A5100441240- Toxin Mechanisms and Immunotoxins
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Asymmetric Synthesis and Catalysis
- PARP inhibition in cancer therapy
- Multicomponent Synthesis of Heterocycles
- Synthesis and Catalytic Reactions
- Calcium signaling and nucleotide metabolism
- Catalytic C–H Functionalization Methods
- Synthesis and Biological Evaluation
- Synthetic Organic Chemistry Methods
- Cyclopropane Reaction Mechanisms
- HER2/EGFR in Cancer Research
- Catalytic Alkyne Reactions
- Electrostatic Discharge in Electronics
- Sirtuins and Resveratrol in Medicine
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Synthetic Organic Chemistry
- Radiomics and Machine Learning in Medical Imaging
- Asymmetric Hydrogenation and Catalysis
- Axial and Atropisomeric Chirality Synthesis
- Wastewater Treatment and Nitrogen Removal
- Synthesis of Organic Compounds
- Plant Ecology and Soil Science
- Quinazolinone synthesis and applications
Chinese Academy of Sciences
2008-2025
Institute of Hydrobiology
2024-2025
University of Southern California
2018-2024
Tsinghua University
2023-2024
Baidu (China)
2023-2024
State Key Laboratory of Molecular Oncology
2023-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2023
Goethe University Frankfurt
2023
Shenyang Medical College
2023
Goethe Institut
2023
Low melting mixture of maltose–dimethylurea (DMU)–NH4Cl was found to be an inexpensive, non-toxic, easily biodegradable and effective reaction medium in the catalyst-free synthesis quinazoline derivatives. This simple efficient method furnished corresponding quinazolines high yields via one-pot three-component 2-aminoaryl ketones, aldehyde, ammonium acetate under aerobic oxidation conditions.
A novel asymmetric [4+1] annulation of MBH carbonates with dicyano-2-methylenebut-3-enoates has been developed for the first time, providing an efficient and enantioselective synthesis highly functionalized cyclopentenes bearing one all-carbon quaternary stereogenic center.
Understanding the relationship between protein sequence and function remains a longstanding challenge in bioinformatics, to date lion ′s share of related tools parse proteins at domain or motif levels. Here, we define ″protein words ″ as an alternative ″motif for studying functional prediction applications. We first developed unsupervised tool term Protein Wordwise, which parses analyte sequences into by analyzing attention matrices from language model (PLM) through community detection...
4,4-Dicyano-2-methylenebut-3-enoates are employed in the phosphine-catalyzed [3 + 2] cycloaddition with allenoates for first time, affording regiospecific 2]-annulation products moderate to good yields. The multifunctional chiral thiourea-phosphines having an axially binaphthyl scaffold effective catalysts asymmetric variant of this reaction, giving α-regioisomers yields and enantioselectivities.
Abstract A novel Ru 0 ‐ and Rh I ‐catalyzed noncarbonylative carbonylative cycloisomerization of readily available 3‐alkynyl imine derivatives has been developed to provide 3,4‐fused or nonfused pyrrole efficiently in moderate excellent yields. The key steps involve the formation a ruthenium carbenoid intermediate rhodacycle intermediate, respectively. In these reactions, CO can serve as ligand reagent.
Abstract A novel asymmetric [4+2] annulation of vinyl ketones with oxindole‐derived α,β‐unsaturated imines has been developed in the presence a multifunctional thiourea‐phosphine catalyst derived from natural amino acid, providing first phosphine‐catalyzed enantioselective synthesis 2′,3′‐dihydro‐1′ H ‐spiro[indoline‐3,4′‐pyridin]‐2‐ones good yields excellent stereoselectivities under mild conditions. magnified image
Accurate prediction of the structurally diverse complementarity determining region heavy chain 3 (CDR-H3) loop structure remains a primary and long-standing challenge for antibody modeling. Here, we present H3-OPT toolkit predicting 3D structures monoclonal antibodies nanobodies. combines strengths AlphaFold2 with pre-trained protein language model provides 2.24 Å average RMSD Cα between predicted experimentally determined CDR-H3 loops, thus outperforming other current computational methods...
