A5014765943- interferon and immune responses
- CAR-T cell therapy research
- Hippo pathway signaling and YAP/TAZ
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Immunotherapy and Immune Responses
- Viral Infections and Vectors
- Cancer-related gene regulation
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Research on Leishmaniasis Studies
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- CRISPR and Genetic Engineering
- Cancer, Lipids, and Metabolism
- Parasites and Host Interactions
- Erythrocyte Function and Pathophysiology
- Ion channel regulation and function
- HIV/AIDS drug development and treatment
- Cytomegalovirus and herpesvirus research
- Sulfur Compounds in Biology
- Genomics and Chromatin Dynamics
Shanghai Jiao Tong University
2020-2024
Shaoxing University
2024
Center for Disease Control
2024
Fudan University
2016-2021
Nanjing Medical University
2021
Huashan Hospital
2016-2020
Cell-intrinsic cGAS-STING–mediated DNA sensing promotes the formation of stem cell–like CD8 + T cells for effective cancer cell therapy.
Necroptosis, a form of regulated necrosis, participates in tumor development and dying cell immunogenicity. However, it remains unclear how cell–intrinsic necroptotic signaling contributes to radiation-induced antitumor immunity. Here, we found that the ZBP1-MLKL cascade irradiated cells was essential for ZBP1-dependent activation MLKL potentiated type I interferon responses following irradiation. Mechanistically, induced cytoplasmic DNA accumulation and, turn, autonomously activated...
Glioblastoma survival remains unchanged despite continuing therapeutic innovation. Herein, we aim to (i) develop chimeric antigen receptor (CAR) T cells with a specificity unique antigen, carbonic anhydrase IX (CAIX), which is expressed in the hypoxic microenvironment characteristic of glioblastoma, and (ii) demonstrate its efficacy limited off-target effects.First demonstrated expression CAIX patient-derived glioblastoma samples available databases. CAR were generated against was assessed 4...
Natural killer (NK) cells are cytotoxic innate lymphocytes that eradicate tumor cells. Inducing durable antitumor immune responses by NK represents a major priority of cancer immunotherapy. While cytosolic DNA sensing plays an essential role in initiating immunity, the cell-intrinsic STING signaling remains unclear. Here, we find promotes and maintains reservoir TCF-1+ In contrast, cGAS mtDNA required for cell activity, indicating recognition partially triggers activation. Moreover, addition...
Loss of a cell's ability to terminally differentiate because mutations is selected genetic event in tumorigenesis. Genomic analyses low-grade glioma have reported recurrent far upstream element-binding protein 1 (FUBP1). Here, we show that FUBP1 expression dynamically regulated during neurogenesis and its downregulation neural progenitors impairs terminal differentiation promotes tumorigenesis collaboratively with IDH1R132H. Mechanistically, collaborative action between SRRM4 necessary for...
Mitochondrial antiviral signaling protein (MAVS)-mediated cytosolic RNA sensing plays a central role in tumor immunogenicity. However, the effects of host MAVS on antitumor immunity remain unclear. Here, we demonstrate that pathway supports growth and impairs immunity, whereas deficiency dendritic cells (DCs) promotes tumor-reactive CD8+ T cell responses. Specifically, priming capacity was enhanced by ablation type I interferon-independent, but IL-12-dependent, manner. Mechanistically, loss...
The number and proportion of HIV/AIDS patients among older people are continuously rapidly increasing in China. We conducted a detailed molecular epidemiological analysis HIV-1 epidemic strains developed city eastern China found that elderly play crucial role the transmission subtypes high pretreatment drug resistance (PDR). A total 1048 samples were obtained from 1129 (92.8%) newly confirmed HIV-1-positive treatment-naive between 2019 2023. 1316 bp target fragment pol gene was amplified by...
Macrophages in the tumor microenvironment play a critical role tumorigenesis and anti-cancer drug resistance. Burkitt's lymphoma (BL) is B-cell non-Hodgkin's with dense macrophage infiltration. However, for macrophages BL remains largely unknown.B7-H1, transmembrane glycoprotein B7 family, suppresses T cell activation proliferation induces apoptosis of activated cells. The expression B7-H1 clinical tissues was determined by streptavidin-peroxidase immunohistochemistry. mutual regulation...
