A5089219710- Seaweed-derived Bioactive Compounds
- Protein Hydrolysis and Bioactive Peptides
- Echinoderm biology and ecology
- Skin Protection and Aging
- Insect Utilization and Effects
- Microbial Metabolites in Food Biotechnology
- Biochemical effects in animals
- Aquaculture Nutrition and Growth
- Natural product bioactivities and synthesis
- Muscle Physiology and Disorders
- Polysaccharides and Plant Cell Walls
- Fatty Acid Research and Health
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Spaceflight effects on biology
- Marine Sponges and Natural Products
- Muscle metabolism and nutrition
- Food Quality and Safety Studies
- melanin and skin pigmentation
- Macrophage Migration Inhibitory Factor
- Fluoride Effects and Removal
- Chromatography in Natural Products
- Ocular Surface and Contact Lens
- Apelin-related biomedical research
- Food Allergy and Anaphylaxis Research
Jeju National University
2018-2025
Sargassum horneri is edible brown seaweed abundant along the coasts of Jeju Island, South Korea. In addition to native S. population, a large amount has been found invade Island from east coast China. Thus, both Korea (SK) and China (SC) strains now inhabits with shore have become threat coastal biodiversity. However, they could be used in obtaining functional ingredients for industrial level applications provided an optimized cost effective strategy. present study, we compared SK SC...
This study presents a comprehensive analysis of gymnodimine-series toxins produced by Alexandrium ostenfeldii (K- 1354) using liquid chromatography tandem mass spectrometry (LC-MS/MS). Three peaks with identical precursor ions but different retention times were observed, suggesting the presence isomers identified as gymnodimines B, C, and D. Employing an integrated approach combining LC-MS/MS electron transfer dissociation, revealed characteristic fragment gymnodimine Notably, this...
The present study evaluated the effects of (–)-loliolide isolated from Sargassum horneri (S. horneri) against oxidative stress and inflammation, its biological mechanism in interferon (IFN)-γ/tumor necrosis factor (TNF)-α-stimulated HaCaT keratinocytes. results showed that improved cell viability by reducing production intracellular reactive oxygen species (ROS) IFN-γ/TNF-α-stimulated In addition, effectively decreased expression inflammatory cytokines (interleukin (IL)-4 IL-6, IL-13, IFN-γ...
Among the components derived from brown algae, anionic sulfated polysaccharides, which contain fucose as major monosaccharide, exert significant biological activities. In this study, we purified and structurally characterized polysaccharides Sargassum binderi (S. binderi; SBPs), evaluated their activity in vitro vivo. The SBPs were separated based on charges biophysical properties investigated according to functional groups, structural features, molecular weights using FTIR, NMR, MALS. all...
In this study, the anti-inflammatory activity of sulfated polysaccharides isolated from green seaweed Codium fragile (CFCE-PS) was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and zebrafish. The results demonstrated that CFCE-PS significantly increased viability LPS-induced cells a concentration-dependent manner. remarkably concentration-dependently reduced levels inflammatory molecules including prostaglandin E2, nitric oxide (NO), interleukin-1 beta, tumor...
There is a growing interest in the health benefits of functional foods. A benefit that has been long sought control hypertension through dietary approaches. Hypertension implicated as risk factor for cardiovascular disease and therefore clinical significance. Here, we aim to demonstrate antihypertensive activity novel peptides derived from surimi, food ingredient made refined fish myofibrillar proteins. Three peptides, Ile-Val-Asp-Arg (IVDR), Trp-Tyr-Lys (WYK), Val-Ala-Ser-Val-Ile (VASVI),...
Inflammation affects various organs of the human body, including skeletal muscle. Phlorotannins are natural biologically active substances found in marine brown algae and exhibit anti-inflammatory activities. In this study, we focused on effects phlorotannins activity muscle cell proliferation to identify protective inflammatory myopathy. First, five species algal extracts dramatically inhibited nitric oxide (NO) production lipopolysaccharide (LPS)-induced RAW 264.7 cells without toxicity at...
Ultraviolet (UV) irradiation is considered to be the primary environmental factor that causes skin damage. In present study, we investigated protective effect of dieckol (DK), a compound isolated from brown seaweed Ecklonia cava, against UVB-induced damage in human dermal fibroblasts (HDF cells). The results indicated DK effectively inhibited activity collagenase. remarkably reduced intracellular reactive oxygen species level and improved viability UVB-irradiated HDF cells. Besides,...
A global health concern has emerged as a response to the recent SARS-CoV-2 pandemic. The identification and inhibition of drug targets is decisive obligation scientists. In addition cell entry mechanism, expresses complicated replication mechanism that provides excellent targets. Papain-like protease (PLpro) 3-chymotrypsin-like (3CLpro) play vital role in polyprotein processing, producing functional non-structural proteins essential for viral survival host cell. Moreover, PLpro employed by...
Grateloupia elliptica (G. elliptica) is a red seaweed with antioxidant, antidiabetic, anticancer, anti-inflammatory, and anticoagulant activities. However, the anti-obesity activity of G. has not been fully investigated. Therefore, effect ethanol extract on suppression intracellular lipid accumulation in 3T3-L1 cells by Oil Red O staining (ORO) was evaluated. Among eight seaweeds tested, 60% (GEE) exhibited highest inhibition accumulation. GEE only to successfully suppress among extracts...
Loss of myofibers during muscle atrophy affects functional capacity and quality life. Dexamethasone, an inducer rapid skeletal myofibers, has been studied as a glucocorticoid receptor in or motor neurodegeneration. In this study, we examined dexamethasone-induced using zebrafish (Danio rerio), vertebrate model, assessed whether administration Lepidium meyenii (maca) dietary supplement can prevent atrophy. Changes were evaluated after exposure to dexamethasone for different periods at...
Particulate matters (PM), the main contributor to air pollution, have become a serious issue that threatens human’s health. Skin is largest organ in humans, as well primary exposed PM. Overexposure of PM induces skin damage. Diphlorethohydroxycarmalol (DPHC), an algal polyphenol with potential protection, has been isolated from edible brown seaweed Ishige okamurae. The purpose present study investigate protective effect DPHC against (ERM-CZ100)-induced damage human dermal fibroblasts (HDF)...
Background: A sea cucumber (Stichopus japonicus) is an invertebrate rich in high-quality protein peptides that inhabits the coastal seas around East Asian countries. Such bioactive can be utilized targeted disease therapies and practical applications nutraceutical industry. Methods: Bioactive were isolated from Stichopus japonicus through ultrafiltration Sephadex G-10 size exclusion chromatography. The low-molecular-weight fraction (ACSH-III) showed highest hydroxyl radical scavenging...