A5100751019- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Neurological Disease Mechanisms and Treatments
- Gastric Cancer Management and Outcomes
- Immune Response and Inflammation
- Reproductive System and Pregnancy
- Cancer Research and Treatments
- Bacteriophages and microbial interactions
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Bacterial Infections and Vaccines
- Helicobacter pylori-related gastroenterology studies
- Galectins and Cancer Biology
- RNA Interference and Gene Delivery
- Vibrio bacteria research studies
- Monoclonal and Polyclonal Antibodies Research
- Tuberculosis Research and Epidemiology
- Antibiotic Resistance in Bacteria
- Acute Ischemic Stroke Management
- Immune cells in cancer
- Extracellular vesicles in disease
- Virus-based gene therapy research
- Autophagy in Disease and Therapy
- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
Education Department of Heilongjiang Province
2025
Bengbu Medical College
2010-2024
Sun Yat-sen University
2021-2023
Hospital of Stomatology, Sun Yat-sen University
2023
Hanzhong People's Hospital
2023
Weatherford College
2023
Peking University
2023
Soochow University
2012-2021
The First Affiliated Hospital, Sun Yat-sen University
2021
Zhongshan Hospital
2021
Carbapenem-resistant
Abstract: Background: Sepsis-Induced Myocardial Injury (SIMI) is a serious complication with high in-hospital and 28-day mortality. Dexmedetomidine (DEX), selective α2-adrenergic receptor agonist, has shown anti-inflammatory cardioprotective effects, but its impact on SIMI prognosis unclear. Methods: This retrospective study used the MIMIC-IV database, including patients diagnosed per Sepsis-3 criteria. Propensity score matching (PSM) balanced baseline characteristics, Cox regression...
Background This study explored the impact of liquid preparations (LPI) derived from Lonicera caerulea L., Polygonatum sibiricum , and Inonotus obliquus on Glucose, Lipid Metabolism in II Diabetes (T2D) mice vivo . Methods A diabetic mouse model was induced by high-fat diet streptozotocin, were randomly divided into 6 groups, after 28 days intervention, key metabolic enzyme activities, relevant biomarker levels, gene/protein expression associated signaling pathways related to glucose...
The “dual carbon” goal is a two-stage carbon reduction proposed by China, including peaking and neutrality, which reflects China’s firm determination to combat climate change realize green development. Carbon emissions from the construction industry are one of main sources growth in so analyzing can help achieve “double goal. In this paper, Sichuan Province chosen analyze its total 2012 2022.Carbon Emission Factor Approach (CEFA) mainly adopted calculate Province, explore entire industrial...
Our previous study showed that the combined Chinese herbs containing scutellaria baicalensis georgi and gardenia jasminoids ellis inhibited atherosclerosis. In this study, we sought to determine if baicalin geniposide could inhibit atherosclerosis through Wnt1 dickkopf-related protein-1 (DKK1).The wild-type ApoE-/- mice were treated with baicalin, geniposide, plus daily by gavage for 12 weeks. Blood lipid levels measured an automatic biochemistry analyzer. Aortic atherosclerotic lesion areas...
The eggplant was mutagenized with ethyl methane sulfonate (EMS) to enhance its genetic variability in our previous paper. In this article, we further analyzed the phenotype of M2 generation mutant eggplants. A total 325 independent families were investigated for phenotypic variation. addition visible variation, chlorogenic acid (CGA) concentrations 26 fruits mutants High Performance Liquid Chromatography assay. Seventeen exhibited significantly higher CGAs than those wild-type. anthocyanin...
PURPOSE Opioids are the primary choice for managing chronic cancer pain. However, many nonopioid therapies currently prescribed pain with little published evidence comparing their efficacy. METHODS Electronic databases were searched randomized controlled trials (RCTs) any systemic pharmaceutical intervention and/or combination thereof in treating The outcome was global efficacy reported as an odds ratio (OR). secondary change intensity a standardized mean difference (SMD). RESULTS We...
e16170 Background: A phase II clinical study was conducted to evaluate the safety and efficacy of toripalimab, a novel PD-1 inhibitor, combined with chemotherapy in patients advanced biliary tract cancers (aBTCs) (NCT03796429). The preliminary results indicated combination treatment is well tolerable effective. Methods: Treatment naive aBTCs received toripalimab (240mg intravenously every three weeks) (gemcitabine 1000 mg/m2 d1, d8 + S-1 40-60mg bid D1-14, Q21d). continued until disease...