Changes in mechanosensitive ion channels following radiation have seldom been linked to therapeutic sensitivity or specific factors involved antitumor immunity. Here, this study, we found that the mechanical force sensor, Piezo2, was significantly upregulated tumor cells after radiation, and Piezo2 knockout enhanced growth suppression by radiotherapy. Specifically, loss of induced their IL-15 expression via unleashing JAK2/STAT1/IRF-1 axis radiation. This increase activates IL-15Rα on...
In the present study, we attempted to elucidate mechanisms for regulation of intracellular calcium levels by H 2 S in primary rat medullary neurons. Our results showed that NaHS significantly increased level neurons a concentration‐dependent manner. L‐Cysteine and SAM raised while HA and/or AOAA produced reversal effect. addition, L‐cysteine but decreased production cultured The elevation induced was diminished EGTA‐Ca 2+ ‐free solutions, this also reduced nifedipine or nimodipine...
To seek survival-related genes in glioblastoma and establish a survival-gene signature for predicting prognoses of using public databases. Methods: Three independent glioma databases (GEO GSE53733, CGGA, TCGA) with whole genome expression data were included analysis. Survival-related obtained by comparing the long-term (>36 months) short-term (<12 survivors database GSE53733. CGGA was used as training set to develop TCGA validation set. Cox regression analysis linear risk score assessment...
Abstract EGFR is frequently amplified, mutated, and overexpressed in malignant gliomas. Yet the EGFR-targeted therapies have thus far produced only marginal clinical responses, underlying mechanism remains poorly understood. Using an inducible oncogenic EGFR-driven glioma mouse model system, our current study reveals that a small population of cells can evade therapy-initiated apoptosis potentiate relapse development by adopting mesenchymal-like phenotypic state no longer depends on...
<title>Abstract</title> Background The number and proportion of HIV/AIDS patients among older people are continuously rapidly increasing in China. We conducted a detailed molecular epidemiological analysis HIV-1 epidemic strains developed city eastern China found that elderly play crucial role the transmission subtypes high pretreatment drug resistance (PDR). Methods A total 1048 samples were obtained from 1129 (92.8%) newly confirmed HIV-1-positive treatment-naive between 2019 2023. 1316 bp...
Loss of terminal differentiation capacity through genetic mutations is a selected event in tumorigenesis. 1p19q co-deletion associated recurrent far upstream element-binding protein 1 (FUBP1) have been reported from genomic analysis low- grade oligodendroglioma. It frequently overexpressed many human cancers and strongly correlated with disease progression. However, left unanswered how FUBP1 serves uniquely as tumor suppressor the central nervous system. Here we show that expression...
Abstract Loss of terminal differentiation capacity through genetic mutations is a selected event in tumorigenesis. 1p19q co-deletion associated recurrent far upstream element-binding protein 1 (FUBP1) have been reported from genomic analysis low- grade oligodendroglioma. It frequently overexpressed many human cancers and strongly correlated with disease progression. However, left unanswered how FUBP1 serves uniquely as tumor suppressor the central nervous system. Here we show that expression...
Epidermal growth factor receptor (EGFR) is frequently amplified, mutated and overexpressed in malignant gliomas. Our investigation of the proximal distal responses to EGFR inhibition identified molecular mechanisms for therapeutic resistance Oncogenic EGFRviii-dependent gliomas initially showed cytotoxic upon removal oncogenic cue. However, during initial regression, a subset tumor cells with activated mesenchymal subtype gene expression program emerged by lineage reprogramming which...
Abstract Epidermal growth factor receptor (EGFR) is frequently amplified, mutated and overexpressed in malignant gliomas. Yet the EGFR-targeted therapies have thus far produced only marginal clinical response, underlying mechanism remains poorly understood. Through analyses of an inducible oncogenic EGFR-driven glioma mouse model system, our current study reveals a small population cells that can evade therapy-initiated apoptosis potentiate relapse development by adopting mesenchymal-like...