A5053880200- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Meningioma and schwannoma management
- Fibroblast Growth Factor Research
- Neurofibromatosis and Schwannoma Cases
- Bone Tumor Diagnosis and Treatments
- DNA Repair Mechanisms
- Plant Stress Responses and Tolerance
- CRISPR and Genetic Engineering
- Vasculitis and related conditions
- Otitis Media and Relapsing Polychondritis
- Neonatal Respiratory Health Research
- PARP inhibition in cancer therapy
- Plant Molecular Biology Research
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- S100 Proteins and Annexins
- Research in Cotton Cultivation
- CAR-T cell therapy research
- Platelet Disorders and Treatments
- IgG4-Related and Inflammatory Diseases
- Kruppel-like factors research
- Nanowire Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- RNA Research and Splicing
Xiamen University
2025
Cotton Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
Beijing Tian Tan Hospital
2012-2024
Capital Medical University
2012-2024
Chengdu University of Traditional Chinese Medicine
2021-2024
Binzhou University
2017-2024
Binzhou Medical University
2017-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2023
Beijing Radiation Center
2021-2022
Threonylcarbamoyladenosine (t(6)A) is a modified nucleoside universally conserved in tRNAs all three kingdoms of life. The recently discovered genes for t(6)A synthesis, including tsaC and tsaD, are essential model prokaryotes but not yeast. These had been identified as antibacterial targets even before their functions were known. However, the molecular basis this prokaryotic-specific essentiality has remained mystery. Here, we show that strong positive determinant aminoacylation tRNA by...
The objective of this study was to analyze the clinical manifestation, course, evolution, image and treatments LGI1 limbic encephalitis (LE).Studies confirmed that LE with complex antibody voltage-gated potassium channels is LE. Since then, cases have been reported. In study, 10 typical were searched in PubMed. These one additional case, which we reported herein, retrospectively analyzed.All patients suffered from recent memory deterioration. following observed: eight faciobrachial dystonic...
Glioblastoma survival remains unchanged despite continuing therapeutic innovation. Herein, we aim to (i) develop chimeric antigen receptor (CAR) T cells with a specificity unique antigen, carbonic anhydrase IX (CAIX), which is expressed in the hypoxic microenvironment characteristic of glioblastoma, and (ii) demonstrate its efficacy limited off-target effects.First demonstrated expression CAIX patient-derived glioblastoma samples available databases. CAR were generated against was assessed 4...
Meningiomas are the most common adult primary tumor of central nervous system, but there no known effective medical therapies for recurrent meningioma, particularly World Health Organization grade II and III tumors. arise from meninges, located outside blood-brain barrier, therefore may be directly targeted by antibody-mediated immunotherapy. We found that programmed cell death ligand 1 (PD-L1) was highly expressed in multiple human malignant meningioma lines patient samples. PD-L1 with...
Liquid chromatography tandem mass spectrometry (LC-MS/MS) has proven to be a powerful analytical tool for the characterization of modified ribonucleic acids (RNAs). The typical approach analyzing nucleosides within RNA sequences by involves ribonuclease digestion followed LC-MS/MS analysis and data interpretation. Here we describe new software tool, RNAModMapper (RAMM), assist in interpretation data. RAMM is stand-alone package that requires user-submitted DNA or create local database...
Video data and algorithms have been driving advances in multi-object tracking (MOT). While existing MOT datasets focus on occlusion appearance similarity, complex motion patterns are widespread yet overlooked. To address this issue, we introduce a new dataset called BEE24 to highlight motions. Identity association long the of research. Existing trackers can be categorized into two paradigms: single-feature paradigm (based either or feature) serial (one feature serves as secondary while other...
There has been a renewed appreciation for the dynamic nature of ribonucleic acid (RNA) modifications and impact modified RNAs on organism health resulting in an increased emphasis developing analytical methods capable detecting within specific RNA sequence contexts. Here we demonstrate that DNA-based exclusion list enhances data dependent liquid chromatography tandem mass spectrometry (LC-MS/MS) detection post-transcriptionally nucleosides sequences. This approach is possible because all...
The relapsing polychondritis (RP) patients with central nervous system (CNS) involvement were rare. We aimed to determine the clinical characteristics of RP CNS involvement. data 181 patients, hospitalized at Peking Union Medical College Hospital between December 2005 and February 2019, collected. categorized into two subgroups: 25 involvement, 156 without ear was more frequent in compared those ( P < 0.01). After controlling sex admission age, logistic regression analysis revealed...
Triacylglycerol Lipases (TGLs) are the major enzymes involved in triacylglycerol catabolism. TGLs hydrolyze long-chain fatty acid triglycerides, which plant development and abiotic stress responses. Whereas most studies of have focused on seed oil metabolism biofuel plants, limited information is available regarding genome-wide identification characterization TGL gene family tomato (Solanum lycopersicum L.). Based latest published genome annotation ITAG4.0, 129 SlTGL genes were identified...
To investigate the clinical characteristics of Guillain-Barré syndrome (GBS) in patients with primary Sjögren's (SS). Records positive anti-SSA antibodies hospitalized Beijing Tiantan Hospital between December 2011 and May 2020 were retrieved. Patients who fulfilled criteria for diagnosis GBS SS included, their data analyzed. Among 785 anti-SSA, 52 identified this study. They 27 males 25 females median age 59 years old. Besides antibodies, multiple autoantibodies detected these including...
Standard therapy for chordoma consists of surgical resection followed by high-dose irradiation. Protein phosphatase 2A (PP2A) is a ubiquitously expressed serine/threonine involved in signal transduction, cell cycle progression, differentiation, and DNA repair. LB100 small-molecule inhibitor PP2A designed to sensitize cancer cells damage from irradiation chemotherapy. A recently completed phase I trial solid tumors demonstrated its safety. Here, we show the therapeutic potential...