A5101771855- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Animal Disease Management and Epidemiology
- Vector-borne infectious diseases
- Remote Sensing and Land Use
- Vector-Borne Animal Diseases
- Research on Leishmaniasis Studies
- Transboundary Water Resource Management
- Geology and Paleoclimatology Research
- Plant and animal studies
- Climate Change, Adaptation, Migration
- Environmental Quality and Pollution
- Parasites and Host Interactions
- Plant Physiology and Cultivation Studies
- Advanced Mathematical Physics Problems
- Health and Conflict Studies
- Climate variability and models
- Environmental Changes in China
- Climate Change and Health Impacts
- Regional Economic and Spatial Analysis
- Coastal wetland ecosystem dynamics
- Cardiovascular Health and Disease Prevention
- Malaria Research and Control
- China's Socioeconomic Reforms and Governance
- Insect and Pesticide Research
Mahidol Oxford Tropical Medicine Research Unit
2022-2025
Mahidol University
2022-2025
University of Oxford
1996-2024
Tsinghua University
2016-2024
Qingdao University
2023-2024
Affiliated Hospital of Qingdao University
2023-2024
Angkor Hospital for Children
2024
Second Affiliated Hospital of Nanjing Medical University
2024
Chinese Academy of Sciences
2006-2023
Nuffield Orthopaedic Centre
2023
A study was made of the role fibula in weightbearing and its contribution to ankle joint stability 10 anatomic specimen lower limbs. On axial loading limb, found take an average 17% a 1500 N load. The proportion load carried by increased with total loading. It also when line displaced laterally dorsiflexion decreased shifted medially or plantar flexed. With loading, lateral malleolus migrated distally relative medial malleolus, except after fibular osteotomy, it proximally. There...
Many enzymes catalyzing biological redox chemistry depend on the omnipresent cofactor, nicotinamide adenine dinucleotide (NAD). NAD is also involved in various nonredox processes. It remains challenging to disconnect one particular NAD-dependent reaction from all others. Here we present a bioorthogonal system that catalyzes oxidative decarboxylation of l-malate with dedicated abiotic flucytosine (NFCD). By screening multisite saturated mutagenesis libraries malic enzyme (ME), identified...
The superior colliculus (SC) in the mammalian mesencephalon is involved avoidance or escape behaviors, but little known about response properties of collicular neurons to an object approaching on a collision course towards animal. present study identified two classes looming-sensitive neurons, rho and eta cells, SC cat, did not find any tau cell, which has been observed pigeon tectofugal pathway. looming responses were characterized by distinct firing patterns, neuronal discharge steadily...
<title>Abstract</title> Scrub typhus, an acute febrile illness caused by <italic>Orientia tsutsugamushi</italic>, has emerged as a significant public health concern, expanding beyond its traditional endemic region, the "tsutsugamushi triangle" in Asia-Pacific. Despite increasingly global distribution, comprehensive spatial assessments of scrub typhus risk remain sparse. An exhaustive assembly 56,093 unique human occurrence records worldwide was undertaken from published literature and...
A set of related capillary zone electrophoresis (CZE) methods have been developed for the analysis identity, charge variants, and disulfide isoforms IgG monoclonal antibodies (mAbs). These utilize an uncoated column. The combined use concentrated zwitterionic (e-amino-caproic acid) buffer acid flushing was effective in minimizing adsorption protein to inner wall a bare capillary. Under these conditions, selective reproducible separation multiple IgG1 IgG2 (mAbs) obtained with long column (40...
Klainerman introduced in [7] the hyperboloidal method to prove global existence results for nonlinear Klein–Gordon equations by using commuting vector fields. In this paper, we extend from Minkowski space Lorentzian spacetimes. This approach is developed [15] proving, under maximal foliation gauge, stability of Einstein with massive scalar fields, which states that, sufficiently small data a compact domain, surrounded Schwarzschild metric, leads unique, globally hyperbolic, smooth and...
African swine fever (ASF) has spread to many countries in Africa, Europe and Asia the past decades. However, potential geographic extent of ASF infection is unknown. Here we combined a modeling framework with assembled contemporary records cases multiple covariates predict risk distribution at global scale. Local spatial variations derived from domestic pigs influenced strongly by livestock factors, while having wild boars mainly associated natural habitat covariates. The maps show that be...
Abstract Scrub typhus is a climate‐sensitive and life‐threatening vector‐borne disease that poses growing public health threat. Although the climate‐epidemic associations of many diseases have been studied for decades, impacts climate on scrub remain poorly understood, especially in context global warming. Here we incorporate Chinese national surveillance data from 2010 to 2019 into climate‐driven generalized additive mixed model explain spatiotemporal dynamics this predict how it may be...
The Zika virus (ZIKV) outbreak and its link to microcephaly triggered a public health concern. To examine antibody response in patient infected with ZIKV, we used single-cell PCR clone 31 heavy light chain-paired monoclonal antibodies (mAbs) that bind ZIKV envelope (E) proteins isolated from memory B cells of ZIKV-infected patient. Three mAbs (7B3, 1C11, 6A6) showed the most potent broad neutralization activities against African, Asian, American strains were selected for further analysis....
Visceral leishmaniasis (VL) is a neglected disease caused by trypanosomatid protozoa in the genus Leishmania, which transmitted phlebotomine sandflies. Although this vector-borne has been eliminated several regions of China during last century, reported human VL cases have rebounded Western and Central recent decades. However, understanding spatial epidemiology remains vague, as risk factors driving heterogeneity VL. In study, we analyzed spatiotemporal patterns annual from 2007 to 2017....
Artemisinin, which is isolated from the naturally occurring plant Artemisia annua L. (A. annua; Qinghao in traditional Chinese medicine), considered to be active ingredient most effective treatment for malaria. Current malaria eradication plans rely on an affordable and robust supply of artemisinin, resulting demand expand area A. under cultivation. However, there no reliable assessment potential land resources suitable planting at global scale. By explicitly incorporating assembled...
Abstract Global climate change, expected to be one of the most severe challenges that human beings have ever encountered, has had far-reaching impacts on ecosystems and humans, among which potentially increasing chance violent conflict raised attention recently. However, several years research produced no consensus regarding whether variability affects risk armed how it may affect conflict. In this study, we built a geographically disaggregated method explore relationship between from normal...
Abstract Background Visceral leishmaniasis (VL) is a neglected disease that spread to humans by the bites of infected female phlebotomine sand flies. Although this vector-borne has been eliminated in most parts China, it still poses significant public health burden Xinjiang Uygur Autonomous Region. Understanding spatial epidemiology remains vague local community. In present study, we investigated spatiotemporal distribution VL region order assess potential threat disease. Methods Based on...