A5005786538- Single-cell and spatial transcriptomics
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- RNA Interference and Gene Delivery
- PARP inhibition in cancer therapy
- Extracellular vesicles in disease
- Adenosine and Purinergic Signaling
- MicroRNA in disease regulation
- Calcium signaling and nucleotide metabolism
- Protease and Inhibitor Mechanisms
- Monoclonal and Polyclonal Antibodies Research
University of Southern California
2022-2025
Nicotinamide adenine dinucleotide (NAD+) is required for a myriad of metabolic, signaling, and post-translational events in cells. Its levels tissues organs are closely associated with health conditions. The homeostasis NAD+ regulated by biosynthetic pathways consuming enzymes. As membrane-bound protein robust hydrolase activity, cluster differentiation 38 (CD38) major degrader NAD+. Deficiency or inhibition CD38 enhances vivo, resulting various therapeutic benefits. metabolic precursor...
T cell receptor (TCR) studies have grown substantially with the advancement in sequencing techniques of repertoire (TCR-Seq). The analysis TCR-Seq data requires computational skills to run TCR tools. However biomedical researchers limited backgrounds face numerous obstacles properly and efficiently utilizing bioinformatics tools for analyzing data. Here we report pyTCR, a notebook-based solution comprehensive scalable analysis. Computational notebooks, which combine code, calculations,...
Abstract T cell receptor (TCR) studies have grown substantially with the advancement in sequencing techniques of repertoire (TCR-Seq). The analysis TCR-Seq data requires computational skills to run TCR tools. However biomedical researchers limited backgrounds face numerous obstacles properly and efficiently utilizing bioinformatics tools for analyzing data. Here we report pyTCR, a notebook-based platform comprehensive scalable analysis. Computational notebooks, which combine code,...