A5038280418- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer Treatment and Pharmacology
- interferon and immune responses
- Cancer, Lipids, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Integrated Circuits and Semiconductor Failure Analysis
- Lung Cancer Treatments and Mutations
- Cancer Research and Treatments
- Viral Infections and Vectors
- Inflammatory Biomarkers in Disease Prognosis
- Effects of Radiation Exposure
- Peptidase Inhibition and Analysis
- Histone Deacetylase Inhibitors Research
- Viral Infections and Outbreaks Research
- Polyamine Metabolism and Applications
- Advanced Breast Cancer Therapies
- Redox biology and oxidative stress
Shandong Tumor Hospital
2021-2025
Shandong First Medical University
2021-2025
Nantong University
2023-2024
Affiliated Hospital of Nantong University
2023-2024
Shandong University
2022-2024
Academy of Medical Sciences
2023
Sanofi (United States)
2023
Peking University
2020-2022
Peking University Cancer Hospital
2020-2022
Shanghai Jiao Tong University
2020
Preclinical and early clinical studies have demonstrated that chimeric antigen receptor (CAR)-redirected T cells are highly promising in cancer therapy. We observed targeting HER2 a glioblastoma (GBM) cell line results the emergence of HER2-null tumor maintain expression nontargeted tumor-associated antigens. Combinational these antigens could therefore offset this escape mechanism. studied single-cell coexpression patterns HER2, IL-13Rα2, EphA2 primary GBM samples using multicolor flow...
Cell-intrinsic cGAS-STING–mediated DNA sensing promotes the formation of stem cell–like CD8 + T cells for effective cancer cell therapy.
Necroptosis, a form of regulated necrosis, participates in tumor development and dying cell immunogenicity. However, it remains unclear how cell–intrinsic necroptotic signaling contributes to radiation-induced antitumor immunity. Here, we found that the ZBP1-MLKL cascade irradiated cells was essential for ZBP1-dependent activation MLKL potentiated type I interferon responses following irradiation. Mechanistically, induced cytoplasmic DNA accumulation and, turn, autonomously activated...
Evidence had been provided that a disulfide-linked [125I]iodotyramine/poly(D-lysine) conjugate was reductively cleaved when bound nonspecifically to the surface of Chinese hamster ovary (CHO) cells and this cleavage abolished by membrane-impermeant sulfhydryl blockers. The same blockers were subsequently found inhibit cytotoxicity diphtheria toxin, heterodimer binds specific receptor must undergo chain separation exert its cytotoxicity. This suggested disulfides both macromolecules might be...
Abstract Background Increasing evidence suggests that immunotherapy, especially immune checkpoint inhibitors (ICIs), has the potential to facilitate long-term survival in various cancer besides prostate cancer. Emerging indicated pyroptosis, an immunogenic form of cell death, could trigger anti-tumor microenvironment and enhance effectiveness immunotherapy. Nevertheless, mechanism underlying regulation pyroptosis signaling remains unclear. Methods The differential expression human E3 ligases...
Immunotherapy, especially immune checkpoint inhibitors, has revolutionized clinical practice within the last decade. However, primary and secondary resistance to immunotherapy is common in patients with diverse types of cancer. It well-acknowledged that tumor cells can facilitate formation immunosuppressive microenvironments via metabolism reprogramming, lactic acid, metabolite glycolysis, a significant contributor. SLC16A3 (also named as MCT4) transporter mediating acid efflux. In this...
Currently, due to synergy enhancement of anti-tumor effects and potent stimulation abscopal effects, combination therapy with irradiation programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) immune checkpoint inhibition (immuno-radiotherapy, iRT) has revolutionized the therapeutic guidelines. It been demonstrated that tumor-draining lymph nodes (TDLN) are essential for effective antitumor immunity induced by radiotherapy, immunotherapy, or iRT. Given function TDLN in iRT...
ABSTRACT Background Neutrophils interact with tumor cells, potentially exacerbating cancer progression. Additionally, decreased albumin levels are a marker of poor prognosis. The neutrophil‐percentage‐to‐albumin ratio (NPAR) has been used for prognostic assessment in non‐cancerous diseases, but its relationship mortality risk patients not explored. Therefore, we utilized data from the National Health and Nutrition Examination Survey (NHANES) to investigate correlation between NPAR risks...
Background: Upregulation of H3K27me3 induced by EZH2 overexpression or somatic heterozygous mutations were implicated in lymphomagenesis. It has been demonstrated that several EZH2-target agents have notable therapeutic effects EZH2-mutant B-cell lymphoma patients. Here we present a novel highly selective inhibitor SHR2554 and possible combination strategy diffuse large (DLBCL). Methods: Cell proliferation, cell cycle apoptosis analyzed CellTiter-Glo Luminescent Viability Assay flow...
Background BANF1 is well known as a natural opponent of cyclic GMP-AMP synthase (cGAS) activity on genomic self-DNA. However, the roles in tumor immunity remain unclear. Here, we investigate possible impact antitumor and response to immunotherapy. Methods The Cancer Genome Atlas public data were analyzed evaluate relevance expression BANF1, patients’ survival immune cell infiltration. We monitored growth explored efficacy targeting tumor-intrinsic combination with anti-programmed death...
Abstract Background The unprecedented efficacy of chimeric antigen receptor T (CAR-T) cell immunotherapy CD19 + B-cell malignancies has opened a new and useful way for the treatment malignant tumors. Nonetheless, there are still formidable challenges in field CAR-T therapy, such as biodistribution cells vivo. Methods NALM-6, human acute lymphoblastic leukemia (B-ALL) line, was used target cells. were injected into mice model with or without Then we measured distribution mice. In addition, an...
Background Recently, immunotherapy (IO) has shown striking survival improvement in unresectable stage III non-small cell lung cancer (NSCLC). However, the role of chemo-radiotherapy (CRT) for outcomes should not be disregarded. This study aimed to compare treatment patterns and illustrate impact radiotherapy on cancer-specific (CSS) overall (OS) patients with unresected locally advanced NSCLC. Methods We retrospectively analyzed data NSCLC who did undergo surgery from National Cancer...
Abstract Background Lymphoma is the most common secondary cause of hemophagocytic lymphohistiocytosis (HLH) in adults. Lymphoma‐associated HLH (LA‐HLH) elderly population not rare, however, little has been reported regarding clinicopathological characteristics, prognostic factors, and outcomes LA‐HLH population. Methods We retrospectively analyzed a multicenter cohort patients with LA‐HLH. Clinicopathological features treatment information were collected. The impacts baseline characteristics...
IMPDH2 is the rate-limiting enzyme of de novo GTP synthesis pathway and has a key role in tumors; however, specific mechanism underlying activity diffuse large B cell lymphoma (DLBCL) still undetermined. This study aims to explore potential DLBCL, its possible involvement double-hit (DHL), i.e., cases with translocations involving MYC BCL2 and/or BCL6.Using single-cell sequencing bioinformatics analysis screen for IMPDH2. Exploring differential expression correlation prognosis through...
Abstract Background Studies have shown higher chemosensitivity to anthracyclines in BRCA1-associated breast cancer (BABC) when compared sporadic triple-negative cancers (TNBC), possibly due differences DNA repair function. We hypothesized that a subset of TNBC with acquired BRCA1 deficiency and defective function will benefit most from DNA-damaging agents, such as anthracyclines. Methods applied previously published gene expression signature differentiates BABC three datasets Baylor College...