance (SD) Morris water maze (MWM) tests, acetylcholinesterase (AChE) activity, acetylcholine (ACh) content serotonin (5-HT) level hippocampus analysed after SD MWM tests. results showed ameliorated...
Fog computing has emerged as a unifying platform to provide computing, communication, and storage for variety of mobile applications. That helps achieve high bandwidth, intelligence, low latency, energy consumption in handling massive networking devices emerging rich multimedia services 5G networks. Current prominence future promises are changing from the Internet Things (IoT) Everything (IoE), which is union people, process, data, things. However, development fog radio access networks...
Background: Natural Cordyceps cicadae ( C. ) has been utilized extensively in traditional Chinese medicine to treat chronic renal diseases, heart palpitations, infantile convulsions, and dizziness. However, given its slow growth immoderate exploitation, resources have severely depleted. By contrast, Paecilomyces P. ), as the anamorph stage of , is easy cultivate, this kind cultivated good controllable quality. Purpose: This study aimed compare therapeutic effects on adenine-induced failure...
BACKGROUND Primary liver cancer is the sixth most common worldwide, with hepatocellular carcinoma (HCC) being prevalent form. Despite current availability of multiple immune or combination treatment options, prognosis still poor, so how to identify a more suitable population extremely important. AIM To evaluate clinical effectiveness combining lenvatinib camrelizumab for patients hepatitis B virus (HBV)-related HCC in Barcelona Clinic Liver Cancer (BCLC) stages B/C, considering various body...
Summary 1. 2,3,4′,5‐Tetrahydroxystilbene‐2‐ O ‐β‐ d ‐glucoside (TSG) has been shown to have an anti‐atherosclerotic effect. Vascular smooth muscle cell (VSMC) proliferation contributes the pathobiology of atherosclerosis. The aim present study was investigate effects TSG on platelet‐derived growth factor (PDGF)‐BB‐induced VSMC and explore molecular mechanisms underlying effects. 2. Cultured rat were pretreated with (l–50 μmol/L) for 1 h, followed by exposure PDGF‐BB (10 ng/mL) 24 after which...
Disordered cholesterol metabolism is linked to neurodegeneration. In this study we investigated the profile of metabolites found in cerebrospinal fluid (CSF) Parkinson's disease (PD) patients. When adjustments were made for confounding variables age and sex, 7α,(25R)26-dihydroxycholesterol a second oxysterol 7α,x,y-trihydroxycholest-4-en-3-one (7α,x,y-triHCO), whose exact structure unknown, be significantly elevated PD CSF. The likely location additional hydroxy groups on are sterol...
This study aimed to investigate the effect of Codonopsis pilosula polysaccharide (CPP) on motility, mitochondrial integrity, acrosome integrity rate, and antioxidant ability sheep sperm after preservation at 4°C.
Background Cell transplantation for myocardial repair is limited by early cell death. Gene therapy with human growth hormone (hGH) has been shown to promote angiogensis and attenuate apoptosis in the experimental animal. This study was conducted explore effects of myoblast-based hGH gene on heart function restoration angiogenesis after infarction, compare differences between myoblast therapy. Methods Myoblasts were isolated from several SD rats, cultured, purified, transfected plasmid...
The number of cases with hepatocellular carcinoma (HCC) are on the increase. aim present study was to investigate clinical effect and relevant mechanism combined sorafenib radiofrequency ablation (RFA) in treatment early small HCC. A total 120 patients HCC that presented during period May 2007 June 2010 were selected divided into surgery (n=60) RF groups according method employed. group treated a laparotomy resection RFA, comparative analysis made between two regard recurrence rates, adverse...
Purpose: To investigate the roles of CFI, genotype-phenotype associations were identified in AAU.Methods: A case–control study was conducted a total 575 subjects consisting 279 AAU patients and 296 healthy controls. Genotypic analyses performed using Sequenom MassARRAY technology. Analyses stratified to series clinical ophthalmic confounding factors.Results: lower frequency CFI-rs13104777 C allele found cohort compared with controls, and, thus, significantly associated pathogenesis (p =...
To analyze the distribution and combined regulation of elements symptom patterns in diagnosis insomnia with Traditional Chinese Medicine (TCM).The samples were collected from patients, diagnosed insomnia, Henan Province Hospital TCM between June 2011 September 2013. The extracted. Next, differentiation, characteristics polysomnography (PSG), these conducted by tests.In total, 286 eligible patients recruited. main locations disease brain heart, phlegm-heat, Yin-deficiency Qi-stagnation. two...
ABSTRACT Cholesterol turnover and CYP46A1 regulation are reported to be crucial for memory functions. An increasing body of evidence shows that activation is able reduce Alzheimer’s Disease (AD) pathological processes. In this study we report the first time overexpression increase 24S-hydroxycholesterol (24OH) induces sex-specific changes in synaptic functions aged mice, being beneficial females while detrimental males. The positive effects on cognition overexpressing female mice were...
Abstract In this study, we examine how local government debt responds to environmental policies in China. We show that when an policy impacts the economy, governments are likely increase issuance, with effect becoming stronger officials have greater career incentives within Chinese bureaucratic system. Over-accumulation of debt, which leads social welfare losses, is closely tied urgency feel secure promotions. Our analysis offers valuable insights for better coordination between fiscal and policies.
<h3>Objectives</h3> To investigate the effects of folic acid supplementation on expression adhesion molecules VCAM·1 in aortic endothelium rats with hyperhomocys teinemia (HHCY) induced by ingestion excess methionine (MET). <h3>Methods</h3> Thirty male SD (200±20 g) were divided into 3 groups (n=10 each group): control group (Control), high MET (MET) and plus folate (MET +folate). The fed respectively normal diet, diet enriched 17 g/kg 0.06 for 45 d. Thelevels total plasma homocysteine (HCY)...