// Wei Xu 1 , Li Ying Wang Min Zha Honghong Yao 2 Peter M. Jones 3 and Zilin Sun Department of Endocrinology, Zhongda Hospital, Institute Diabetes, Medical School, Southeast University, Nanjing, China Pharmacology, School Diabetes Research Group, Division & Nutritional Sciences, Faculty Life Sciences Medicine, King's College London, UK Correspondence to: Sun, email: Jones, Keywords : regenerating islet-derived protein 1, exostosin-like glycosyltransferase 3, islet stellate cells, fibrosis,...
To evaluate if the difference between pre- and post-Gd-DTPA(2-) relaxation rate (DeltaR(1)) provides better differentiation of osteoarthritic patients (OA) from healthy subjects (HS) with dGEMRIC, as compared to spin-lattice time (T(1Gd)).Seventeen OA 14 HS underwent 90 minutes postcontrast (Gd-DTPA(2-)) magnetic resonance imaging (MRI) knee, using inversion recovery fast spin-echo and/or Lock-Locker sequences for T(1) mapping. Effect sizes T(1pre), T(1Gd), DeltaR(1) were calculated,...
Objective To analyze basic data and outcomes in Chengdu Stroke Registry.Methods The stroke patients consecutively admitted to Department of Neurology,West China Hospital,Sichuan University since March 1,2002 were prospectively registered.The baseline demographic,risk factors,treatment,and outcome was recorded with standardized register form by trained specialists.The followed up at seven days,one,three,six months one year after onset the for death disability.Results A total 3123 consecutive...
Full scale B-cell activation requires not only receptor (BCR) engagement with antigen, but also costimulatory signals provided by T helper cells through the CD40-CD40 ligand (CD40L) interaction. It is hypothesized that a fusion protein of an antigen and soluble CD40L (CD40LT) would selectively target costimulation to antigen-specific B cells, leading synergy in antibody response. This hypothesis was investigated fusing green fluorescence (GFP), generic mouse CD40LT. Studies revealed...
Problem To examine the immunocontraceptive properties of plasmid pcDNA ‐ mCRISP 1 and compare them to corresponding recombinant ( r‐mCRISP 1). Method study RT‐PCR indirect immunofluorescence were performed observe protein expression in COS ‐7 cells. Three groups mice received three injections 1, or vector, respectively. ELISA Western blot used immune responses immunoreactivity antisera. Sperm‐egg penetration assay was effect anti‐ antibodies vitro fertilization mouse oocytes. Fertility mean...
Orf is caused by the orf virus (ORFV) and a non-systemic, widespread disease afflicting sheep, goats, wild ruminants, humans. Recent outbreaks in sheep goats Jilin other northern Chinese provinces raise concerns about control China. Thirty-five hybridoma clones were constructed from splenocytes of BALB/c mice immunized with natural protein. These hybridomas used to produce antibodies targeting ORFV proteins. Immunological characterization these monoclonal (MAb) showed that 5F2D8 line...
The effector function of natural killer, lymphokine-activated killer cells and T lymphocytes is commonly evaluated by radioactive chromium‑release cytotoxicity assays. In addition to this indirect method, fluorescence assays have been described for the assessment in vitro cell‑mediated cytotoxicity. present study, target were stained with 5‑(and‑6)‑carboxyfluorescein diacetate succinimidyl ester (CFSE), which a stable integrated fluorescent probe that allows be distinguished from one...
Abstract This study was to investigate the protective effects of tea polyphenols on blood-brain barrier (BBB) rats with global cerebral ischemia/reperfusion (GCIR) injury. Sprague Dawley underwent four-vessel occlusion construct model GCIR. Half an hour before complete occlusion, they were treated (TP) (6.4%; 100 or 200 mg/kg) via tail intravenous injection. 24 h after reperfusion, BBB permeability evaluated by measuring brain water content (BWC) and residual amount Evan’s blue dye in...
Abstract Background Glioblastoma remains one of the most lethal brain cancers. T-cell immunoglobulin and mucin domain 1 (Tim-1) is associated with various immune diseases. The molecular mechanism Tim-1 in regulating glioblastoma cell proliferation, invasion, migration still unknown. Moreover, it has shown that miR-133a plays an important role glioblastoma. However, little known about interaction between Methods expression normal tissues was detected by qPCR, Western Blot IHC. After knockdown...