A5078589170- Erythropoietin and Anemia Treatment
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Blood transfusion and management
- Hemoglobinopathies and Related Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Eosinophilic Disorders and Syndromes
- Glioma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- PARP inhibition in cancer therapy
- T-cell and B-cell Immunology
- Erythrocyte Function and Pathophysiology
- Acute Lymphoblastic Leukemia research
- Blood groups and transfusion
- Iron Metabolism and Disorders
- Pancreatic function and diabetes
- Platelet Disorders and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Immune cells in cancer
- Pharmacological Effects and Toxicity Studies
- Cardiac Ischemia and Reperfusion
- Quinazolinone synthesis and applications
Western University
2014-2024
London Health Sciences Centre
2015-2024
Leukemia & Lymphoma Society of Canada
2024
Foothills Medical Centre
2020
Bridge University
2017
Canadian Armed Forces
2010-2015
Princess Margaret Cancer Centre
2003-2014
Sunnybrook Health Science Centre
2004-2013
Hamilton Health Sciences
2013
Lawson Health Research Institute
2007-2012
Numerous studies have shown that the bone marrow (BM) niche plays a key role in mouse hematopoietic stem cell (HSC) function and involves contributions from broad array of types. However, composition human BM HSC not been investigated. Here, using biopsy specimens, we provide evidence propensity to localize endosteal regions trabecular area (TBA). Through functional xenograft transplantation, found HSCs localizing TBA superior regenerative self-renewal capacity are molecularly distinct those...
Erythropoietin (EPO), a cytokine best known for its ability to increase red blood cell mass, has recently been shown protect cardiomyocytes from apoptotic death. The objective of the present study was investigate role endothelial nitric oxide synthase (eNOS) in anti-apoptotic effects EPO cardiomyocytes.Neonatal mouse ventricular were isolated and cultured wild-type eNOS(-/-) mice. Treatment with significantly reduced apoptosis induced by norepinephrine (NE) cardiomyocytes. reduction...
Objective: Erythropoietin (EPO) prevents the myocardial dysfunction induced by ischemia/reperfusion (I/R). Since I/R-induced is associated with an acute inflammatory response, we assessed anti-inflammatory properties of EPO using in vitro and vivo models I/R.
To determine whether autologous (auto) or allogeneic (allo) stem-cell transplantation (SCT) improves outcome in patients with transformed follicular lymphoma compared rituximab-containing chemotherapy alone.This was a multicenter cohort study of and subsequent biopsy-proven aggressive histology transformation. Patient, treatment, data were collected from each center combined for analysis. A separate control group composed transformation treated but not SCT. The primary end point overall...
Allogeneic hematopoietic stem cell (HSC) transplantation (HSCT) is currently the leading strategy to manage acute myeloid leukemia (AML). However, treatment-related morbidity limits patient generalizability of HSCT use, and survival leukemic cells (LSCs) within protective areas bone marrow (BM) continues lead high relapse rates. Despite growing appreciation for significance LSC microenvironment, it has remained unresolved whether LSCs preferentially situate normal HSC niches or their niche...
Transplanted murine bone marrow (BM) progenitor cells recruit to the injured pancreas and induce endogenous beta cell proliferation improve islet function. To enrich for analogous human types that stimulate regeneration, we purified BM based on high-aldehyde dehydrogenase activity (ALDH(hi)), an enzymatic function conserved in hematopoietic, endothelial, mesenchymal lineages. We investigated contributions of ALDH(hi) mixed or culture-expanded, ALDH-purified multipotent stromal (MSC) subsets...
PURPOSE Evidence regarding red blood cell (RBC) transfusion practices and their impact on hematopoietic transplantation (HCT) outcomes are poorly understood. PATIENTS AND METHODS We performed a noninferiority randomized controlled trial in four different centers that evaluated patients with hematologic malignancies requiring HCT who were randomly assigned to either restrictive (hemoglobin [Hb] threshold < 70 g/L) or liberal (Hb 90 RBC strategy between day 0 100. The margin corresponds 12%...
Novel chitosan-carrageenan nanoparticles were produced through the process of ionotropic gelation for encapsulation and controlled release recombinant human erythropoietin (rHu-EPO). The effects chitosan concentration, to carrageenan mass ratio solution pH on nanoparticle diameter, polydispersity surface charge explored both screening response modeling (RSM) methods. created had particle diameters between 200 1000nm, surfaces charges 40 55mV, 0.2 0.35. RSM optimized demonstrated an increased...
Summary Multiple studies have reported a significant treatment‐free remission (TFR) rate of 50%–60% in patients with chronic myeloid leukaemia (CML) who discontinue tyrosine kinase inhibitor (TKI) therapy. However, the remaining half these still require re‐initiation TKI therapy for control. It remains unclear if drugs should be switched re‐therapy failed first TFR (TFR1) attempt. Our study attempted to determine whether dasatinib after TFR1 failure post‐imatinib discontinuation could...
The relationship between oxygen delivery and consumption in sepsis is impaired, suggesting a microcirculatory perfusion defect. Recombinant human erythropoietin (rHuEPO) regulates erythropoiesis also exerts complex actions promoting the maintenance of homeostasis organism under stress. objective this study was to test hypothesis that rHuEPO could improve skeletal muscle capillary tissue oxygenation sepsis. Septic mice three experiments received rHu-EPO 400 U/kg subcutaneously 18 hours after...
Abstract The aim of this study was to investigate the role endothelial nitric oxide synthase (eNOS) in host myocardium on bone marrow mesenchymal stromal cells (MSC) migration ischemic and whether cell-derived factor-1α (SDF-1α) contributes eNOS-mediated MSC migration. MSCs coronary microvascular were isolated from adult wild-type (WT) mouse hearts, respectively. Cultured neonatal cardiomyocytes WT, eNOS−/−, eNOS overexpressing transgenic (Tg) mice subjected anoxia reoxygenation (A/R),...
Transplanted human bone marrow (BM) and umbilical cord blood (UCB) progenitor cells activate islet-regenerative or revascularization programs depending on the subtypes administered. Using purification of multiple based a conserved stem cell function, high aldehyde dehydrogenase (ALDH) activity (ALDHhi), we have recently shown that transplantation BM-derived ALDHhi progenitors improved systemic hyperglycemia augmented insulin secretion by increasing islet-associated proliferation...