A5071005839- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Gut microbiota and health
- Immune Cell Function and Interaction
- HIV Research and Treatment
- Mycobacterium research and diagnosis
- Monoclonal and Polyclonal Antibodies Research
- Reproductive System and Pregnancy
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Metabolomics and Mass Spectrometry Studies
- Inflammatory Bowel Disease
- Maternal Mental Health During Pregnancy and Postpartum
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Dietary Effects on Health
- Pregnancy and preeclampsia studies
- Influenza Virus Research Studies
- Preterm Birth and Chorioamnionitis
- Tryptophan and brain disorders
- HIV/AIDS Research and Interventions
- Cytomegalovirus and herpesvirus research
Morton Plant North Bay Hospital
2024
Medical University of South Carolina
2017-2024
BayCare Health System
2024
Ralph H. Johnson VA Medical Center
2024
University of South Carolina
2018
Systemic lupus erythematosus (SLE) is characterized by the production of antibodies against self antigens. However, events underlying autoantibody formation in SLE remain unclear. This study was undertaken to investigate role plasma levels, microbial translocation, and microbiome SLE.
Abstract Progesterone plays a protective role in preventing inflammation and preterm delivery during pregnancy. However, the mechanism involved is unknown. Microbial product translocation from permeable mucosa demonstrated as driver of inflammation. To study progesterone pregnancy, we investigated effect physiologic concentrations on tight junction protein occludin expression human gut permeability vitro systemic microbial pregnant women vivo . Plasma bacterial lipopolysaccharide (LPS),...
Increased autoreactive antibodies have been reported in HIV disease; however, the mechanism accounting for autoantibody induction remains unknown. Herein, we show that seasonal influenza vaccination induces production (e.g., IgG anti-nuclear antibody (ANA) and anti-double-stranded DNA (anti-dsDNA)) some viral-suppressed antiretroviral therapy (ART)-treated HIV+ subjects, but not healthy controls. These autoantibodies were derived from antigen-specific B cells activated "bystander" analyzed...
Objective. Blood microbiome has been analyzed in cancer patients using machine learning. We aimed to study whether the plasma represents microbial community gut among with systemic lupus erythematosus (SLE) and healthy controls (HCs). Methods. Paired stool samples from female SLE HCs were assessed for composition by 16S ribosomal RNA sequencing. Results. Decreased alpha diversity compared distinct beta found both SLE. No difference was found; however, decreased HCs. The predominant bacteria...
Blood microbiome is important to investigate microbial-host interactions and the effects on systemic immune perturbations. However, this effort has met with major challenges due low microbial biomass background artifacts. In current study, 16S DNA sequencing was applied analyze plasma microbiome. We have developed a quality-filtering strategy evaluate exclude levels of sequences, potential contaminations, artifacts from analyses. Furthermore, we our technique in three cohorts, including...
There is an intricate interplay between the microbiome and immune response impacting development of normal immunity autoimmunity. However, we do not fully understand how affects production natural-like pathogenic autoantibodies. Peptidoglycan (PGN) a component bacterial cell wall which highly antigenic. PGNs from different bacteria can differ in their regulatory activities. C57BL/6 MRL/lpr mice were intraperitoneally injected with saline or PGN Staphylococcus aureus Bacillus subtilis. Spleen...
Objective Black groups have increased prevalence and accelerated pathogenicity of systemic lupus erythematosus (SLE) compared to other ethnic/racial groups. The microbiome microbial translocation are considered contributing factors SLE disease pathogenesis. However, racial differences in the plasma remain unknown. Methods In current study, we investigated levels (lipopolysaccharide [LPS] zonulin) using 16S RNA sequencing White patients with healthy controls. Results Plasma was versus...
Many health issues prevalent in African American (AA) populations are associated with chronic inflammation and related conditions, including autoimmune diseases, infectious neurologic disorders, metabolic syndromes, others. The current study aims to understand plasma microbiome translocation as a potential trigger for inflammation.
Abstract Although effective antiretroviral therapy (ART) suppresses HIV viral replication, prevents AIDS-related complications, and prolongs life, a proportion of patients fails to restore the patients’ CD4+ T cell number level healthy individuals. Increased mortality morbidity have been observed in these patients. In current study, we investigated role auto-IgGs apoptosis recovery cross-sectional study. All HIV+ subjects were on viral-suppressive ART treatment with different degree...
It is recommended that HIV-infected individuals receive annual influenza vaccination due to their high susceptibility infection, especially among women. However, there have been few studies investigating sex-related responses vaccine in antiretroviral therapy (ART)-treated individuals.In this study, 26 aviremic ART-treated and 16 healthy controls were enrolled the current study. Blood was collected prior (D0), on days 7-10 (D7) 14-21 (D14) following administration of 2013-2014 seasonal...
Abstract Background The process of events underlying autoantibody production in systemic lupus erythematosus (SLE) is unknown. Methods Plasma from 36 female African-Americans (18 unrelated healthy controls (UHCs) and 18 first-degree relatives SLE patients (FDRs)) were assessed for autoantibodies by array, lipopolysaccharide (LPS) levels the limulus amebocyte assay microbiome 16S rDNA analysis. Results Compared to UHCs, FDRs exhibited elevated plasma but not similar total IgGs. median IgGs...