Abstract A novel phosphine‐catalyzed [4+1] annulation of maleimides with 4,4‐dicyano‐2‐methylenebut‐3‐enoates has been developed to afford spirocyclic products, and the serves as C 1 synthons. Moreover, a formal [3+2] between maleic anhydride also achieved, behaved 3 synthon in reaction, thus efficiently affording functionalized cyclopentenones. stable phosphinium‐containing zwitterionic compound is key reactive intermediate both annulations was successfully isolated. Plausible mechanisms...
Abstract Nicotinamide adenine dinucleotide (NAD + )-dependent ADP-ribosylation plays important roles in physiology and pathophysiology. It has been challenging to study this key type of enzymatic post-translational modification particular for protein poly-ADP-ribosylation (PARylation). Here we explore chemical chemoenzymatic synthesis NAD analogues with ribose functionalized by terminal alkyne azido groups. Our results demonstrate that substitution at 3′-OH nicotinamide riboside enables an...
Abstract An asymmetric variant of the intramolecular Rauhut–Currier (RC) reaction can be achieved using a highly nucleophilic multifunctional chiral phosphane; corresponding cyclopentene and cyclohexene derivatives are produced in moderate to good yields with excellent enantioselectivities.
A new approach is developed for generating site-specific antibody-drug conjugates targeted therapy.
Protein poly-ADP-ribosylation (PARylation) is a heterogeneous and dynamic post-translational modification regulated by various writers, readers, erasers. It participates in variety of biological events involved many human diseases. Currently, tools technologies have yet to be developed for unambiguously defining readers erasers individual PARylated proteins or cognate known Here, we report the generation bifunctional nicotinamide adenine dinucleotide (NAD+) characterized diazirine-modified...
To explore the impacts of multiple environmental stressors on animal communities in aquatic ecosystems, we selected protozoa—a highly sensitive group organisms—to assess effect change. conduct this simulation conducted a three-factor, outdoor, mesocosm experiment from March to November 2021. Changes community structure and functional composition protozoan under separate combined effects these three were investigated by warming addition nitrogen, phosphorus, pesticides. The results as...
A simple, convenient, and multicomponent strategy for synthesis of spirooxindole derivatives has been developed. This provides a rapid access to construct diversity‐oriented library spirooxindoles by using three simple readily available isatin, malononitrile or cyanoacetic ester, 1,3‐dicarbonyl compound catalyzed hexamethylenetetramine in water.
A dual-functional metal–organic-framework can selectively sense Zn<sup>2+</sup> and Fe<sup>3+</sup> ions over mixed metal displays size-selective catalysis towards cyanosilylation of aldehydes.
An analogue of nicotinamide adenine dinucleotide (NAD + ) featuring an azido group at 3′-OH adenosine moiety is found to possess high specificity for human PARP1-catalyzed protein poly-ADP-ribosylation.
To investigate the association between clinic-radiological features and glioma-associated epilepsy (GAE), we developed validated a radiomics nomogram for predicting GAE in WHO grade II~IV gliomas.This retrospective study consecutively enrolled 380 adult patients with glioma (266 training cohort 114 testing cohort). Regions of interest, including entire tumor peritumoral edema, were drawn manually. The semantic radiological characteristics assessed by radiologist 15 years experience...
Herbivorous protistan grazers are ubiquitous and abundant in marine temperate freshwater environments. However, little is known about the algivorous ciliates their feeding habits outdoor mass algal cultures. In this study, we report on one hypotrich ciliate, identified as Sterkiella histriomuscorum, from culture of Scenedesmus Arizona, USA. A long-term field survey revealed that species often occurs spring summer, can graze very heavily cells. By isolating cells then observing them via light...